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Golgi_ComPanel.hoc
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Golgi_ComPanel.hoc
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/*******Cerebellar Golgi Cell Model **********
Developers: Sergio Solinas & Egidio D'Angelo
Code contributors: Thierry Neius, Shyam Diwakar, Lia Forti
Data Analysis: Sergio Solinas
Work Progress: April 2004 - May 2007
Developed At: Università Degli Studi Di Pavia
Dipartimento Di Scienze Fisiologiche
Pavia - Italia
Model Published in:
Sergio M. Solinas, Lia Forti, Elisabetta Cesana,
Jonathan Mapelli, Erik De Schutter and Egidio D`Angelo (2008)
Computational reconstruction of pacemaking and intrinsic
electroresponsiveness in cerebellar golgi cells
Frontiers in Cellular Neuroscience 2:2
********************************************/
objref AmpaSchemeMenu,mfpanel
objref Golgi_params
xpanel("Comand Panel",0)
xmenu()
xbutton("Golgi Cell","Golgi_Panel()")
xbutton("Channels","Golgi_Channels()")
xbutton("Synapses","Postsyn_conf()")
xbutton("Intrisic noise","Gnoise()")
xbutton("Firing statistics","FR_show()") // FR_show is in utils.hoc
xmenu()
xpanel(1090,25,0)
proc Golgi_Panel(){
lkg_erev = Golgi[0].soma.el_Golgi_lkg
lkg_gbar = Golgi[0].soma.glbar_Golgi_lkg
na_gbar = Golgi[0].soma.gnabar_Golgi_Na
Golgi_params = new VBox()
Golgi_params.intercept(1)
xpanel("1")
xlabel("Conductances")
xvalue("gNabar","Golgi[0].soma.gnabar_Golgi_Na", 1,"", 0, 0 )
xvalue("gNapbar","Golgi[0].soma.gbar_Golgi_NaP", 1,"", 0, 0 )
xvalue("gNaresurgent","Golgi[0].soma.gnabar_Golgi_NaR", 1,"", 0, 0 )
xvalue("gKVbar","Golgi[0].soma.gkbar_Golgi_KV", 1,"", 0, 0 )
xvalue("gKAbar","Golgi[0].soma.gkbar_Golgi_KA", 1,"", 0, 0 )
xvalue("gKCabar","Golgi[0].soma.gkbar_Golgi_BK", 1,"", 0, 0 )
xvalue("gCaHVAbar","Golgi[0].soma.gcabar_Golgi_Ca_HVA", 1,"", 0, 0 )
xvalue("gCaLVAbar","Golgi[0].soma.gca2bar_Golgi_Ca_LVA", 1,"", 0, 0 )
xvalue("gKSlowbar","Golgi[0].soma.gkbar_Golgi_KM", 1,"", 0, 0 )
xvalue("gSK2bar","Golgi[0].soma.gkbar_Golgi_SK2", 1,"", 0, 0 )
xvalue("ghcn1bar","Golgi[0].soma.gbar_Golgi_hcn1", 1,"", 0, 0 )
xvalue("ghcn2bar","Golgi[0].soma.gbar_Golgi_hcn2", 1,"", 0, 0 )
xvalue("Lkg Erev (mV)","lkg_erev", 1,"UpDatelkg()", 0, 0 )
xvalue("Lkg gbar (S/cm2)","lkg_gbar", 1,"UpDatelkg()", 0, 0 )
xlabel("Passive properties: ")
strdef stroutput
sprint(stroutput,"K: Erev %3.0f (mV)",Golgi[0].soma.ek)
xlabel(stroutput)
sprint(stroutput,"Na: Erev %3.0f (mV)",Golgi[0].soma.ena)
xlabel(stroutput)
sprint(stroutput,"Ca: Erev %3.0f (mV)",Golgi[0].soma.eca)
