jobgraph_including_ClonalFrameML.svg

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<!-- Title: snakemake_dag Pages: 1 -->
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<!-- 39 -->
<g id="node40" class="node"><title>39</title>
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<!-- 0&#45;&gt;39 -->
<g id="edge79" class="edge"><title>0&#45;&gt;39</title>
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<!-- 1 -->
<g id="node2" class="node"><title>1</title>
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<text text-anchor="middle" x="1094" y="-303.5" font-family="sans" font-size="10.00">summary_stats</text>
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<!-- 1&#45;&gt;39 -->
<g id="edge80" class="edge"><title>1&#45;&gt;39</title>
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<!-- 2 -->
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<text text-anchor="middle" x="848" y="-1095.5" font-family="sans" font-size="10.00">extract_low_coverage_positions</text>
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<!-- 20 -->
<g id="node21" class="node"><title>20</title>
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<text text-anchor="middle" x="720" y="-1023.5" font-family="sans" font-size="10.00">filter_coverage</text>
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<!-- 2&#45;&gt;20 -->
<g id="edge44" class="edge"><title>2&#45;&gt;20</title>
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<!-- 3 -->
<g id="node4" class="node"><title>3</title>
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<text text-anchor="middle" x="555" y="-951.5" font-family="sans" font-size="10.00">create_all_position_bed_file</text>
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<!-- 23 -->
<g id="node24" class="node"><title>23</title>
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<text text-anchor="middle" x="506" y="-879.5" font-family="sans" font-size="10.00">AF_by_position_calculation</text>
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<!-- 3&#45;&gt;23 -->
<g id="edge51" class="edge"><title>3&#45;&gt;23</title>
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<!-- 24 -->
<g id="node25" class="node"><title>24</title>
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<text text-anchor="middle" x="349" y="-879.5" font-family="sans" font-size="10.00">AF_by_position_calculation</text>
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<!-- 3&#45;&gt;24 -->
<g id="edge54" class="edge"><title>3&#45;&gt;24</title>
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<!-- 30 -->
<g id="node31" class="node"><title>30</title>
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<!-- 3&#45;&gt;30 -->
<g id="edge63" class="edge"><title>3&#45;&gt;30</title>
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<!-- 47 -->
<g id="node48" class="node"><title>47</title>
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<text text-anchor="middle" x="874" y="-879.5" font-family="sans" font-size="10.00">AF_by_position_calculation</text>
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<!-- 3&#45;&gt;47 -->
<g id="edge101" class="edge"><title>3&#45;&gt;47</title>
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<!-- 4 -->
<g id="node5" class="node"><title>4</title>
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<text text-anchor="middle" x="741" y="-1311.5" font-family="sans" font-size="10.00">merge_vcfs</text>
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<!-- 10 -->
<g id="node11" class="node"><title>10</title>
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<text text-anchor="middle" x="741" y="-1239.5" font-family="sans" font-size="10.00">filter_out_same_variants</text>
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<!-- 4&#45;&gt;10 -->
<g id="edge27" class="edge"><title>4&#45;&gt;10</title>
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<!-- 5 -->
<g id="node6" class="node"><title>5</title>
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<text text-anchor="middle" x="928" y="-309" font-family="sans" font-size="10.00">split_final_vcf_clonalframe</text>
<text text-anchor="middle" x="928" y="-298" font-family="sans" font-size="10.00">sample: fourth_isolate</text>
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<!-- 19 -->
<g id="node20" class="node"><title>19</title>
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<text text-anchor="middle" x="979" y="-231.5" font-family="sans" font-size="10.00">create_fasta_for_vcf_clonalframe</text>
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<!-- 5&#45;&gt;19 -->
<g id="edge43" class="edge"><title>5&#45;&gt;19</title>
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<!-- 6 -->
<g id="node7" class="node"><title>6</title>
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<text text-anchor="middle" x="1022" y="-1095.5" font-family="sans" font-size="10.00">extract_low_coverage_positions</text>
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<!-- 36 -->
<g id="node37" class="node"><title>36</title>
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<text text-anchor="middle" x="832" y="-1023.5" font-family="sans" font-size="10.00">filter_coverage</text>
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<!-- 6&#45;&gt;36 -->
<g id="edge74" class="edge"><title>6&#45;&gt;36</title>
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<!-- 7 -->
<g id="node8" class="node"><title>7</title>
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<text text-anchor="middle" x="354" y="-519.5" font-family="sans" font-size="10.00">generate_raxml_tree</text>
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<!-- 29 -->
<g id="node30" class="node"><title>29</title>
