The full distribution allows you to use Handsontable by just including 2 files:
<script src="dist/handsontable.full.js"></script>
<link rel="stylesheet" media="screen" href="dist/handsontable.full.css">
(It may also require jQuery, if you're using the Datepicker for date input)
handsontable.full.js and handsontable.full.css are compiled with all the needed dependencies.
Using this has the same effect as loading all the dependencies from the Bare distribution (see below).
If you are a "Bob the Builder" kind of hacker, you will need to load Handsontable JS, CSS and their dependecies:
<script src="dist/handsontable.js"></script>
<script src="lib/numeral.js"></script>
<link rel="stylesheet" media="screen" href="dist/handsontable.css">
handsontable.js and handsontable.css are compiled without the needed dependencies.