Adding initial blood glucose level as an input to the simulator

[celikalp]

How can I add initial fasting blood glucose as an input parameter to the simulator?

[celikalp]

Gb is the initial fasting bg. I re-computed values of Gs, Gpb, Gtb, EGPb, Vm0 and it did the job. I used the paper to interpret the equations. Here is the code:

@classmethod
def withName(cls, name, **kwargs):
    '''
    Construct patient by name.
    Names can be
        adolescent#001 - adolescent#010
        adult#001 - adult#001
        child#001 - child#010
    '''
    patient_params = pd.read_csv(PATIENT_PARA_FILE)
    params = patient_params.loc[patient_params.Name == name].squeeze()
    # set fasting blood glucose if given in kwargs
    if 'fasting_bg' in kwargs and kwargs['fasting_bg'] is not None:
        params.Gb = kwargs['fasting_bg']
        params.Gpb = params.Gb * params.Vg
        params.EGPb = params.kp1 - params.kp2 * params.Gpb - params.kp3 * params.Ib
        Gtb = (params.Fsnc - params.EGPb + params.k1 * params.Gpb) / params.k2
        params.Vm0 = (params.EGPb - params.Fsnc) * (params.Km0 + Gtb) / Gtb
        params.iloc[5] = params.Gpb
        params.iloc[6] = Gtb
        params.iloc[14] = params.Gpb
    kwargs.pop('fasting_bg', None)
    return cls(params, **kwargs)

[celikalp]

I think, @jxx123 you may want to fix #18.

[jxx123]

@aacelik Thanks! I will take a look. If you want to go head and fix it, please send me a pull request :)

[junzhuang-code]

Hi @aacelik and @jxx123,

I'm interested in following up on this question. After this new feature added, is it possible for the user to select a new initial blood glucose level for the patient?

For example,
Patient adolescent#002 has an initial glucose level 152.41. I want to change this level to another number (let's say 120) at the beginning.
I read the repo and the article that you used to implement this repo. I attempted to change some parameters in "vpatient_params.csv" as follows: 1. Changed Vg and u2ss; 2. Changed from x0_1 to x0_13 and u2ss.
However, both attempts fail to fulfill this goal as the new BG keeps on increasing without any meal or insulin input.
I'm wondering whether or not I can change the initial glucose level of Patient adolescent#002 from 152.41 to 120 by using this new feature (or other features)?
If not, any parameters in "vpatient_params.csv" that I can change to achieve the same goal?
Please correct me if my understanding is imprecise.

Thanks for your reply in advance,

---

I think I've solved this issue. Forget my question.
Thanks,

[edger-asiimwe]

Hi @aacelik and @jxx123,

I'm interested in following up on this question. After this new feature added, is it possible for the user to select a new initial blood glucose level for the patient?

For example, Patient adolescent#002 has an initial glucose level 152.41. I want to change this level to another number (let's say 120) at the beginning. I read the repo and the article that you used to implement this repo. I attempted to change some parameters in "vpatient_params.csv" as follows: 1. Changed Vg and u2ss; 2. Changed from x0_1 to x0_13 and u2ss. However, both attempts fail to fulfill this goal as the new BG keeps on increasing without any meal or insulin input. I'm wondering whether or not I can change the initial glucose level of Patient adolescent#002 from 152.41 to 120 by using this new feature (or other features)? If not, any parameters in "vpatient_params.csv" that I can change to achieve the same goal? Please correct me if my understanding is imprecise.

Thanks for your reply in advance,

I think I've solved this issue. Forget my question. Thanks,

@junzhuang-code where you able to achieve this. Wanted to work with a similar situation where I set my initial BG, lets say at 7am.