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<text text-anchor="middle" x="414" y="-447.5" font-family="sans" font-size="10.00">run_clonal_frame</text>
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<!-- 7&#45;&gt;29 -->
<g id="edge59" class="edge"><title>7&#45;&gt;29</title>
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<!-- 7&#45;&gt;39 -->
<g id="edge85" class="edge"><title>7&#45;&gt;39</title>
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<!-- 8 -->
<g id="node9" class="node"><title>8</title>
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<text text-anchor="middle" x="778" y="-309" font-family="sans" font-size="10.00">split_final_vcf_clonalframe</text>
<text text-anchor="middle" x="778" y="-298" font-family="sans" font-size="10.00">sample: third_isolate</text>
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<!-- 46 -->
<g id="node47" class="node"><title>46</title>
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<text text-anchor="middle" x="800" y="-231.5" font-family="sans" font-size="10.00">create_fasta_for_vcf_clonalframe</text>
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<!-- 8&#45;&gt;46 -->
<g id="edge97" class="edge"><title>8&#45;&gt;46</title>
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<!-- 9 -->
<g id="node10" class="node"><title>9</title>
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<text text-anchor="middle" x="582" y="-231.5" font-family="sans" font-size="10.00">create_fasta_for_vcf_clonalframe</text>
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<!-- 44 -->
<g id="node45" class="node"><title>44</title>
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<text text-anchor="middle" x="582" y="-159.5" font-family="sans" font-size="10.00">create_multi_fasta_clonalframe</text>
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<!-- 9&#45;&gt;44 -->
<g id="edge93" class="edge"><title>9&#45;&gt;44</title>
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<!-- 16 -->
<g id="node17" class="node"><title>16</title>
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<text text-anchor="middle" x="785" y="-1167.5" font-family="sans" font-size="10.00">create_all_position_bed</text>
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<!-- 10&#45;&gt;16 -->
<g id="edge39" class="edge"><title>10&#45;&gt;16</title>
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<!-- 22 -->
<g id="node23" class="node"><title>22</title>
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<text text-anchor="middle" x="697" y="-1095.5" font-family="sans" font-size="10.00">copy_input_to_output</text>
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<!-- 10&#45;&gt;22 -->
<g id="edge48" class="edge"><title>10&#45;&gt;22</title>
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<!-- 11 -->
<g id="node12" class="node"><title>11</title>
<path fill="none" stroke="#97d856" stroke-width="2" stroke-dasharray="5,2" d="M509.25,-612C509.25,-612 436.75,-612 436.75,-612 430.75,-612 424.75,-606 424.75,-600 424.75,-600 424.75,-588 424.75,-588 424.75,-582 430.75,-576 436.75,-576 436.75,-576 509.25,-576 509.25,-576 515.25,-576 521.25,-582 521.25,-588 521.25,-588 521.25,-600 521.25,-600 521.25,-606 515.25,-612 509.25,-612"/>
<text text-anchor="middle" x="473" y="-591.5" font-family="sans" font-size="10.00">create_multi_fasta</text>
</g>
<!-- 11&#45;&gt;0 -->
<g id="edge1" class="edge"><title>11&#45;&gt;0</title>
<path fill="none" stroke="grey" stroke-width="2" d="M424.411,-581.762C387.412,-572.494 335.591,-557.971 292,-540 246.146,-521.096 196.479,-492.97 163.961,-473.414"/>
<polygon fill="grey" stroke="grey" points="165.628,-470.331 155.262,-468.14 161.999,-476.317 165.628,-470.331"/>
</g>
<!-- 11&#45;&gt;7 -->
<g id="edge23" class="edge"><title>11&#45;&gt;7</title>
<path fill="none" stroke="grey" stroke-width="2" d="M443.889,-575.876C428.33,-566.724 408.981,-555.342 392.224,-545.485"/>
<polygon fill="grey" stroke="grey" points="393.617,-542.243 383.223,-540.19 390.067,-548.277 393.617,-542.243"/>
</g>
<!-- 11&#45;&gt;29 -->
<g id="edge60" class="edge"><title>11&#45;&gt;29</title>
<path fill="none" stroke="grey" stroke-width="2" d="M465.883,-575.871C455.739,-551.457 437.029,-506.426 425.067,-477.635"/>
<polygon fill="grey" stroke="grey" points="428.211,-476.081 421.142,-468.189 421.747,-478.767 428.211,-476.081"/>
</g>
<!-- 43 -->
<g id="node44" class="node"><title>43</title>
<path fill="none" stroke="#5682d8" stroke-width="2" stroke-dasharray="5,2" d="M1392,-396C1392,-396 1242,-396 1242,-396 1236,-396 1230,-390 1230,-384 1230,-384 1230,-372 1230,-372 1230,-366 1236,-360 1242,-360 1242,-360 1392,-360 1392,-360 1398,-360 1404,-366 1404,-372 1404,-372 1404,-384 1404,-384 1404,-390 1398,-396 1392,-396"/>
<text text-anchor="middle" x="1317" y="-375.5" font-family="sans" font-size="10.00">generate_raxml_tree_with_reference</text>
</g>
<!-- 11&#45;&gt;43 -->
<g id="edge92" class="edge"><title>11&#45;&gt;43</title>
<path fill="none" stroke="grey" stroke-width="2" d="M521.49,-589.971C597.947,-584.452 750.803,-570.404 877,-540 969.659,-517.676 989.472,-500.693 1079,-468 1142,-444.996 1214.1,-417.927 1262.29,-399.734"/>
<polygon fill="grey" stroke="grey" points="1263.78,-402.913 1271.89,-396.104 1261.3,-396.364 1263.78,-402.913"/>
</g>
<!-- 12 -->
<g id="node13" class="node"><title>12</title>
<path fill="none" stroke="#56d882" stroke-width="2" stroke-dasharray="5,2" d="M574,-1044C574,-1044 518,-1044 518,-1044 512,-1044 506,-1038 506,-1032 506,-1032 506,-1020 506,-1020 506,-1014 512,-1008 518,-1008 518,-1008 574,-1008 574,-1008 580,-1008 586,-1014 586,-1020 586,-1020 586,-1032 586,-1032 586,-1038 580,-1044 574,-1044"/>
<text text-anchor="middle" x="546" y="-1023.5" font-family="sans" font-size="10.00">filter_coverage</text>
</g>
<!-- 12&#45;&gt;3 -->
