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DESCRIPTION
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DESCRIPTION
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Package: lrcde
Title: Linear Regression Cell Type-Specific Differential Expression Power
Analysis
Version: 1.0.1.0000
Authors@R: c(person("Edmund", "Glass", email = "Edmund.Glass@gmail.com", role = c("aut", "cre")),
person("Mikhail", "Dozmorov", email = "Mikhail.Dozmorov@gmail.com", role = c("aut", "ctb", "ths")))
Description: Linear Regression Cell Type-Specific Differential Expression Power
Analysis. Feeding lrcde a samples by genomic sites matrix of heterogeneous
expression measures, cell proportions, and a group membership vector, then
cell type-specific expression is estimated using linear regression per group.
Differences are take between group-wise estiamates per cell type per genomic
site. Power is calculated for per cell type per gene for each difference
estimate based on standard errors of coefficient estiamtes.
Depends:
License: Free
Encoding: UTF-8
LazyData: true
RoxygenNote: 5.0.1
Imports:
dplyr,
pROC,
knitr
Suggests: rmarkdown
VignetteBuilder: knitr