/
dto_vocabulary_gpcr_gene.owl
9600 lines (7770 loc) · 482 KB
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dto_vocabulary_gpcr_gene.owl
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<?xml version="1.0"?>
<!DOCTYPE rdf:RDF [
<!ENTITY DTO "http://dto.org/DTO/" >
<!ENTITY foaf "http://xmlns.com/foaf/0.1/" >
<!ENTITY life "http://www.lifekb.org/life#" >
<!ENTITY owl "http://www.w3.org/2002/07/owl#" >
<!ENTITY obo "http://purl.obolibrary.org/obo/" >
<!ENTITY xsd "http://www.w3.org/2001/XMLSchema#" >
<!ENTITY bto "http://purl.obolibrary.org/obo/bto#" >
<!ENTITY rdfs "http://www.w3.org/2000/01/rdf-schema#" >
<!ENTITY dto "http://www.drugtargetontology.org/dto/" >
<!ENTITY rdf "http://www.w3.org/1999/02/22-rdf-syntax-ns#" >
<!ENTITY core "http://purl.obolibrary.org/obo/uberon/core#" >
<!ENTITY dc "http://purl.org/dc/elements/1.1/" >
<!ENTITY oboInOwl "http://www.geneontology.org/formats/oboInOwl#">]>
<rdf:RDF xmlns="http://www.drugtargetontology.org/dto/dto_vocabulary_gpcr_gene.owl#"
xml:base="http://www.drugtargetontology.org/dto/dto_vocabulary_gpcr_gene.owl"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:life="http://www.lifekb.org/life#"
xmlns:core="&obo;uberon/core#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bto="&obo;bto#"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:dto="http://www.drugtargetontology.org/dto/"
xmlns:DTO="http://dto.org/DTO/"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<owl:Ontology rdf:about="http://www.drugtargetontology.org/dto/dto_vocabulary_gpcr_gene.owl">
<owl:versionIRI rdf:resource="http://www.drugtargetontology.org/dto/dto_vocabulary_gpcr_gene.owl"/>
<rdfs:label>Drug Target Ontology</rdfs:label>
<rdfs:label>DTO</rdfs:label>
<owl:versionInfo>1.0</owl:versionInfo>
<dc:date>2 Nov 2017</dc:date>
<dc:contributor>Yu Lin, Saurabh Mehta, Hande Küçük- McGinty, John Paul Turner, Dusica Vidovic, Michele Forlin, Amar Koleti, Dac-Trung Nguyen, Lars Juhl Jensen, Rajarshi Guha, Stephen L. Mathias, Oleg Ursu, Vasileios Stathias, Jianbin Duan, Nooshin Nabizadeh, Caty Chung, Christopher Mader, Ubbo Visser, Jeremy J. Yang, Cristian G. Bologa, Tudor Oprea*, Stephan C. Schürer*</dc:contributor>
<rdfs:comment xml:lang="en">contact: Stephan Schurer: stephan dot schurer at gmail dot com</rdfs:comment>
<dc:description>
Drug target ontology files Drug Target Ontology (DTO) is being developed at the University of Miami in the research group of Stephan Schürer.
DTO is supported by grant U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) awarded by the NCI through
the NIH Common Fund. It is a component of the Illuminating the Druggable Genome (IDG) project (https://commonfund.nih.gov/idg). The DTO project
develops a novel semantic framework to formalize knowledge about drug targets with a focus on the current IDG protein families. The DTO is developed
as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery
information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families,
GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO
also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue
relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a
modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov).
