Daraprim Synthesis

[vchioti]

Ann-Victoria Isaac and I, Vasiliki Theologia Chioti, are going to work on the synthesis of 5-(4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine, which is traded as Daraprim. The reaction scheme we will follow is attached below. Use the following link to access our electronic lab notebook and monitor the progress of our research: http://malaria.ourexperiment.org/daraprim_malaria

ClC2=CC=C(C(C(N)=NC(N)=N3)=C3CC)C=C2

[MFernflower]

Love the idea of using polymer supported dimethylsulfate!!!!

[holeung]

What's the point of this?

[mattodd]

You mean of the synthesis itself? Back story in #311 It's a project running in parallel to our pursuit of Series 4 (the molecules for which we need a predictive model). The targets and uses are not related.

[mattodd]

Hi @vchioti just want to make sure you're following what's going on over at #374