SmallMolecule <treats, disrupts, prevents, affects> PhenotypicFeature (HP:0011015 Abnormal blood glucose concentration))

[sstemann]

Query: Blood_Glucose_Concen.json
PK: 2ac4824e-a783-4633-85a7-f4188020d240

[colleenXu]

This looks like a "Disease vs PhenotypicFeature" thing. Also an HP -> UMLS issue.

If one uses a "Disease" hyperglycemia ID (MONDO:0002909), one gets back results from every ARA (I didn't wait for Aragorn to finish loading when I took the screenshot, but I assume it has a large response). This MONDO ID is mapped by Node Normalizer to UMLS:C0020456 which has assertions in semmeddb.

https://arax.ncats.io/?r=f32fa057-2085-4896-bc75-fa8e1cec0188

In comparison, the HP ID used in the original query is mapped by Node Normalizer to UMLS:C4023597, which doesn't seem to have any assertions in semmeddb.

---

disease query

{
    "message": {
        "query_graph": {
            "edges": {
                "e00": {
                    "subject": "n01",
                    "object": "n00",
                    "predicates": [
                        "biolink:treats",
                        "biolink:disrupts",
                        "biolink:prevents",
                        "biolink:affects"
                    ]
                }
            },
            "nodes": {
                "n00": {
                    "ids": [
                        "MONDO:0002909"
                    ],
                    "categories": [
                        "biolink:Disease"
                    ]
                },
                "n01": {
                    "categories": [
                        "biolink:SmallMolecule"
                    ]
                }
            }
        }
    }
}

[sstemann]

https://ui.ci.transltr.io/main/results?l=Abnormal%20Blood%20Glucose%20Concentration&i=HP:0011015&t=0&q=313574d3-8d3b-446c-97e2-132d1b918bfb