sprint(stroutput,"Cai %5.0f (nM) Cao %3.0f (mM)",Golgi[0].soma.cai*1e6,Golgi[0].soma.cao)
xlabel(stroutput)
sprint(stroutput,"Rm %4.0f (MOhm)",1e-6/(Golgi[0].soma.glbar_Golgi_lkg*cell_surf_cm))
xlabel(stroutput)
sprint(stroutput,"Cm %5.1f (pF)",Golgi[0].soma.cm*cell_surf_cm*1e6)
xlabel(stroutput)
xpanel()
xpanel("2")
xlabel("Calcium HVA parameters")
xvalue("Shell thickness","Golgi[0].soma.d_Golgi_CALC", 1,"", 0, 0 )
xvalue("Initial concentration","Golgi[0].soma.cai0_Golgi_CALC", 1,"", 0, 0 )
xvalue("Removal rate","Golgi[0].soma.beta_Golgi_CALC", 1,"", 0, 0 )
xlabel("Calcium LVA parameters")
xvalue("Shell thickness","Golgi[0].soma.d_Golgi_CALC_ca2", 1,"", 0, 0 )
xvalue("Initial concentration","Golgi[0].soma.ca2i0_Golgi_CALC_ca2", 1,"", 0, 0 )
xvalue("Removal rate","Golgi[0].soma.beta_Golgi_CALC_ca2", 1,"", 0, 0 )
xpanel()
Golgi_params.intercept(0)
Golgi_params.map("Golgi Cell Parameters", 1352, 22, 309, 742)
}
proc Golgi_Channels() {
xopen("Channel_dynamics.hoc")
}
proc Postsyn_conf() {
xpanel("Synaptic paramters")
xstatebutton("Activate synapses",&synstate ,"set_syn_start(synstate)")
xlabel ("Excitatory synapses: 26 per dendrite")
exc_gmax = Golgi[0].exc[0].gmax
xvalue ("Max cond. (pS)","exc_gmax", 1,"set_exc_gmax(exc_gmax)", 0, 0 )
xvalue ("Stim. freq. (Hz)","Exc_freq",1,"Set_Exc_freq(Exc_freq)", 0, 0 )
xlabel ("Inhibitory synapses: 13 per dendrite")
inh_gmax = Golgi[0].inh[0].gmax
xvalue ("Max cond. (pS)","inh_gmax", 1,"set_inh_gmax(inh_gmax)", 0, 0 )
xvalue ("Stim. freq. (Hz)","Inh_freq",1,"Set_Inh_freq(Inh_freq)", 0, 0 )
xpanel()
}
proc set_syn_start(){local syn_start
syn_start = (!$1)*1e9
for i=0,77 {
Exc[i].start = syn_start
}
for i=0,26 {
Inh[i].start = syn_start
}
}
proc set_exc_gmax(){
for i=0,77 {Golgi[0].exc[i].gmax = $1}
}
proc set_inh_gmax(){
for i=0,26 {Golgi[0].inh[i].gmax = $1}
}
proc Set_Exc_freq() {
for i=0,77 {
Exc[i].fast_invl = 1000/$1
}
}
proc Set_Inh_freq(){
for i=0,26 {
Inh[i].fast_invl = 1000/$1
}
}
proc Gnoise() {
xpanel("Intirsic noise")
xstatebutton("Activate",&gnoisestate ,"set_gnoise_start(gnoisestate,gnoise)")
xvalue("Amplitude (nA)","gauss_noise_amp", 1,"r.normal(0,gauss_noise_amp)", 0, 0 )
xpanel()
}
proc set_gnoise_start() {
$o2.del = (!$1)*1e9
$o2.dur = 100000
$o2.amp = ($1)*1e9
cvode.active(!$1)
}
strdef dirn
strdef KinMenu
KinMenu="kinetics.hoc"
objref Golgi_params
proc UpDatelkg() {
Golgi[0].soma.el_Golgi_lkg = lkg_erev
for i=0,2 Golgi[0].dend[i].el_Golgi_lkg = lkg_erev
Golgi[0].axon.el_Golgi_lkg = lkg_erev
Golgi[0].soma.glbar_Golgi_lkg = lkg_gbar
for i=0,2 Golgi[0].dend[i].glbar_Golgi_lkg = lkg_gbar
Golgi[0].axon.glbar_Golgi_lkg = lkg_gbar
}