</dc:description>
<dc:license rdf:resource="https://creativecommons.org/licenses/by-sa/4.0/"/>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://www.drugtargetontology.org/dto/entrez_xref -->
<owl:AnnotationProperty rdf:about="http://www.drugtargetontology.org/dto/entrez_xref"/>
<!-- http://www.drugtargetontology.org/dto/geneSymbol -->
<owl:AnnotationProperty rdf:about="http://www.drugtargetontology.org/dto/geneSymbol"/>
<!-- http://www.drugtargetontology.org/dto/geneSynonym -->
<owl:AnnotationProperty rdf:about="http://www.drugtargetontology.org/dto/geneSynonym"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://www.drugtargetontology.org/dto/DTO_02200001 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200001">
<rdfs:label rdf:datatype="&xsd;string">HTR1A gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402001"/>
<dto:entrez_xref>3350</dto:entrez_xref>
<dto:geneSymbol>HTR1A</dto:geneSymbol>
<dto:geneSynonym>ADRB2RL1</dto:geneSynonym>
<dto:geneSynonym>ADRBRL1</dto:geneSynonym>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08908] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200002 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200002">
<rdfs:label rdf:datatype="&xsd;string">HTR1B gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402001"/>
<dto:entrez_xref>3351</dto:entrez_xref>
<dto:geneSymbol>HTR1B</dto:geneSymbol>
<dto:geneSynonym>HTR1DB</dto:geneSynonym>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200003 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200003">
<rdfs:label rdf:datatype="&xsd;string">HTR1D gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402001"/>
<dto:entrez_xref>3352</dto:entrez_xref>
<dto:geneSymbol>HTR1D</dto:geneSymbol>
<dto:geneSynonym>HTR1DA</dto:geneSynonym>
<dto:geneSynonym>HTRL</dto:geneSynonym>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 1D that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28221] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200004 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200004">
<rdfs:label rdf:datatype="&xsd;string">HTR1E gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402001"/>
<dto:entrez_xref>3354</dto:entrez_xref>
<dto:geneSymbol>HTR1E</dto:geneSymbol>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 1E that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28566] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200005 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200005">
<rdfs:label rdf:datatype="&xsd;string">HTR1F gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402001"/>
<dto:entrez_xref>3355</dto:entrez_xref>
<dto:geneSymbol>HTR1F</dto:geneSymbol>
<dto:geneSynonym>HTR1EL</dto:geneSynonym>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 1F that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30939] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200006 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200006">
<rdfs:label rdf:datatype="&xsd;string">HTR2A gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402002"/>
<dto:entrez_xref>3356</dto:entrez_xref>
<dto:geneSymbol>HTR2A</dto:geneSymbol>
<dto:geneSynonym>HTR2</dto:geneSynonym>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 2A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28223] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200007 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200007">
<rdfs:label rdf:datatype="&xsd;string">HTR2B gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402002"/>
<dto:entrez_xref>3357</dto:entrez_xref>
<dto:geneSymbol>HTR2B</dto:geneSymbol>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 2B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41595] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200008 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200008">
<rdfs:label rdf:datatype="&xsd;string">HTR2C gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402002"/>
<dto:entrez_xref>3358</dto:entrez_xref>
<dto:geneSymbol>HTR2C</dto:geneSymbol>
<dto:geneSynonym>HTR1C</dto:geneSynonym>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 2C that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28335] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200009 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200009">
<rdfs:label rdf:datatype="&xsd;string">HTR4 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402003"/>
<dto:entrez_xref>3360</dto:entrez_xref>
<dto:geneSymbol>HTR4</dto:geneSymbol>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q13639] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200010 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200010">
<rdfs:label rdf:datatype="&xsd;string">HTR5A gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402004"/>
<dto:entrez_xref>3361</dto:entrez_xref>
<dto:geneSymbol>HTR5A</dto:geneSymbol>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 5A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P47898] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200011 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200011">
<rdfs:label rdf:datatype="&xsd;string">HTR6 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402005"/>
<dto:entrez_xref>3362</dto:entrez_xref>