<g id="edge15" class="edge"><title>12&#45;&gt;3</title>
<path fill="none" stroke="grey" stroke-width="2" d="M548.225,-1007.7C549.217,-999.983 550.408,-990.712 551.514,-982.112"/>
<polygon fill="grey" stroke="grey" points="554.997,-982.469 552.801,-972.104 548.054,-981.576 554.997,-982.469"/>
</g>
<!-- 12&#45;&gt;23 -->
<g id="edge49" class="edge"><title>12&#45;&gt;23</title>
<path fill="none" stroke="grey" stroke-width="2" d="M512.164,-1007.96C498.621,-999.216 484.479,-987.175 477,-972 467.028,-951.767 476.396,-927.31 487.062,-909.158"/>
<polygon fill="grey" stroke="grey" points="490.279,-910.619 492.663,-900.296 484.362,-906.879 490.279,-910.619"/>
</g>
<!-- 13 -->
<g id="node14" class="node"><title>13</title>
<path fill="none" stroke="#56d882" stroke-width="2" stroke-dasharray="5,2" d="M438,-1044C438,-1044 382,-1044 382,-1044 376,-1044 370,-1038 370,-1032 370,-1032 370,-1020 370,-1020 370,-1014 376,-1008 382,-1008 382,-1008 438,-1008 438,-1008 444,-1008 450,-1014 450,-1020 450,-1020 450,-1032 450,-1032 450,-1038 444,-1044 438,-1044"/>
<text text-anchor="middle" x="410" y="-1023.5" font-family="sans" font-size="10.00">filter_coverage</text>
</g>
<!-- 13&#45;&gt;3 -->
<g id="edge11" class="edge"><title>13&#45;&gt;3</title>
<path fill="none" stroke="grey" stroke-width="2" d="M445.471,-1007.88C465.117,-998.392 489.722,-986.513 510.632,-976.419"/>
<polygon fill="grey" stroke="grey" points="512.16,-979.568 519.644,-972.068 509.117,-973.264 512.16,-979.568"/>
</g>
<!-- 13&#45;&gt;24 -->
<g id="edge52" class="edge"><title>13&#45;&gt;24</title>
<path fill="none" stroke="grey" stroke-width="2" d="M402.642,-1007.87C392.154,-983.457 372.81,-938.426 360.442,-909.635"/>
<polygon fill="grey" stroke="grey" points="363.547,-907.996 356.384,-900.189 357.115,-910.759 363.547,-907.996"/>
</g>
<!-- 14 -->
<g id="node15" class="node"><title>14</title>
<path fill="none" stroke="#56d89a" stroke-width="2" stroke-dasharray="5,2" d="M471.25,-252C471.25,-252 334.75,-252 334.75,-252 328.75,-252 322.75,-246 322.75,-240 322.75,-240 322.75,-228 322.75,-228 322.75,-222 328.75,-216 334.75,-216 334.75,-216 471.25,-216 471.25,-216 477.25,-216 483.25,-222 483.25,-228 483.25,-228 483.25,-240 483.25,-240 483.25,-246 477.25,-252 471.25,-252"/>
<text text-anchor="middle" x="403" y="-231.5" font-family="sans" font-size="10.00">create_fasta_for_vcf_clonalframe</text>
</g>
<!-- 14&#45;&gt;44 -->
<g id="edge94" class="edge"><title>14&#45;&gt;44</title>
<path fill="none" stroke="grey" stroke-width="2" d="M446.788,-215.876C471.585,-206.179 502.781,-193.98 528.958,-183.743"/>
<polygon fill="grey" stroke="grey" points="530.315,-186.97 538.354,-180.068 527.766,-180.451 530.315,-186.97"/>
</g>
<!-- 15 -->
<g id="node16" class="node"><title>15</title>
<path fill="none" stroke="#56c1d8" stroke-width="2" stroke-dasharray="5,2" d="M569.25,-108C569.25,-108 414.75,-108 414.75,-108 408.75,-108 402.75,-102 402.75,-96 402.75,-96 402.75,-84 402.75,-84 402.75,-78 408.75,-72 414.75,-72 414.75,-72 569.25,-72 569.25,-72 575.25,-72 581.25,-78 581.25,-84 581.25,-84 581.25,-96 581.25,-96 581.25,-102 575.25,-108 569.25,-108"/>
<text text-anchor="middle" x="492" y="-87.5" font-family="sans" font-size="10.00">calculate_snp_distances_clonalframe</text>
</g>
<!-- 15&#45;&gt;39 -->
<g id="edge84" class="edge"><title>15&#45;&gt;39</title>
<path fill="none" stroke="grey" stroke-width="2" d="M457.997,-71.8761C437.133,-61.3692 410.436,-47.9245 389.183,-37.2217"/>
<polygon fill="grey" stroke="grey" points="390.648,-34.0406 380.142,-32.6687 387.499,-40.2926 390.648,-34.0406"/>
</g>
<!-- 16&#45;&gt;2 -->
<g id="edge10" class="edge"><title>16&#45;&gt;2</title>
<path fill="none" stroke="grey" stroke-width="2" d="M800.573,-1151.7C808.202,-1143.22 817.523,-1132.86 825.876,-1123.58"/>
<polygon fill="grey" stroke="grey" points="828.518,-1125.88 832.606,-1116.1 823.315,-1121.2 828.518,-1125.88"/>
</g>
<!-- 16&#45;&gt;6 -->
<g id="edge22" class="edge"><title>16&#45;&gt;6</title>
<path fill="none" stroke="grey" stroke-width="2" d="M842.674,-1151.97C876.364,-1142.01 919.053,-1129.41 954.329,-1118.99"/>
<polygon fill="grey" stroke="grey" points="955.469,-1122.3 964.068,-1116.11 953.486,-1115.59 955.469,-1122.3"/>
</g>
<!-- 25 -->
<g id="node26" class="node"><title>25</title>
<path fill="none" stroke="#d88556" stroke-width="2" stroke-dasharray="5,2" d="M612,-1116C612,-1116 480,-1116 480,-1116 474,-1116 468,-1110 468,-1104 468,-1104 468,-1092 468,-1092 468,-1086 474,-1080 480,-1080 480,-1080 612,-1080 612,-1080 618,-1080 624,-1086 624,-1092 624,-1092 624,-1104 624,-1104 624,-1110 618,-1116 612,-1116"/>
<text text-anchor="middle" x="546" y="-1095.5" font-family="sans" font-size="10.00">extract_low_coverage_positions</text>
</g>
<!-- 16&#45;&gt;25 -->
<g id="edge56" class="edge"><title>16&#45;&gt;25</title>
<path fill="none" stroke="grey" stroke-width="2" d="M726.84,-1151.97C692.865,-1142.01 649.815,-1129.41 614.243,-1118.99"/>
<polygon fill="grey" stroke="grey" points="615.002,-1115.56 604.421,-1116.11 613.034,-1122.28 615.002,-1115.56"/>
</g>
<!-- 26 -->
<g id="node27" class="node"><title>26</title>
<path fill="none" stroke="#d88556" stroke-width="2" stroke-dasharray="5,2" d="M438,-1116C438,-1116 306,-1116 306,-1116 300,-1116 294,-1110 294,-1104 294,-1104 294,-1092 294,-1092 294,-1086 300,-1080 306,-1080 306,-1080 438,-1080 438,-1080 444,-1080 450,-1086 450,-1092 450,-1092 450,-1104 450,-1104 450,-1110 444,-1116 438,-1116"/>
<text text-anchor="middle" x="372" y="-1095.5" font-family="sans" font-size="10.00">extract_low_coverage_positions</text>
</g>
<!-- 16&#45;&gt;26 -->
<g id="edge58" class="edge"><title>16&#45;&gt;26</title>
<path fill="none" stroke="grey" stroke-width="2" d="M725.714,-1159.94C662.417,-1150.14 558.928,-1133.74 460.089,-1116.17"/>
