Some more context when this is relevant.

flowchart LR
    httpx-->|slow network| server
      subgraph one[Host 1]
        client-->|localhost\nconnection| quart
        subgraph quart[Quart app]
          httpx[httpx async\nclient]
        end
      end
      subgraph two[Host 2]
        server
      end

In this configuration, the Quart app acts as a proxy. As the httpx client is slowly consuming data because of the network speed, Quart buffers incoming data which is being uploaded at a very high speed because of a localhost connection. For huge payloads, this results in either memory allocation errors, or the out-of-memory killer killing the app.

^ From @andrewsh