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A Circuit Analysis of the Drosophila Brain using Connectivity Based Classification

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This repository contains code, data, and relevant information to replicate the analysis and results described in Circuit Analysis of the Drosophila Brain using Connectivity-based Neuronal Classification Reveals Organization of Key Communication Pathways, by Ketan Mehta, Rebecca F. Goldin, and Giorgio A. Ascoli.

Contents

data

  • Flycircuit neuron list along with other metadata and descriptors
  • Strength connectome from FlyCircuit data

generate_connectomes

  • Generate stochastic binary connectomes using FlyCircuit Data
  • Automatic picking of the dimenisonalty of embedding parameter using the scree plot

clustering

  • MBHAC Clustering
  • IVC Consensus Clustering
  • Creating the final connectivity-based classes
  • Obtaining the edge probabilities by paramterizing as a SBM

stat_analysis

  • NMI: normalized mutual information to compare different classification schemes
  • ARI: adjusted Rand index

labels

  • Classification labels
  • Graph-theoretic labels

random_walk : Performing random walk on the connectivity-based circuit absorbtion-driftiness

spad : Spatial distribution of the neurons using FlyCricuit and natverse atlas

morph_pvec : Morphology and persistence vector classification

supporting_information : Supplementary figures, tables, files and movie-clips.

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A Circuit Analysis of the Drosophila Brain using Connectivity Based Classification

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