<dto:geneSymbol>HTR6</dto:geneSymbol>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50406] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200012 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200012">
<rdfs:label rdf:datatype="&xsd;string">HTR7 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402006"/>
<dto:entrez_xref>3363</dto:entrez_xref>
<dto:geneSymbol>HTR7</dto:geneSymbol>
<obo:IAO_0000115>A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200013 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200013">
<rdfs:label rdf:datatype="&xsd;string">ADORA1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400018"/>
<dto:entrez_xref>134</dto:entrez_xref>
<dto:geneSymbol>ADORA1</dto:geneSymbol>
<obo:IAO_0000115>An adenosine receptor A1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30542] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200014 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200014">
<rdfs:label rdf:datatype="&xsd;string">ADORA2A gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400018"/>
<dto:entrez_xref>135</dto:entrez_xref>
<dto:geneSymbol>ADORA2A</dto:geneSymbol>
<dto:geneSynonym>ADORA2</dto:geneSynonym>
<obo:IAO_0000115>An adenosine receptor A2a that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29274] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200015 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200015">
<rdfs:label rdf:datatype="&xsd;string">ADORA2B gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400018"/>
<dto:entrez_xref>136</dto:entrez_xref>
<dto:geneSymbol>ADORA2B</dto:geneSymbol>
<obo:IAO_0000115>An adenosine receptor A2b that is encoded in the genome of human. [PRO:WCB, UniProtKB:P29275] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200016 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200016">
<rdfs:label rdf:datatype="&xsd;string">ADORA3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400018"/>
<dto:entrez_xref>140</dto:entrez_xref>
<dto:geneSymbol>ADORA3</dto:geneSymbol>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200017 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200017">
<rdfs:label rdf:datatype="&xsd;string">ACKR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400031"/>
<dto:entrez_xref>2532</dto:entrez_xref>
<dto:geneSymbol>ACKR1</dto:geneSymbol>
<dto:geneSynonym>DARC</dto:geneSynonym>
<dto:geneSynonym>FY</dto:geneSynonym>
<dto:geneSynonym>GPD</dto:geneSynonym>
<obo:IAO_0000115>A duffy antigen/chemokine receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16570] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200018 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200018">
<rdfs:label rdf:datatype="&xsd;string">ACKR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400031"/>
<dto:entrez_xref>1238</dto:entrez_xref>
<dto:geneSymbol>ACKR2</dto:geneSymbol>
<dto:geneSynonym>CCBP2</dto:geneSynonym>
<dto:geneSynonym>CCR10</dto:geneSynonym>
<dto:geneSynonym>CMKBR9</dto:geneSynonym>
<dto:geneSynonym>D6</dto:geneSynonym>
<obo:IAO_0000115>A chemokine-binding protein 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00590] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200019 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200019">
<rdfs:label rdf:datatype="&xsd;string">ACKR3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400031"/>
<dto:entrez_xref>57007</dto:entrez_xref>
<dto:geneSymbol>ACKR3</dto:geneSymbol>
<dto:geneSynonym>CMKOR1</dto:geneSynonym>
<dto:geneSynonym>CXCR7</dto:geneSynonym>
<dto:geneSynonym>GPR159</dto:geneSynonym>
<dto:geneSynonym>RDC1</dto:geneSynonym>
<obo:IAO_0000115>A C-X-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25106] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200020 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200020">
<rdfs:label rdf:datatype="&xsd;string">ACKR4 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400031"/>
<dto:entrez_xref>51554</dto:entrez_xref>
<dto:geneSymbol>ACKR4</dto:geneSymbol>
<dto:geneSynonym>CCBP2</dto:geneSynonym>
<dto:geneSynonym>CCR11</dto:geneSynonym>
<dto:geneSynonym>CCRL1</dto:geneSynonym>
<dto:geneSynonym>VSHK1</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 11 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPB9] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200021 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200021">
<rdfs:label rdf:datatype="&xsd;string">CHRM1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400020"/>
<dto:entrez_xref>1128</dto:entrez_xref>
<dto:geneSymbol>CHRM1</dto:geneSymbol>
<obo:IAO_0000115>A muscarinic acetylcholine receptor M1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P11229] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200022 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200022">
<rdfs:label rdf:datatype="&xsd;string">CHRM2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400020"/>
<dto:entrez_xref>1129</dto:entrez_xref>
<dto:geneSymbol>CHRM2</dto:geneSymbol>
<obo:IAO_0000115>A muscarinic acetylcholine receptor M2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08172] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200023 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200023">
<rdfs:label rdf:datatype="&xsd;string">CHRM3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400020"/>
<dto:entrez_xref>1131</dto:entrez_xref>
<dto:geneSymbol>CHRM3</dto:geneSymbol>
