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README.html
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README.html
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<html><pre>
This is the readme for the model published in
Kampa & Stuart (2006) Calcium spikes in basal dendrites of layer 5
pyramidal neurons during action potential bursts.
J Neurosci 26(28):7424-32.
The simulation creates two plots showing voltage and calcium changes
in basal dendrites of layer 5 pyramidal neurons during action
potential (AP) backpropagation. Running after selecting 1 AP leads
to (after zooming in on the Ca2+ plot):
<img src="./screenshot.jpg" alt="screenshot">
Usage:
Autolaunch from ModelDB **or** download and extract the archive and
then compile the mod files in the mod directory and run under ...
linux/unix
----------
by typing
nrnivmodl mod
in the top level directory. Then type
nrngui mosinit.hoc
mswin
-------
by running mknrndll, cd'ing to the mod directory and press make
nrnmech.dll button. Copy the nrnmech.dll file to the parent directory
of the mod folder (the top-level directory). Double click on the
mosinit.hoc file.
MAC OS X
--------
drag and drop the mod folder onto mknrndll icon in the NEURON
application folder. Start a terminal window, cd to the directory
within the expanded archive and type
mod/powerpc/special mosinit.hoc -
to start the simulation.
-------
Choose the number of APs in a burst and press the run button. By
increasing the number of APs the calcium signal in the basal dendrites
will increase supralinearly. 3 or more APs in a burst will lead to
generation of a dendritic calcium spike similar to the experimental
results shown in Kampa & Stuart (2006).
In addition, a 4-AP experiment, blocking IA channels, can be simulated
or a TTX experiment blocking local Na channels.
created by B. Kampa (2006)
kampa@hifo.uzh.ch
20120126 Cad.mod solve method updated to derivimplicit from euler as per
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592
</pre></html>