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Description
Bug Report
Use Asp.NET web appliction without setting LoaderOptimization.SingleDomain results in site error 500 with "Loading this assembly would produce a different grant set from other instances"
Symptom
Describe the bug
Most IIS web-applications for .Net Framework using Otel.AutoInstrumentation are non-functional without applying
LoaderOptimization.SingleDomain through registry settings.
Expected behavior
Web applications should continue to work without registry modifications
Additional context
Origanally reported in #3839, workaround (with registry change) suggested in #3996.
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