<obo:IAO_0000115>A muscarinic acetylcholine receptor M3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P20309] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200024 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200024">
<rdfs:label rdf:datatype="&xsd;string">CHRM4 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400020"/>
<dto:entrez_xref>1132</dto:entrez_xref>
<dto:geneSymbol>CHRM4</dto:geneSymbol>
<obo:IAO_0000115>A muscarinic acetylcholine receptor M4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08173] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200025 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200025">
<rdfs:label rdf:datatype="&xsd;string">CHRM5 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400020"/>
<dto:entrez_xref>1133</dto:entrez_xref>
<dto:geneSymbol>CHRM5</dto:geneSymbol>
<obo:IAO_0000115>A muscarinic acetylcholine receptor M5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08912] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200026 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200026">
<rdfs:label rdf:datatype="&xsd;string">MC2R gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400021"/>
<dto:entrez_xref>4158</dto:entrez_xref>
<dto:geneSymbol>MC2R</dto:geneSymbol>
<dto:geneSynonym>ACTHR</dto:geneSynonym>
<obo:IAO_0000115>An adrenocorticotropic hormone receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q01718] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200027 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200027">
<rdfs:label rdf:datatype="&xsd;string">ADRA1A gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400093"/>
<dto:entrez_xref>148</dto:entrez_xref>
<dto:geneSymbol>ADRA1A</dto:geneSymbol>
<dto:geneSynonym>ADRA1C</dto:geneSynonym>
<obo:IAO_0000115>An alpha-1A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35348] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200028 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200028">
<rdfs:label rdf:datatype="&xsd;string">ADRA1B gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400093"/>
<dto:entrez_xref>147</dto:entrez_xref>
<dto:geneSymbol>ADRA1B</dto:geneSymbol>
<obo:IAO_0000115>An alpha-1B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35368] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200029 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200029">
<rdfs:label rdf:datatype="&xsd;string">ADRA1D gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400093"/>
<dto:entrez_xref>146</dto:entrez_xref>
<dto:geneSymbol>ADRA1D</dto:geneSymbol>
<dto:geneSynonym>ADRA1A</dto:geneSynonym>
<obo:IAO_0000115>An alpha-1D adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25100] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200030 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200030">
<rdfs:label rdf:datatype="&xsd;string">ADRA2A gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400093"/>
<dto:entrez_xref>150</dto:entrez_xref>
<dto:geneSymbol>ADRA2A</dto:geneSymbol>
<dto:geneSynonym>ADRA2R</dto:geneSynonym>
<dto:geneSynonym>ADRAR</dto:geneSynonym>
<obo:IAO_0000115>An alpha-2A adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08913] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200031 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200031">
<rdfs:label rdf:datatype="&xsd;string">ADRA2B gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400093"/>
<dto:entrez_xref>151</dto:entrez_xref>
<dto:geneSymbol>ADRA2B</dto:geneSymbol>
<dto:geneSynonym>ADRA2L1</dto:geneSynonym>
<dto:geneSynonym>ADRA2RL1</dto:geneSynonym>
<obo:IAO_0000115>An alpha-2B adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18089] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200032 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200032">
<rdfs:label rdf:datatype="&xsd;string">ADRA2C gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400093"/>
<dto:entrez_xref>152</dto:entrez_xref>
<dto:geneSymbol>ADRA2C</dto:geneSymbol>
<dto:geneSynonym>ADRA2L2</dto:geneSynonym>
<dto:geneSynonym>ADRA2RL2</dto:geneSynonym>
<obo:IAO_0000115>An alpha-2C adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P18825] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200033 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200033">
<rdfs:label rdf:datatype="&xsd;string">ADRB1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400094"/>
<dto:entrez_xref>153</dto:entrez_xref>
<dto:geneSymbol>ADRB1</dto:geneSymbol>
<dto:geneSynonym>ADRB1R</dto:geneSynonym>
<dto:geneSynonym>B1AR</dto:geneSynonym>
<obo:IAO_0000115>A beta-1 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P08588] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200034 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200034">
<rdfs:label rdf:datatype="&xsd;string">ADRB2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400094"/>
<dto:entrez_xref>154</dto:entrez_xref>
<dto:geneSymbol>ADRB2</dto:geneSymbol>
<dto:geneSynonym>ADRB2R</dto:geneSynonym>
<dto:geneSynonym>B2AR</dto:geneSynonym>
<obo:IAO_0000115>A beta-2 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P07550] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200035 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200035">
<rdfs:label rdf:datatype="&xsd;string">ADRB3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400094"/>
