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Procedure adds new code systems in 6.1.0 that would technically have needed to be accompanied by a SNOMED code in 3.1.1. However, no one seems to have interpreted the Extensible binding as meaning that, so probably doesn't matter.
Laboratory observation prohibits effectivePeriod and tightens value to Quantity, CodeableConcept, String
MedicationRequest did allow Patient and Organization as requester. Now it's just Practitioner - is that ok?
MedicationRequest.requester prohibits PractitionerRole and only allows Practitioner