<polygon fill="grey" stroke="grey" points="460.692,-1112.72 450.233,-1114.41 459.462,-1119.61 460.692,-1112.72"/>
</g>
<!-- 17 -->
<g id="node18" class="node"><title>17</title>
<path fill="none" stroke="#80d856" stroke-width="2" stroke-dasharray="5,2" d="M477,-324C477,-324 369,-324 369,-324 363,-324 357,-318 357,-312 357,-312 357,-300 357,-300 357,-294 363,-288 369,-288 369,-288 477,-288 477,-288 483,-288 489,-294 489,-300 489,-300 489,-312 489,-312 489,-318 483,-324 477,-324"/>
<text text-anchor="middle" x="423" y="-309" font-family="sans" font-size="10.00">split_final_vcf_clonalframe</text>
<text text-anchor="middle" x="423" y="-298" font-family="sans" font-size="10.00">sample: second_isolate</text>
</g>
<!-- 17&#45;&gt;14 -->
<g id="edge36" class="edge"><title>17&#45;&gt;14</title>
<path fill="none" stroke="grey" stroke-width="2" d="M418.056,-287.697C415.828,-279.898 413.145,-270.509 410.665,-261.829"/>
<polygon fill="grey" stroke="grey" points="414,-260.758 407.887,-252.104 407.269,-262.681 414,-260.758"/>
</g>
<!-- 18 -->
<g id="node19" class="node"><title>18</title>
<path fill="none" stroke="#80d856" stroke-width="2" stroke-dasharray="5,2" d="M641,-324C641,-324 533,-324 533,-324 527,-324 521,-318 521,-312 521,-312 521,-300 521,-300 521,-294 527,-288 533,-288 533,-288 641,-288 641,-288 647,-288 653,-294 653,-300 653,-300 653,-312 653,-312 653,-318 647,-324 641,-324"/>
<text text-anchor="middle" x="587" y="-309" font-family="sans" font-size="10.00">split_final_vcf_clonalframe</text>
<text text-anchor="middle" x="587" y="-298" font-family="sans" font-size="10.00">sample: first_isolate</text>
</g>
<!-- 18&#45;&gt;9 -->
<g id="edge25" class="edge"><title>18&#45;&gt;9</title>
<path fill="none" stroke="grey" stroke-width="2" d="M585.764,-287.697C585.213,-279.983 584.551,-270.712 583.937,-262.112"/>
<polygon fill="grey" stroke="grey" points="587.425,-261.83 583.222,-252.104 580.443,-262.328 587.425,-261.83"/>
</g>
<!-- 19&#45;&gt;44 -->
<g id="edge95" class="edge"><title>19&#45;&gt;44</title>
<path fill="none" stroke="grey" stroke-width="2" d="M898.541,-217.737C895.319,-217.147 892.13,-216.566 889,-216 814.508,-202.535 729.706,-187.952 668.134,-177.497"/>
<polygon fill="grey" stroke="grey" points="668.517,-174.012 658.072,-175.791 667.346,-180.914 668.517,-174.012"/>
</g>
<!-- 20&#45;&gt;3 -->
<g id="edge12" class="edge"><title>20&#45;&gt;3</title>
<path fill="none" stroke="grey" stroke-width="2" d="M679.636,-1007.88C656.98,-998.264 628.527,-986.193 604.53,-976.013"/>
<polygon fill="grey" stroke="grey" points="605.805,-972.752 595.232,-972.068 603.071,-979.196 605.805,-972.752"/>
</g>
<!-- 20&#45;&gt;30 -->
<g id="edge61" class="edge"><title>20&#45;&gt;30</title>
<path fill="none" stroke="grey" stroke-width="2" d="M720,-1007.87C720,-983.67 720,-939.211 720,-910.393"/>
<polygon fill="grey" stroke="grey" points="723.5,-910.189 720,-900.189 716.5,-910.189 723.5,-910.189"/>
</g>
<!-- 21 -->
<g id="node22" class="node"><title>21</title>
<path fill="none" stroke="#56d86b" stroke-width="2" stroke-dasharray="5,2" d="M729,-396C729,-396 643,-396 643,-396 637,-396 631,-390 631,-384 631,-384 631,-372 631,-372 631,-366 637,-360 643,-360 643,-360 729,-360 729,-360 735,-360 741,-366 741,-372 741,-372 741,-384 741,-384 741,-390 735,-396 729,-396"/>
<text text-anchor="middle" x="686" y="-375.5" font-family="sans" font-size="10.00">filter_vcf_clonalframe</text>
</g>
<!-- 21&#45;&gt;1 -->
<g id="edge7" class="edge"><title>21&#45;&gt;1</title>
<path fill="none" stroke="grey" stroke-width="2" d="M741.031,-368.125C804.3,-357.846 911.242,-340.24 1003,-324 1015.61,-321.768 1029.19,-319.278 1041.91,-316.907"/>
<polygon fill="grey" stroke="grey" points="1042.71,-320.318 1051.9,-315.038 1041.42,-313.438 1042.71,-320.318"/>
</g>
<!-- 21&#45;&gt;5 -->
<g id="edge20" class="edge"><title>21&#45;&gt;5</title>
<path fill="none" stroke="grey" stroke-width="2" d="M741.216,-361.028C776.304,-350.879 821.994,-337.663 859.403,-326.842"/>
<polygon fill="grey" stroke="grey" points="860.586,-330.144 869.219,-324.003 858.641,-323.419 860.586,-330.144"/>
</g>
<!-- 21&#45;&gt;8 -->
<g id="edge24" class="edge"><title>21&#45;&gt;8</title>
<path fill="none" stroke="grey" stroke-width="2" d="M708.742,-359.697C720.44,-350.796 734.861,-339.823 747.51,-330.199"/>
<polygon fill="grey" stroke="grey" points="749.681,-332.945 755.52,-324.104 745.442,-327.374 749.681,-332.945"/>
</g>
<!-- 21&#45;&gt;17 -->
<g id="edge40" class="edge"><title>21&#45;&gt;17</title>
<path fill="none" stroke="grey" stroke-width="2" d="M630.867,-362.326C592.019,-351.986 539.564,-338.025 497.067,-326.714"/>
<polygon fill="grey" stroke="grey" points="497.893,-323.312 487.329,-324.122 496.092,-330.076 497.893,-323.312"/>
</g>
<!-- 21&#45;&gt;18 -->
<g id="edge41" class="edge"><title>21&#45;&gt;18</title>
<path fill="none" stroke="grey" stroke-width="2" d="M661.782,-359.876C649.077,-350.893 633.336,-339.763 619.577,-330.034"/>
<polygon fill="grey" stroke="grey" points="621.497,-327.105 611.311,-324.19 617.456,-332.821 621.497,-327.105"/>
</g>
<!-- 21&#45;&gt;39 -->
<g id="edge86" class="edge"><title>21&#45;&gt;39</title>
<path fill="none" stroke="grey" stroke-width="2" d="M688.621,-359.828C693.922,-319.705 702.583,-217.633 667,-144 617.463,-41.4902 462.624,-22.5642 390.573,-19.4078"/>
<polygon fill="grey" stroke="grey" points="390.275,-15.8951 380.157,-19.0372 390.026,-22.8907 390.275,-15.8951"/>
</g>
<!-- 22&#45;&gt;3 -->
<g id="edge14" class="edge"><title>22&#45;&gt;3</title>
<path fill="none" stroke="grey" stroke-width="2" d="M677.205,-1080C665.559,-1069.8 650.676,-1056.44 638,-1044 616.687,-1023.08 593.605,-998.129 577.206,-979.975"/>
<polygon fill="grey" stroke="grey" points="579.461,-977.248 570.172,-972.152 574.255,-981.928 579.461,-977.248"/>
</g>
<!-- 22&#45;&gt;12 -->