<dto:entrez_xref>155</dto:entrez_xref>
<dto:geneSymbol>ADRB3</dto:geneSymbol>
<dto:geneSynonym>ADRB3R</dto:geneSynonym>
<dto:geneSynonym>B3AR</dto:geneSynonym>
<obo:IAO_0000115>A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200036 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200036">
<rdfs:label rdf:datatype="&xsd;string">AGTR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400023"/>
<dto:entrez_xref>185</dto:entrez_xref>
<dto:geneSymbol>AGTR1</dto:geneSymbol>
<dto:geneSynonym>AGTR1A</dto:geneSynonym>
<dto:geneSynonym>AGTR1B</dto:geneSynonym>
<dto:geneSynonym>AT2R1</dto:geneSynonym>
<dto:geneSynonym>AT2R1B</dto:geneSynonym>
<obo:IAO_0000115>An angiotensin II receptor 1A that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30556] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200037 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200037">
<rdfs:label rdf:datatype="&xsd;string">AGTR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400023"/>
<dto:entrez_xref>186</dto:entrez_xref>
<dto:geneSymbol>AGTR2</dto:geneSymbol>
<obo:IAO_0000115>An angiotensin II receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P50052] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200038 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200038">
<rdfs:label rdf:datatype="&xsd;string">APLNR gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400024"/>
<dto:entrez_xref>187</dto:entrez_xref>
<dto:geneSymbol>APLNR</dto:geneSymbol>
<dto:geneSynonym>AGTRL1</dto:geneSynonym>
<dto:geneSynonym>APJ</dto:geneSynonym>
<obo:IAO_0000115>An apelin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35414] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200039 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200039">
<rdfs:label rdf:datatype="&xsd;string">ADGRB1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402008"/>
<dto:entrez_xref>575</dto:entrez_xref>
<dto:geneSymbol>BAI1</dto:geneSymbol>
<obo:IAO_0000115>A brain-specific angiogenesis inhibitor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14514] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200040 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200040">
<rdfs:label rdf:datatype="&xsd;string">ADGRB2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402008"/>
<dto:entrez_xref>576</dto:entrez_xref>
<dto:geneSymbol>BAI2</dto:geneSymbol>
<obo:IAO_0000115>A brain-specific angiogenesis inhibitor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60241] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200041 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200041">
<rdfs:label rdf:datatype="&xsd;string">ADGRB3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402008"/>
<dto:entrez_xref>577</dto:entrez_xref>
<dto:geneSymbol>BAI3</dto:geneSymbol>
<dto:geneSynonym>KIAA0550</dto:geneSynonym>
<obo:IAO_0000115>A brain-specific angiogenesis inhibitor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60242] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200042 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200042">
<rdfs:label rdf:datatype="&xsd;string">BDKRB1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400025"/>
<dto:entrez_xref>623</dto:entrez_xref>
<dto:geneSymbol>BDKRB1</dto:geneSymbol>
<dto:geneSynonym>BRADYB1</dto:geneSynonym>
<obo:IAO_0000115>A B1 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46663] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200043 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200043">
<rdfs:label rdf:datatype="&xsd;string">BDKRB2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400025"/>
<dto:entrez_xref>624</dto:entrez_xref>
<dto:geneSymbol>BDKRB2</dto:geneSymbol>
<dto:geneSynonym>BKR2</dto:geneSynonym>
<obo:IAO_0000115>A B2 bradykinin receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P30411] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200044 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200044">
<rdfs:label rdf:datatype="&xsd;string">BRS3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400026"/>
<dto:entrez_xref>680</dto:entrez_xref>
<dto:geneSymbol>BRS3</dto:geneSymbol>
<obo:IAO_0000115>A bombesin receptor subtype-3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32247] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200045 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200045">
<rdfs:label rdf:datatype="&xsd;string">C3AR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400027"/>
<dto:entrez_xref>719</dto:entrez_xref>
<dto:geneSymbol>C3AR1</dto:geneSymbol>
<dto:geneSynonym>AZ3B</dto:geneSynonym>
<dto:geneSynonym>C3R1</dto:geneSynonym>
<dto:geneSynonym>HNFAG09</dto:geneSynonym>
<obo:IAO_0000115>A C3a anaphylatoxin chemotactic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q16581] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200046 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200046">
<rdfs:label rdf:datatype="&xsd;string">C5AR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400027"/>
<dto:entrez_xref>728</dto:entrez_xref>
<dto:geneSymbol>C5AR1</dto:geneSymbol>
<dto:geneSynonym>C5AR</dto:geneSynonym>
<dto:geneSynonym>C5R1</dto:geneSynonym>
<obo:IAO_0000115>A C5a anaphylatoxin chemotactic receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21730] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200047 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200047">
