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@bigbio

BigBio Stack

Provide big data solutions Bioinformatics

Welcome to bigbio 👋

bigbio is an open-source organization dedicated to advancing bioinformatics and computational proteomics and multiomics research. We develop scalable tools, workflows, and libraries to support complex experimental designs in proteomics, genomics and multiomics. Our mission is to empower researchers with accessible, efficient, and cutting-edge solutions for data analysis and integration.

🌟 Key Projects

🔬 Proteomics and Quantitative Analysis

  • quantms: A comprehensive workflow for proteomics experiments supporting DDA-LFQ, DDA-Isobaric, and DIA-LFQ quantification.
  • quantms.io: A proteomics quantification format extending mzTab for large-scale datasets.
  • ibaqpy: A package for absolute quantification based on the quantms.io format.
  • quantms.org: Code for quantms.org, a resource for reanalysis and public proteomics data.

🧪 Multiomics and Metadata Tools

⚡ Workflow Utilities

  • pmultiqc: A QC report library based on the MultiQC framework.
  • spectrafuse: An incremental clustering pipeline for quantms data.
  • quantms-utils: Helper scripts and classes for the quantms workflow.
  • quantms-rescoring: Helper functions and scripts for quantms and ms2rescore.

🤝 Contributions

We welcome contributions from the community! Whether it's bug fixes, feature suggestions, or documentation improvements, every contribution helps drive bioinformatics research forward.

🔗 Stay Connected

Join us on this journey to revolutionize data analysis in proteomics and beyond!

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  1. proteomics-sample-metadata Public

    The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    84 108

  2. quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 42 42

Repositories

Showing 10 of 48 repositories
  • quantms-containers Public

    DIANN docker container based on the linux version from DIANN

    Dockerfile 1 Apache-2.0 2 0 0 Updated Apr 12, 2025
  • proteomics-sample-metadata Public

    The Proteomics sample metadata: Standard for experimental design annotation in proteomics datasets

    84 GPL-2.0 108 63 (41 issues need help) 4 Updated Apr 10, 2025
  • pmultiqc Public

    A library for QC report based on MultiQC framework

    Python 14 GPL-3.0 9 7 (1 issue needs help) 2 Updated Apr 10, 2025
  • quantms Public

    Quantitative mass spectrometry workflow. Currently supports proteomics experiments with complex experimental designs for DDA-LFQ, DDA-Isobaric and DIA-LFQ quantification.

    Nextflow 42 MIT 42 56 (4 issues need help) 1 Updated Apr 4, 2025
  • sdrf-pipelines Public

    A repository to convert SDRF proteomics files into pipelines config files

    Python 19 Apache-2.0 25 30 (5 issues need help) 2 Updated Apr 3, 2025
  • quantms.io Public

    The proteomics quantification format, extending mzTab for large scale datasets.

    Python 9 4 20 (1 issue needs help) 0 Updated Apr 1, 2025
  • hvantk Public

    Hail variant annotation toolkit

    Python 0 MIT 0 2 0 Updated Mar 31, 2025
  • quantms-rescoring Public

    quantms and ms2rescore helper functions and scripts

    Python 0 Apache-2.0 1 0 1 Updated Mar 28, 2025
  • quantms-ptms Public

    quantms-ptms

    Python 0 MIT 0 0 0 Updated Mar 26, 2025
  • Nextflow 0 MIT 0 0 0 Updated Mar 15, 2025

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