This work is a close collaboration between the groups of Prof. Victor Greiff and Prof. Geir Kjetil Sandve (University of Oslo, Norway), Prof. Sai Reddy ETH Zurich, Switzerland), and the group of Dr. Xiao Liu (Beijing Genomics Institute in Shenzhen, China). In addition to all co-authors, we would like to thank in particular Milena Pavlovic, Andrei Slabodkin, Mariia Chernigovskaya, Lonneke Scheffer for package testing and feedback on the manuscript.