How to simulate with inter-occasion variability?

[AndreasCalvagone]

This is something that was always possible in campsis (https://calvagone.github.io/campsis.doc/articles/v07_iov.html) and in the custom dataset window in e-Campsis.

For the exmaple below you need a an omega parameter specifying the IOV (here we call it OMEGA_IOVCL) and of course, a place in your model where the random IOV is added to:

Than you just need to add one line to the dataset specifying the IOV distribution, with mean=0 and the variability taken from the parameter value.

dataset <- Dataset(subjects=10) %>%
	add(Bolus(time=0, amount=1000, compartment=1, ii=24, addl=4)) %>%
	add(Observations(seq(0,96,by=6))) %>%
        add(IOV(colname="IOVCL", EtaDistribution(model, "IOVCL"))) %>%
	add(DatasetConfig(exportTSLD=TRUE, exportTDOS=TRUE))