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29159606.txt
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PMID - 29159606
OWN - NLM
STAT - Publisher
LR - 20171121
IS - 1432-2323 (Electronic)
IS - 0364-2313 (Linking)
DP - 2017 Nov 20
TI - Preoperative (68)Ga-DOTA-Somatostatin Analog-PET/CT Hybrid Imaging Increases
Detection Rate of Intra-abdominal Small Intestinal Neuroendocrine Tumor Lesions.
LID - 10.1007/s00268-017-4364-1 [doi]
AB - BACKGROUND: Small intestinal neuroendocrine tumors (SI-NETs) are the most common
form of neoplasm in the small bowel. Radiological identification of primary
"tumors (PT), which may be multiple, is difficult, and therefore palpation of the"
entire small bowel is routinely performed during laparotomy. The aim was to
determine detection rates of PT and peritoneal carcinomatosis (PC) with
(68)Ga-DOTATOC/TATE-PET/CT in comparison with i.v. contrast-enhanced computed
tomography (CE-CT) and thus to clarify whether modern functional imaging can
mitigate the need for palpation of bowel during surgery enabling oncologically
adequate laparoscopic resection. METHODS: A total of 28 patients with SI-NET who
preoperatively underwent both (68)Ga-DOTATOC/TATE-PET/CT and CE-CT were included.
The detection rates of PT and PC for PET/CT and CE-CT were compared to the
findings in the surgical and histopathological reports. Appropriate statistical
"tests were used, and significance was set to p < 0.05. RESULTS: Out of 82 PT, 43"
PT were not detected by any imaging modality. More PT lesions were detected with
"PET/CT (n = 39 [47.5%]) than with CE-CT (n = 10 [12.2%], p < 0.001). Also, PET/CT"
"identified significantly more PC lesions than CE-CT (78 and 38%, p = 0.004,"
respectively). CONCLUSION: PET/CT detected more PT and PC lesions than CE-CT.
"Some PTs and PC lesions were only detected by one of the modalities, and CT"
performed in conjunction with PET/CT should therefore be performed as a fully
diagnostic CE-CT for optimal results. Palpation of the small bowel remains
crucial during surgery in these patients because several PTs escaped detection by
both PET/CT and CE-CT.
FAU - "Norlen, Olov"
AU - Norlen O
AD - "Department of Surgery, Institute of Surgical Sciences, Uppsala University"
"Hospital, Uppsala University, Uppsala, Sweden."
FAU - "Montan, Harald"
AU - Montan H
AD - "Department of Radiology and Molecular Imaging, Institute of Surgical Sciences,"
"Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden."
FAU - "Hellman, Per"
AU - Hellman P
AD - "Department of Surgery, Institute of Surgical Sciences, Uppsala University"
"Hospital, Uppsala University, Uppsala, Sweden."
FAU - "Stalberg, Peter"
AU - Stalberg P
AD - "Department of Surgery, Institute of Surgical Sciences, Uppsala University"
"Hospital, Uppsala University, Uppsala, Sweden."
FAU - "Sundin, Anders"
AU - Sundin A
AUID - ORCID: http://orcid.org/0000-0002-2214-6217
AD - "Department of Radiology and Molecular Imaging, Institute of Surgical Sciences,"
"Uppsala University Hospital, Uppsala University, 751 85, Uppsala, Sweden."
anders.sundin@radiol.uu.se.
LA - eng
PT - Journal Article
DEP - 20171120
PL - United States
TA - World J Surg
JT - World journal of surgery
JID - 7704052
EDAT - 11/22/2017 6:00
MHDA - 11/22/2017 6:00
CRDT - 11/22/2017 6:00
PHST - 2017/11/22 06:00 [entrez]
PHST - 2017/11/22 06:00 [pubmed]
PHST - 2017/11/22 06:00 [medline]
AID - 10.1007/s00268-017-4364-1 [doi]
AID - 10.1007/s00268-017-4364-1 [pii]
PST - aheadofprint
SO - World J Surg. 2017 Nov 20. pii: 10.1007/s00268-017-4364-1. doi:
10.1007/s00268-017-4364-1.