<g id="edge33" class="edge"><title>22&#45;&gt;12</title>
<path fill="none" stroke="grey" stroke-width="2" d="M660.061,-1079.88C639.51,-1070.35 613.749,-1058.41 591.911,-1048.28"/>
<polygon fill="grey" stroke="grey" points="593.363,-1045.1 582.819,-1044.07 590.419,-1051.45 593.363,-1045.1"/>
</g>
<!-- 22&#45;&gt;13 -->
<g id="edge35" class="edge"><title>22&#45;&gt;13</title>
<path fill="none" stroke="grey" stroke-width="2" d="M641.866,-1082.26C638.869,-1081.49 635.899,-1080.73 633,-1080 573.802,-1065.11 505.479,-1049.03 460.222,-1038.54"/>
<polygon fill="grey" stroke="grey" points="460.895,-1035.1 450.363,-1036.26 459.316,-1041.92 460.895,-1035.1"/>
</g>
<!-- 22&#45;&gt;20 -->
<g id="edge45" class="edge"><title>22&#45;&gt;20</title>
<path fill="none" stroke="grey" stroke-width="2" d="M702.685,-1079.7C705.248,-1071.9 708.333,-1062.51 711.185,-1053.83"/>
<polygon fill="grey" stroke="grey" points="714.584,-1054.7 714.38,-1044.1 707.933,-1052.51 714.584,-1054.7"/>
</g>
<!-- 32 -->
<g id="node33" class="node"><title>32</title>
<path fill="none" stroke="#56d8c1" stroke-width="2" stroke-dasharray="5,2" d="M638.25,-828C638.25,-828 593.75,-828 593.75,-828 587.75,-828 581.75,-822 581.75,-816 581.75,-816 581.75,-804 581.75,-804 581.75,-798 587.75,-792 593.75,-792 593.75,-792 638.25,-792 638.25,-792 644.25,-792 650.25,-798 650.25,-804 650.25,-804 650.25,-816 650.25,-816 650.25,-822 644.25,-828 638.25,-828"/>
<text text-anchor="middle" x="616" y="-807.5" font-family="sans" font-size="10.00">filter_by_AF</text>
</g>
<!-- 22&#45;&gt;32 -->
<g id="edge68" class="edge"><title>22&#45;&gt;32</title>
<path fill="none" stroke="grey" stroke-width="2" d="M687.318,-1079.76C681.924,-1069.6 675.424,-1056.35 671,-1044 645.04,-971.523 627.853,-881.947 620.334,-837.959"/>
<polygon fill="grey" stroke="grey" points="623.777,-837.327 618.672,-828.043 616.874,-838.484 623.777,-837.327"/>
</g>
<!-- 22&#45;&gt;36 -->
<g id="edge75" class="edge"><title>22&#45;&gt;36</title>
<path fill="none" stroke="grey" stroke-width="2" d="M730.025,-1079.88C748.085,-1070.51 770.645,-1058.81 789.951,-1048.8"/>
<polygon fill="grey" stroke="grey" points="791.582,-1051.9 798.848,-1044.19 788.36,-1045.69 791.582,-1051.9"/>
</g>
<!-- 23&#45;&gt;32 -->
<g id="edge66" class="edge"><title>23&#45;&gt;32</title>
<path fill="none" stroke="grey" stroke-width="2" d="M532.909,-863.876C547.158,-854.808 564.846,-843.552 580.236,-833.759"/>
<polygon fill="grey" stroke="grey" points="582.43,-836.511 588.988,-828.19 578.672,-830.606 582.43,-836.511"/>
</g>
<!-- 24&#45;&gt;32 -->
<g id="edge65" class="edge"><title>24&#45;&gt;32</title>
<path fill="none" stroke="grey" stroke-width="2" d="M413.974,-863.966C462.847,-851.152 528.532,-833.932 571.546,-822.655"/>
<polygon fill="grey" stroke="grey" points="572.648,-825.984 581.433,-820.062 570.873,-819.213 572.648,-825.984"/>
</g>
<!-- 25&#45;&gt;12 -->
<g id="edge32" class="edge"><title>25&#45;&gt;12</title>
<path fill="none" stroke="grey" stroke-width="2" d="M546,-1079.7C546,-1071.98 546,-1062.71 546,-1054.11"/>
<polygon fill="grey" stroke="grey" points="549.5,-1054.1 546,-1044.1 542.5,-1054.1 549.5,-1054.1"/>
</g>
<!-- 26&#45;&gt;13 -->
<g id="edge34" class="edge"><title>26&#45;&gt;13</title>
<path fill="none" stroke="grey" stroke-width="2" d="M381.393,-1079.7C385.765,-1071.64 391.057,-1061.89 395.895,-1052.98"/>
<polygon fill="grey" stroke="grey" points="399.02,-1054.56 400.715,-1044.1 392.868,-1051.22 399.02,-1054.56"/>
</g>
<!-- 27 -->
<g id="node28" class="node"><title>27</title>
<path fill="none" stroke="#d6d856" stroke-width="2" stroke-dasharray="5,2" d="M135,-1404C135,-1404 55,-1404 55,-1404 49,-1404 43,-1398 43,-1392 43,-1392 43,-1380 43,-1380 43,-1374 49,-1368 55,-1368 55,-1368 135,-1368 135,-1368 141,-1368 147,-1374 147,-1380 147,-1380 147,-1392 147,-1392 147,-1398 141,-1404 135,-1404"/>
<text text-anchor="middle" x="95" y="-1389" font-family="sans" font-size="10.00">run_snippy</text>
<text text-anchor="middle" x="95" y="-1378" font-family="sans" font-size="10.00">sample: first_isolate</text>
</g>
<!-- 27&#45;&gt;1 -->
<g id="edge5" class="edge"><title>27&#45;&gt;1</title>
<path fill="none" stroke="grey" stroke-width="2" d="M83.1896,-1367.96C66.4939,-1342.16 38,-1291.08 38,-1243 38,-1243 38,-1243 38,-953 38,-743.489 143.001,-686.504 321,-576 359.008,-552.404 376.432,-562.669 415,-540 436.488,-527.37 436.111,-515.921 458,-504 562.378,-447.154 909.46,-354.516 1041.97,-320.271"/>
<polygon fill="grey" stroke="grey" points="1043.07,-323.601 1051.88,-317.715 1041.32,-316.823 1043.07,-323.601"/>
</g>
<!-- 27&#45;&gt;4 -->
<g id="edge17" class="edge"><title>27&#45;&gt;4</title>
<path fill="none" stroke="grey" stroke-width="2" d="M147.165,-1378.46C173.49,-1375.21 205.927,-1371.29 235,-1368 405.578,-1348.71 608.791,-1328.16 696.775,-1319.38"/>
<polygon fill="grey" stroke="grey" points="697.32,-1322.85 706.924,-1318.37 696.626,-1315.88 697.32,-1322.85"/>
</g>
<!-- 27&#45;&gt;9 -->
<g id="edge26" class="edge"><title>27&#45;&gt;9</title>
<path fill="none" stroke="grey" stroke-width="2" d="M73.443,-1367.78C45.414,-1343.28 0,-1295.5 0,-1243 0,-1243 0,-1243 0,-953 0,-741.034 343.136,-291.529 348,-288 354.111,-283.567 428.363,-267.154 491.609,-253.753"/>
<polygon fill="grey" stroke="grey" points="492.593,-257.123 501.653,-251.631 491.146,-250.274 492.593,-257.123"/>
</g>
<!-- 27&#45;&gt;24 -->
<g id="edge53" class="edge"><title>27&#45;&gt;24</title>
<path fill="none" stroke="grey" stroke-width="2" d="M106.81,-1367.96C123.506,-1342.16 152,-1291.08 152,-1243 152,-1243 152,-1243 152,-1025 152,-961.83 219.483,-923.962 275.456,-903.417"/>
<polygon fill="grey" stroke="grey" points="276.781,-906.661 285.04,-900.024 274.445,-900.062 276.781,-906.661"/>
</g>
<!-- 27&#45;&gt;26 -->