<rdfs:label rdf:datatype="&xsd;string">C5AR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400027"/>
<dto:entrez_xref>27202</dto:entrez_xref>
<dto:geneSymbol>C5AR2</dto:geneSymbol>
<dto:geneSynonym>C5L2</dto:geneSynonym>
<dto:geneSynonym>GPR77</dto:geneSynonym>
<obo:IAO_0000115>A C5a anaphylatoxin chemotactic receptor C5L2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9P296] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200048 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200048">
<rdfs:label rdf:datatype="&xsd;string">CALCR gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400028"/>
<dto:entrez_xref>799</dto:entrez_xref>
<dto:geneSymbol>CALCR</dto:geneSymbol>
<obo:IAO_0000115>A calcitonin receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30988] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200049 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200049">
<rdfs:label rdf:datatype="&xsd;string">CALCRL gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400028"/>
<dto:entrez_xref>10203</dto:entrez_xref>
<dto:geneSymbol>CALCRL</dto:geneSymbol>
<dto:geneSynonym>CGRPR</dto:geneSynonym>
<obo:IAO_0000115>A calcitonin gene-related peptide type 1 receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q16602] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200050 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200050">
<rdfs:label rdf:datatype="&xsd;string">CASR gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400029"/>
<dto:entrez_xref>846</dto:entrez_xref>
<dto:geneSymbol>CASR</dto:geneSymbol>
<dto:geneSynonym>GPRC2A</dto:geneSynonym>
<dto:geneSynonym>PCAR1</dto:geneSynonym>
<obo:IAO_0000115>An extracellular calcium-sensing receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P41180] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200051 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200051">
<rdfs:label rdf:datatype="&xsd;string">CCKAR gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400030"/>
<dto:entrez_xref>886</dto:entrez_xref>
<dto:geneSymbol>CCKAR</dto:geneSymbol>
<dto:geneSynonym>CCKRA</dto:geneSynonym>
<obo:IAO_0000115>A cholecystokinin receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32238] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200052 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200052">
<rdfs:label rdf:datatype="&xsd;string">CCR10 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>2826</dto:entrez_xref>
<dto:geneSymbol>CCR10</dto:geneSymbol>
<dto:geneSynonym>GPR2</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 10 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P46092] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200053 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200053">
<rdfs:label rdf:datatype="&xsd;string">CCR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1230</dto:entrez_xref>
<dto:geneSymbol>CCR1</dto:geneSymbol>
<dto:geneSynonym>CMKBR1</dto:geneSynonym>
<dto:geneSynonym>CMKR1</dto:geneSynonym>
<dto:geneSynonym>SCYAR1</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32246] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200054 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200054">
<rdfs:label rdf:datatype="&xsd;string">CCR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>729230</dto:entrez_xref>
<dto:geneSymbol>CCR2</dto:geneSymbol>
<dto:geneSynonym>CMKBR2</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P41597] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200055 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200055">
<rdfs:label rdf:datatype="&xsd;string">CCR3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1232</dto:entrez_xref>
<dto:geneSymbol>CCR3</dto:geneSymbol>
<dto:geneSynonym>CMKBR3</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51677] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200056 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200056">
<rdfs:label rdf:datatype="&xsd;string">CCR4 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1233</dto:entrez_xref>
<dto:geneSymbol>CCR4</dto:geneSymbol>
<dto:geneSynonym>CMKBR4</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200057 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200057">
<rdfs:label rdf:datatype="&xsd;string">CCR5 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1234</dto:entrez_xref>
<dto:geneSymbol>CCR5</dto:geneSymbol>
<dto:geneSynonym>CMKBR5</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51681] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200058 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200058">
<rdfs:label rdf:datatype="&xsd;string">CCR6 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1235</dto:entrez_xref>
<dto:geneSymbol>CCR6</dto:geneSymbol>
<dto:geneSynonym>CKRL3</dto:geneSynonym>
<dto:geneSynonym>CMKBR6</dto:geneSynonym>
<dto:geneSynonym>GPR29</dto:geneSynonym>
<dto:geneSynonym>STRL22</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51684] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200059 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200059">
<rdfs:label rdf:datatype="&xsd;string">CCR7 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1236</dto:entrez_xref>
