Modeling of published clinical Verapamil-Midazolam-DDI studies for model evaluation.
Within this repository, we share a PK-Sim project file containing simulations of all published clinical studies used to evaluate the predictive performance of our models regarding the Verapamil-Midazolam-DDI, including the respective observed data. For further details and documentation please refer to [1].
PK-Sim Version 8.0.
The model is distributed under the GPLv2 License.
[1] Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T. A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies. Pharmaceutics 2020, 12(6), 556; https://doi.org/10.3390/pharmaceutics12060556