<g id="edge57" class="edge"><title>27&#45;&gt;26</title>
<path fill="none" stroke="grey" stroke-width="2" d="M120.635,-1367.8C134.594,-1357.96 151.854,-1345.02 166,-1332 241.201,-1262.78 317.826,-1168.53 352.649,-1124.11"/>
<polygon fill="grey" stroke="grey" points="355.457,-1126.2 358.85,-1116.17 349.939,-1121.9 355.457,-1126.2"/>
</g>
<!-- 34 -->
<g id="node35" class="node"><title>34</title>
<path fill="none" stroke="#569ad8" stroke-width="2" stroke-dasharray="5,2" d="M387,-684C387,-684 305,-684 305,-684 299,-684 293,-678 293,-672 293,-672 293,-660 293,-660 293,-654 299,-648 305,-648 305,-648 387,-648 387,-648 393,-648 399,-654 399,-660 399,-660 399,-672 399,-672 399,-678 393,-684 387,-684"/>
<text text-anchor="middle" x="346" y="-663.5" font-family="sans" font-size="10.00">create_fasta_for_vcf</text>
</g>
<!-- 27&#45;&gt;34 -->
<g id="edge71" class="edge"><title>27&#45;&gt;34</title>
<path fill="none" stroke="grey" stroke-width="2" d="M96.9264,-1367.94C101.757,-1323.64 114,-1201.26 114,-1099 114,-1099 114,-1099 114,-1025 114,-874.522 160.518,-832.014 261,-720 271.86,-707.894 286.128,-697.56 299.865,-689.319"/>
<polygon fill="grey" stroke="grey" points="301.842,-692.22 308.775,-684.209 298.359,-686.148 301.842,-692.22"/>
</g>
<!-- 28 -->
<g id="node29" class="node"><title>28</title>
<path fill="none" stroke="#d6d856" stroke-width="2" stroke-dasharray="5,2" d="M351.25,-1404C351.25,-1404 256.75,-1404 256.75,-1404 250.75,-1404 244.75,-1398 244.75,-1392 244.75,-1392 244.75,-1380 244.75,-1380 244.75,-1374 250.75,-1368 256.75,-1368 256.75,-1368 351.25,-1368 351.25,-1368 357.25,-1368 363.25,-1374 363.25,-1380 363.25,-1380 363.25,-1392 363.25,-1392 363.25,-1398 357.25,-1404 351.25,-1404"/>
<text text-anchor="middle" x="304" y="-1389" font-family="sans" font-size="10.00">run_snippy</text>
<text text-anchor="middle" x="304" y="-1378" font-family="sans" font-size="10.00">sample: second_isolate</text>
</g>
<!-- 28&#45;&gt;1 -->
<g id="edge8" class="edge"><title>28&#45;&gt;1</title>
<path fill="none" stroke="grey" stroke-width="2" d="M303.017,-1367.74C300.967,-1337.89 295.104,-1274.94 280,-1224 252.635,-1131.71 190,-1123.26 190,-1027 190,-1027 190,-1027 190,-809 190,-726.141 224.656,-705.826 284,-648 540.987,-397.587 776.161,-626.679 1051,-396 1070.03,-380.029 1081.29,-353.661 1087.48,-333.761"/>
<polygon fill="grey" stroke="grey" points="1090.87,-334.611 1090.27,-324.034 1084.15,-332.681 1090.87,-334.611"/>
</g>
<!-- 28&#45;&gt;4 -->
<g id="edge18" class="edge"><title>28&#45;&gt;4</title>
<path fill="none" stroke="grey" stroke-width="2" d="M363.391,-1375.49C452.28,-1361.25 617.9,-1334.72 696.889,-1322.07"/>
<polygon fill="grey" stroke="grey" points="697.669,-1325.49 706.989,-1320.45 696.562,-1318.57 697.669,-1325.49"/>
</g>
<!-- 28&#45;&gt;14 -->
<g id="edge37" class="edge"><title>28&#45;&gt;14</title>
<path fill="none" stroke="grey" stroke-width="2" d="M282.55,-1367.78C225.793,-1320.14 76,-1179.9 76,-1027 76,-1027 76,-1027 76,-953 76,-824.772 38,-795.228 38,-667 38,-667 38,-667 38,-377 38,-318.234 204.407,-274.088 312.501,-251.611"/>
<polygon fill="grey" stroke="grey" points="313.355,-255.008 322.447,-249.569 311.948,-248.151 313.355,-255.008"/>
</g>
<!-- 28&#45;&gt;23 -->
<g id="edge50" class="edge"><title>28&#45;&gt;23</title>
<path fill="none" stroke="grey" stroke-width="2" d="M297.766,-1367.89C281.383,-1320.03 241.292,-1181.62 285,-1080 320.421,-997.65 410.157,-936.07 463.758,-905.182"/>
<polygon fill="grey" stroke="grey" points="465.702,-908.103 472.68,-900.131 462.254,-902.012 465.702,-908.103"/>
</g>
<!-- 28&#45;&gt;25 -->
<g id="edge55" class="edge"><title>28&#45;&gt;25</title>
<path fill="none" stroke="grey" stroke-width="2" d="M321.748,-1367.72C331.997,-1357.55 344.997,-1344.3 356,-1332 421.426,-1258.89 493.208,-1167.53 526.739,-1124.13"/>
<polygon fill="grey" stroke="grey" points="529.588,-1126.17 532.922,-1116.11 524.044,-1121.89 529.588,-1126.17"/>
</g>
<!-- 33 -->
<g id="node34" class="node"><title>33</title>
<path fill="none" stroke="#569ad8" stroke-width="2" stroke-dasharray="5,2" d="M514,-684C514,-684 432,-684 432,-684 426,-684 420,-678 420,-672 420,-672 420,-660 420,-660 420,-654 426,-648 432,-648 432,-648 514,-648 514,-648 520,-648 526,-654 526,-660 526,-660 526,-672 526,-672 526,-678 520,-684 514,-684"/>
<text text-anchor="middle" x="473" y="-663.5" font-family="sans" font-size="10.00">create_fasta_for_vcf</text>
</g>
<!-- 28&#45;&gt;33 -->
<g id="edge69" class="edge"><title>28&#45;&gt;33</title>
<path fill="none" stroke="grey" stroke-width="2" d="M287.509,-1367.77C265.157,-1342.53 228,-1293.05 228,-1243 228,-1243 228,-1243 228,-1025 228,-956.049 238.488,-770.9 285,-720 287.221,-717.57 355.962,-698.576 409.681,-684.014"/>
<polygon fill="grey" stroke="grey" points="410.779,-687.342 419.517,-681.351 408.95,-680.586 410.779,-687.342"/>
</g>
<!-- 29&#45;&gt;21 -->
<g id="edge47" class="edge"><title>29&#45;&gt;21</title>
<path fill="none" stroke="grey" stroke-width="2" d="M459.527,-437.284C503.763,-425.899 571.37,-408.5 621.208,-395.675"/>
<polygon fill="grey" stroke="grey" points="622.114,-399.055 630.926,-393.173 620.369,-392.276 622.114,-399.055"/>
</g>
<!-- 29&#45;&gt;39 -->
<g id="edge81" class="edge"><title>29&#45;&gt;39</title>
<path fill="none" stroke="grey" stroke-width="2" d="M384.951,-431.912C349.437,-408.579 294,-363.162 294,-307 294,-307 294,-307 294,-161 294,-117.827 317.545,-72.5334 334.887,-45.0268"/>
<polygon fill="grey" stroke="grey" points="337.973,-46.7013 340.488,-36.4092 332.104,-42.8868 337.973,-46.7013"/>
</g>
<!-- 30&#45;&gt;32 -->
<g id="edge64" class="edge"><title>30&#45;&gt;32</title>
<path fill="none" stroke="grey" stroke-width="2" d="M694.559,-863.876C681.213,-854.893 664.676,-843.763 650.222,-834.034"/>