<dto:geneSymbol>CCR7</dto:geneSymbol>
<dto:geneSynonym>CMKBR7</dto:geneSynonym>
<dto:geneSynonym>EBI1</dto:geneSynonym>
<dto:geneSynonym>EVI1</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32248] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200060 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200060">
<rdfs:label rdf:datatype="&xsd;string">CCR8 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>1237</dto:entrez_xref>
<dto:geneSymbol>CCR8</dto:geneSymbol>
<dto:geneSynonym>CKRL1</dto:geneSynonym>
<dto:geneSynonym>CMKBR8</dto:geneSynonym>
<dto:geneSynonym>CMKBRL2</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 8 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51685] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200061 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200061">
<rdfs:label rdf:datatype="&xsd;string">CCR9 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>10803</dto:entrez_xref>
<dto:geneSymbol>CCR9</dto:geneSymbol>
<dto:geneSynonym>GPR28</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor type 9 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51686] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200062 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200062">
<rdfs:label rdf:datatype="&xsd;string">CCRL2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400095"/>
<dto:entrez_xref>9034</dto:entrez_xref>
<dto:geneSymbol>CCRL2</dto:geneSymbol>
<dto:geneSynonym>CCR11</dto:geneSynonym>
<dto:geneSynonym>CCR6</dto:geneSynonym>
<dto:geneSynonym>CKRX</dto:geneSynonym>
<dto:geneSynonym>CRAM</dto:geneSynonym>
<dto:geneSynonym>HCR</dto:geneSynonym>
<obo:IAO_0000115>A C-C chemokine receptor-like 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O00421] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200063 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200063">
<rdfs:label rdf:datatype="&xsd;string">ADGRE5 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02402008"/>
<dto:entrez_xref>976</dto:entrez_xref>
<dto:geneSymbol>CD97</dto:geneSymbol>
<obo:IAO_0000115>A CD97 molecule that is encoded in the genome of human. [PRO:WCB, UniProtKB:P48960] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200064 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200064">
<rdfs:label rdf:datatype="&xsd;string">CELSR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400032"/>
<dto:entrez_xref>9620</dto:entrez_xref>
<dto:geneSymbol>CELSR1</dto:geneSymbol>
<dto:geneSynonym>CDHF9</dto:geneSynonym>
<dto:geneSynonym>FMI2</dto:geneSynonym>
<obo:IAO_0000115>A cadherin EGF LAG seven-pass G-type receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ6] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200065 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200065">
<rdfs:label rdf:datatype="&xsd;string">CELSR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400032"/>
<dto:entrez_xref>1952</dto:entrez_xref>
<dto:geneSymbol>CELSR2</dto:geneSymbol>
<dto:geneSynonym>CDHF10</dto:geneSynonym>
<dto:geneSynonym>EGFL2</dto:geneSynonym>
<dto:geneSynonym>KIAA0279</dto:geneSynonym>
<dto:geneSynonym>MEGF3</dto:geneSynonym>
<obo:IAO_0000115>A cadherin EGF LAG seven-pass G-type receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HCU4] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200066 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200066">
<rdfs:label rdf:datatype="&xsd;string">CELSR3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400032"/>
<dto:entrez_xref>1951</dto:entrez_xref>
<dto:geneSymbol>CELSR3</dto:geneSymbol>
<dto:geneSynonym>CDHF11</dto:geneSynonym>
<dto:geneSynonym>EGFL1</dto:geneSynonym>
<dto:geneSynonym>FMI1</dto:geneSynonym>
<dto:geneSynonym>KIAA0812</dto:geneSynonym>
<dto:geneSynonym>MEGF2</dto:geneSynonym>
<obo:IAO_0000115>A cadherin EGF LAG seven-pass G-type receptor 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NYQ7] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200067 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200067">
<rdfs:label rdf:datatype="&xsd;string">CYSLTR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400033"/>
<dto:entrez_xref>10800</dto:entrez_xref>
<dto:geneSymbol>CYSLTR1</dto:geneSymbol>
<dto:geneSynonym>CYSLT1</dto:geneSynonym>
<obo:IAO_0000115>A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200068 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200068">
<rdfs:label rdf:datatype="&xsd;string">CYSLTR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400033"/>
<dto:entrez_xref>57105</dto:entrez_xref>
<dto:geneSymbol>CYSLTR2</dto:geneSymbol>
<dto:geneSynonym>CYSLT2</dto:geneSynonym>
<dto:geneSynonym>CYSLT2R</dto:geneSynonym>
<obo:IAO_0000115>A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200069 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200069">
<rdfs:label rdf:datatype="&xsd;string">CMKLR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400034"/>
<dto:entrez_xref>1240</dto:entrez_xref>
<dto:geneSymbol>CMKLR1</dto:geneSymbol>
<dto:geneSynonym>CHEMR23</dto:geneSynonym>
<dto:geneSynonym>DEZ</dto:geneSynonym>
<obo:IAO_0000115>A chemokine receptor-like protein CMKLR1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q99788] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200070 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200070">
