Study of Zika virus evolution under Wolbachia selective pressure
- Mosquitoes fed on blood or ZIKV-infected mice
- Some mosquitoes were infected with Wmel (Wolbachia sp.); others were given Tetracycline ("Tet")
- We see reduced ZIKV dissemination (movement from midgut to legs to saliva) in the Wmel group
- We are interested in how the ZIKV population evolves during Wolbachia co-infection
- Calculate barcode frequencies
- Compare Tet to Wmel over time
- Nucleotide diversity
- Barcode frequency