<polygon fill="grey" stroke="grey" points="651.789,-830.87 641.539,-828.19 647.881,-836.677 651.789,-830.87"/>
</g>
<!-- 31 -->
<g id="node32" class="node"><title>31</title>
<path fill="none" stroke="#d6d856" stroke-width="2" stroke-dasharray="5,2" d="M1188.25,-1404C1188.25,-1404 1105.75,-1404 1105.75,-1404 1099.75,-1404 1093.75,-1398 1093.75,-1392 1093.75,-1392 1093.75,-1380 1093.75,-1380 1093.75,-1374 1099.75,-1368 1105.75,-1368 1105.75,-1368 1188.25,-1368 1188.25,-1368 1194.25,-1368 1200.25,-1374 1200.25,-1380 1200.25,-1380 1200.25,-1392 1200.25,-1392 1200.25,-1398 1194.25,-1404 1188.25,-1404"/>
<text text-anchor="middle" x="1147" y="-1389" font-family="sans" font-size="10.00">run_snippy</text>
<text text-anchor="middle" x="1147" y="-1378" font-family="sans" font-size="10.00">sample: third_isolate</text>
</g>
<!-- 31&#45;&gt;1 -->
<g id="edge6" class="edge"><title>31&#45;&gt;1</title>
<path fill="none" stroke="grey" stroke-width="2" d="M1175.67,-1367.9C1189.65,-1358.55 1206,-1346.03 1218,-1332 1291.25,-1246.36 1318,-1211.69 1318,-1099 1318,-1099 1318,-1099 1318,-809 1318,-610.453 1170.06,-403.076 1114.64,-332.347"/>
<polygon fill="grey" stroke="grey" points="1117.3,-330.077 1108.35,-324.409 1111.82,-334.422 1117.3,-330.077"/>
</g>
<!-- 31&#45;&gt;2 -->
<g id="edge9" class="edge"><title>31&#45;&gt;2</title>
<path fill="none" stroke="grey" stroke-width="2" d="M1129.19,-1367.97C1078.42,-1319.4 932.784,-1180.1 873.535,-1123.42"/>
<polygon fill="grey" stroke="grey" points="875.739,-1120.69 866.093,-1116.31 870.9,-1125.75 875.739,-1120.69"/>
</g>
<!-- 31&#45;&gt;4 -->
<g id="edge19" class="edge"><title>31&#45;&gt;4</title>
<path fill="none" stroke="grey" stroke-width="2" d="M1093.51,-1375.78C1012.48,-1361.81 860.142,-1335.54 785.084,-1322.6"/>
<polygon fill="grey" stroke="grey" points="785.471,-1319.12 775.022,-1320.87 784.282,-1326.01 785.471,-1319.12"/>
</g>
<!-- 31&#45;&gt;30 -->
<g id="edge62" class="edge"><title>31&#45;&gt;30</title>
<path fill="none" stroke="grey" stroke-width="2" d="M1143.16,-1367.61C1137.6,-1340.94 1128,-1288.27 1128,-1243 1128,-1243 1128,-1243 1128,-1025 1128,-990.44 916.497,-932.034 798.052,-902.036"/>
<polygon fill="grey" stroke="grey" points="798.842,-898.626 788.29,-899.575 797.131,-905.414 798.842,-898.626"/>
</g>
<!-- 38 -->
<g id="node39" class="node"><title>38</title>
<path fill="none" stroke="#569ad8" stroke-width="2" stroke-dasharray="5,2" d="M648,-684C648,-684 566,-684 566,-684 560,-684 554,-678 554,-672 554,-672 554,-660 554,-660 554,-654 560,-648 566,-648 566,-648 648,-648 648,-648 654,-648 660,-654 660,-660 660,-660 660,-672 660,-672 660,-678 654,-684 648,-684"/>
<text text-anchor="middle" x="607" y="-663.5" font-family="sans" font-size="10.00">create_fasta_for_vcf</text>
</g>
<!-- 31&#45;&gt;38 -->
<g id="edge77" class="edge"><title>31&#45;&gt;38</title>
<path fill="none" stroke="grey" stroke-width="2" d="M1152.89,-1367.83C1167.45,-1323.75 1204,-1202.79 1204,-1099 1204,-1099 1204,-1099 1204,-809 1204,-781.809 824.217,-707.659 670.474,-678.756"/>
<polygon fill="grey" stroke="grey" points="670.716,-675.24 660.242,-676.836 669.425,-682.12 670.716,-675.24"/>
</g>
<!-- 31&#45;&gt;46 -->
<g id="edge98" class="edge"><title>31&#45;&gt;46</title>
<path fill="none" stroke="grey" stroke-width="2" d="M1160.68,-1367.63C1168.06,-1357.64 1176.87,-1344.61 1183,-1332 1245.17,-1204.06 1280,-1169.25 1280,-1027 1280,-1027 1280,-1027 1280,-809 1280,-677.876 1105.88,-369.299 1003,-288 993.388,-280.404 937.818,-266.155 887.246,-254.343"/>
<polygon fill="grey" stroke="grey" points="887.746,-250.866 877.214,-252.016 886.164,-257.685 887.746,-250.866"/>
</g>
<!-- 32&#45;&gt;1 -->
<g id="edge3" class="edge"><title>32&#45;&gt;1</title>
<path fill="none" stroke="grey" stroke-width="2" d="M650.553,-806.633C763.262,-797.977 1113,-763.356 1113,-667 1113,-667 1113,-667 1113,-449 1113,-408.86 1105.45,-362.897 1099.87,-334.405"/>
<polygon fill="grey" stroke="grey" points="1103.26,-333.498 1097.84,-324.388 1096.39,-334.883 1103.26,-333.498"/>
</g>
<!-- 32&#45;&gt;21 -->
<g id="edge46" class="edge"><title>32&#45;&gt;21</title>
<path fill="none" stroke="grey" stroke-width="2" d="M638.337,-791.836C649.151,-782.388 661.407,-769.793 669,-756 688.551,-720.484 689,-707.542 689,-667 689,-667 689,-667 689,-521 689,-480.987 687.795,-434.646 686.912,-406.076"/>
<polygon fill="grey" stroke="grey" points="690.409,-405.93 686.593,-396.047 683.413,-406.153 690.409,-405.93"/>
</g>
<!-- 35 -->
<g id="node36" class="node"><title>35</title>
<path fill="none" stroke="#56d8d8" stroke-width="2" stroke-dasharray="5,2" d="M648.25,-756C648.25,-756 565.75,-756 565.75,-756 559.75,-756 553.75,-750 553.75,-744 553.75,-744 553.75,-732 553.75,-732 553.75,-726 559.75,-720 565.75,-720 565.75,-720 648.25,-720 648.25,-720 654.25,-720 660.25,-726 660.25,-732 660.25,-732 660.25,-744 660.25,-744 660.25,-750 654.25,-756 648.25,-756"/>
<text text-anchor="middle" x="607" y="-741" font-family="sans" font-size="10.00">split_final_vcf</text>
<text text-anchor="middle" x="607" y="-730" font-family="sans" font-size="10.00">sample: third_isolate</text>
</g>
<!-- 32&#45;&gt;35 -->
<g id="edge73" class="edge"><title>32&#45;&gt;35</title>
<path fill="none" stroke="grey" stroke-width="2" d="M613.775,-791.697C612.783,-783.983 611.592,-774.712 610.486,-766.112"/>
<polygon fill="grey" stroke="grey" points="613.946,-765.576 609.199,-756.104 607.003,-766.469 613.946,-765.576"/>
</g>
<!-- 37 -->
<g id="node38" class="node"><title>37</title>
<path fill="none" stroke="#56d8d8" stroke-width="2" stroke-dasharray="5,2" d="M818.25,-756C818.25,-756 729.75,-756 729.75,-756 723.75,-756 717.75,-750 717.75,-744 717.75,-744 717.75,-732 717.75,-732 717.75,-726 723.75,-720 729.75,-720 729.75,-720 818.25,-720 818.25,-720 824.25,-720 830.25,-726 830.25,-732 830.25,-732 830.25,-744 830.25,-744 830.25,-750 824.25,-756 818.25,-756"/>