<rdfs:label rdf:datatype="&xsd;string">CNR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400035"/>
<dto:entrez_xref>1268</dto:entrez_xref>
<dto:geneSymbol>CNR1</dto:geneSymbol>
<dto:geneSynonym>CNR</dto:geneSynonym>
<obo:IAO_0000115>A cannabinoid receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21554] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200071 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200071">
<rdfs:label rdf:datatype="&xsd;string">CNR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400035"/>
<dto:entrez_xref>1269</dto:entrez_xref>
<dto:geneSymbol>CNR2</dto:geneSymbol>
<dto:geneSynonym>CB2A</dto:geneSynonym>
<dto:geneSynonym>CB2B</dto:geneSynonym>
<obo:IAO_0000115>A cannabinoid receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34972] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200072 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200072">
<rdfs:label rdf:datatype="&xsd;string">CRHR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400036"/>
<dto:entrez_xref>1394</dto:entrez_xref>
<dto:geneSymbol>CRHR1</dto:geneSymbol>
<dto:geneSynonym>CRFR</dto:geneSynonym>
<dto:geneSynonym>CRFR1</dto:geneSynonym>
<dto:geneSynonym>CRHR</dto:geneSynonym>
<obo:IAO_0000115>A corticotropin-releasing factor receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34998] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200073 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200073">
<rdfs:label rdf:datatype="&xsd;string">CRHR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400036"/>
<dto:entrez_xref>1395</dto:entrez_xref>
<dto:geneSymbol>CRHR2</dto:geneSymbol>
<dto:geneSynonym>CRF2R</dto:geneSynonym>
<dto:geneSynonym>CRH2R</dto:geneSynonym>
<obo:IAO_0000115>A corticotropin-releasing factor receptor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13324] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200074 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200074">
<rdfs:label rdf:datatype="&xsd;string">CX3CR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400096"/>
<dto:entrez_xref>1524</dto:entrez_xref>
<dto:geneSymbol>CX3CR1</dto:geneSymbol>
<dto:geneSynonym>CMKBRL1</dto:geneSynonym>
<dto:geneSynonym>GPR13</dto:geneSynonym>
<obo:IAO_0000115>A CX3C chemokine receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49238] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200075 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200075">
<rdfs:label rdf:datatype="&xsd;string">CXCR1 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400031"/>
<dto:entrez_xref>3577</dto:entrez_xref>
<dto:geneSymbol>CXCR1</dto:geneSymbol>
<dto:geneSynonym>CMKAR1</dto:geneSynonym>
<dto:geneSynonym>IL8RA</dto:geneSynonym>
<obo:IAO_0000115>A C-X-C chemokine receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25024] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200076 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200076">
<rdfs:label rdf:datatype="&xsd;string">CXCR2 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400031"/>
<dto:entrez_xref>3579</dto:entrez_xref>
<dto:geneSymbol>CXCR2</dto:geneSymbol>
<dto:geneSynonym>IL8RB</dto:geneSynonym>
<obo:IAO_0000115>A C-X-C chemokine receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25025] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200077 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200077">
<rdfs:label rdf:datatype="&xsd;string">CXCR3 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400097"/>
<dto:entrez_xref>2833</dto:entrez_xref>
<dto:geneSymbol>CXCR3</dto:geneSymbol>
<dto:geneSynonym>GPR9</dto:geneSynonym>
<obo:IAO_0000115>A C-X-C chemokine receptor type 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P49682] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200078 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200078">
<rdfs:label rdf:datatype="&xsd;string">CXCR4 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400097"/>
<dto:entrez_xref>7852</dto:entrez_xref>
<dto:geneSymbol>CXCR4</dto:geneSymbol>
<obo:IAO_0000115>A C-X-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P61073] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200079 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200079">
<rdfs:label rdf:datatype="&xsd;string">CXCR5 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400097"/>
<dto:entrez_xref>643</dto:entrez_xref>
<dto:geneSymbol>CXCR5</dto:geneSymbol>
<dto:geneSynonym>BLR1</dto:geneSynonym>
<dto:geneSynonym>MDR15</dto:geneSynonym>
<obo:IAO_0000115>A C-X-C chemokine receptor type 5 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P32302] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200080 -->
<owl:Class rdf:about="http://www.drugtargetontology.org/dto/DTO_02200080">
<rdfs:label rdf:datatype="&xsd;string">CXCR6 gene</rdfs:label>
<rdfs:subClassOf rdf:resource="http://www.drugtargetontology.org/dto/DTO_02400097"/>
<dto:entrez_xref>10663</dto:entrez_xref>
<dto:geneSymbol>CXCR6</dto:geneSymbol>
<dto:geneSynonym>BONZO</dto:geneSynonym>
<dto:geneSynonym>STRL33</dto:geneSynonym>
<dto:geneSynonym>TYMSTR</dto:geneSynonym>
<obo:IAO_0000115>A C-X-C chemokine receptor type 6 that is encoded in the genome of human. [PRO:CNx, Reactome:REACT_14906] </obo:IAO_0000115>
</owl:Class>
<!-- http://www.drugtargetontology.org/dto/DTO_02200081 -->