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Genome Aggregation Database (gnomAD)
Learn how to use the Genome Aggregation Database (gnomAD) dataset in Azure Open Datasets.
open-datasets
sample
04/16/2021

Genome Aggregation Database (gnomAD)

The Genome Aggregation Database (gnomAD) is a resource developed by an international coalition of investigators, with the goal of aggregating and harmonizing both exome and genome sequencing data from a wide variety of large-scale sequencing projects, and making summary data available for the wider scientific community.

[!INCLUDE Open Dataset usage notice]

Data source

This dataset is hosted as a collaboration with the Broad Institute and the full gnomAD data catalog can be seen at https://gnomad.broadinstitute.org/downloads

Data volumes and update frequency

This dataset contains approximately 30 TB of data and is updated with each gnomAD release.

Storage location

The Storage Account hosting this dataset is in the East US Azure region. Allocating compute resources in East US is recommended for affinity.

Data Access

Storage Account: 'https://datasetgnomad.blob.core.windows.net/dataset/'

The data is available publicly without restrictions, and the AzCopy tool is recommended for bulk operations. For example, to view the VCFs in release 3.0 of gnomAD:

$ azcopy ls https://datasetgnomad.blob.core.windows.net/dataset/release/3.0/vcf/genomes

To download all the VCFs recursively:

$ azcopy cp --recursive=true https://datasetgnomad.blob.core.windows.net/dataset/release/3.0/vcf/genomes .

NEW: Parquet format of gnomAD v2.1.1 VCF files (exomes and genomes)

To view the parquet files:

$ azcopy ls https://datasetgnomadparquet.blob.core.windows.net/dataset

To download all the parquet files recursively:

$ cp --recursive=true https://datasetgnomadparquet.blob.core.windows.net/dataset

The Azure Storage Explorer is also a useful tool for browsing the list of files in the gnomAD release.

Use Terms

Data is available without restrictions. For more information and citation details, see the gnomAD about page.

Contact

For any questions or feedback about this dataset, contact the gnomAD team.

Next steps

View the rest of the datasets in the Open Datasets catalog.