<text text-anchor="middle" x="774" y="-741" font-family="sans" font-size="10.00">split_final_vcf</text>
<text text-anchor="middle" x="774" y="-730" font-family="sans" font-size="10.00">sample: fourth_isolate</text>
</g>
<!-- 32&#45;&gt;37 -->
<g id="edge76" class="edge"><title>32&#45;&gt;37</title>
<path fill="none" stroke="grey" stroke-width="2" d="M650.284,-793.811C672.478,-783.978 701.693,-771.035 726.16,-760.195"/>
<polygon fill="grey" stroke="grey" points="727.9,-763.252 735.625,-756.002 725.064,-756.852 727.9,-763.252"/>
</g>
<!-- 32&#45;&gt;39 -->
<g id="edge83" class="edge"><title>32&#45;&gt;39</title>
<path fill="none" stroke="grey" stroke-width="2" d="M581.561,-808.993C451.835,-807.003 0,-781.515 0,-523 0,-523 0,-523 0,-161 0,-93.4186 225.51,-43.1541 316.042,-25.6983"/>
<polygon fill="grey" stroke="grey" points="316.716,-29.1329 325.887,-23.8272 315.409,-22.256 316.716,-29.1329"/>
</g>
<!-- 40 -->
<g id="node41" class="node"><title>40</title>
<path fill="none" stroke="#56d8d8" stroke-width="2" stroke-dasharray="5,2" d="M386,-756C386,-756 306,-756 306,-756 300,-756 294,-750 294,-744 294,-744 294,-732 294,-732 294,-726 300,-720 306,-720 306,-720 386,-720 386,-720 392,-720 398,-726 398,-732 398,-732 398,-744 398,-744 398,-750 392,-756 386,-756"/>
<text text-anchor="middle" x="346" y="-741" font-family="sans" font-size="10.00">split_final_vcf</text>
<text text-anchor="middle" x="346" y="-730" font-family="sans" font-size="10.00">sample: first_isolate</text>
</g>
<!-- 32&#45;&gt;40 -->
<g id="edge87" class="edge"><title>32&#45;&gt;40</title>
<path fill="none" stroke="grey" stroke-width="2" d="M581.542,-800.525C542.004,-790.742 474.975,-773.981 408.086,-756.261"/>
<polygon fill="grey" stroke="grey" points="408.785,-752.825 398.221,-753.64 406.987,-759.591 408.785,-752.825"/>
</g>
<!-- 41 -->
<g id="node42" class="node"><title>41</title>
<path fill="none" stroke="#56d8d8" stroke-width="2" stroke-dasharray="5,2" d="M523.25,-756C523.25,-756 428.75,-756 428.75,-756 422.75,-756 416.75,-750 416.75,-744 416.75,-744 416.75,-732 416.75,-732 416.75,-726 422.75,-720 428.75,-720 428.75,-720 523.25,-720 523.25,-720 529.25,-720 535.25,-726 535.25,-732 535.25,-732 535.25,-744 535.25,-744 535.25,-750 529.25,-756 523.25,-756"/>
<text text-anchor="middle" x="476" y="-741" font-family="sans" font-size="10.00">split_final_vcf</text>
<text text-anchor="middle" x="476" y="-730" font-family="sans" font-size="10.00">sample: second_isolate</text>
</g>
<!-- 32&#45;&gt;41 -->
<g id="edge88" class="edge"><title>32&#45;&gt;41</title>
<path fill="none" stroke="grey" stroke-width="2" d="M581.752,-791.876C562.939,-782.469 539.415,-770.708 519.334,-760.667"/>
<polygon fill="grey" stroke="grey" points="520.889,-757.531 510.38,-756.19 517.759,-763.792 520.889,-757.531"/>
</g>
<!-- 33&#45;&gt;11 -->
<g id="edge28" class="edge"><title>33&#45;&gt;11</title>
<path fill="none" stroke="grey" stroke-width="2" d="M473,-647.697C473,-639.983 473,-630.712 473,-622.112"/>
<polygon fill="grey" stroke="grey" points="476.5,-622.104 473,-612.104 469.5,-622.104 476.5,-622.104"/>
</g>
<!-- 34&#45;&gt;11 -->
<g id="edge29" class="edge"><title>34&#45;&gt;11</title>
<path fill="none" stroke="grey" stroke-width="2" d="M377.068,-647.876C393.827,-638.639 414.706,-627.131 432.702,-617.212"/>
<polygon fill="grey" stroke="grey" points="434.745,-620.082 441.813,-612.19 431.366,-613.952 434.745,-620.082"/>
</g>
<!-- 35&#45;&gt;38 -->
<g id="edge78" class="edge"><title>35&#45;&gt;38</title>
<path fill="none" stroke="grey" stroke-width="2" d="M607,-719.697C607,-711.983 607,-702.712 607,-694.112"/>
<polygon fill="grey" stroke="grey" points="610.5,-694.104 607,-684.104 603.5,-694.104 610.5,-694.104"/>
</g>
<!-- 36&#45;&gt;3 -->
<g id="edge13" class="edge"><title>36&#45;&gt;3</title>
<path fill="none" stroke="grey" stroke-width="2" d="M791.703,-1013.99C784.165,-1011.97 776.348,-1009.9 769,-1008 724.155,-996.398 673.885,-983.92 633.341,-973.989"/>
<polygon fill="grey" stroke="grey" points="634.064,-970.562 623.519,-971.586 632.401,-977.362 634.064,-970.562"/>
</g>
<!-- 36&#45;&gt;47 -->
<g id="edge100" class="edge"><title>36&#45;&gt;47</title>
<path fill="none" stroke="grey" stroke-width="2" d="M837.066,-1007.87C844.256,-983.564 857.49,-938.819 866.01,-910.013"/>
<polygon fill="grey" stroke="grey" points="869.436,-910.771 868.916,-900.189 862.723,-908.786 869.436,-910.771"/>
</g>
<!-- 42 -->
<g id="node43" class="node"><title>42</title>
<path fill="none" stroke="#569ad8" stroke-width="2" stroke-dasharray="5,2" d="M815,-684C815,-684 733,-684 733,-684 727,-684 721,-678 721,-672 721,-672 721,-660 721,-660 721,-654 727,-648 733,-648 733,-648 815,-648 815,-648 821,-648 827,-654 827,-660 827,-660 827,-672 827,-672 827,-678 821,-684 815,-684"/>
<text text-anchor="middle" x="774" y="-663.5" font-family="sans" font-size="10.00">create_fasta_for_vcf</text>
</g>
<!-- 37&#45;&gt;42 -->
<g id="edge90" class="edge"><title>37&#45;&gt;42</title>
<path fill="none" stroke="grey" stroke-width="2" d="M774,-719.697C774,-711.983 774,-702.712 774,-694.112"/>
<polygon fill="grey" stroke="grey" points="777.5,-694.104 774,-684.104 770.5,-694.104 777.5,-694.104"/>
</g>
<!-- 38&#45;&gt;11 -->
<g id="edge30" class="edge"><title>38&#45;&gt;11</title>
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<text text-anchor="middle" x="1318" y="-1389" font-family="sans" font-size="10.00">run_snippy</text>
<text text-anchor="middle" x="1318" y="-1378" font-family="sans" font-size="10.00">sample: fourth_isolate</text>
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<!-- 45&#45;&gt;47 -->
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<!-- 46&#45;&gt;44 -->
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