Series 4: Which First 10 Compounds to Make?

[mattodd]

The first question for the community would be to decide on the best first 10 compounds to synthesise.
Obviously these may be contributed from anywhere.
We can also roll out Mike Robins' visual quiz system to ID the first 5, and we can potentially use other methods to solicit the other 5.

[mattodd]

Further to the meeting on Oct 10th, we need to an initial target list as one of the outcomes. This is our most pressing action item.

Initial punt (see also http://malaria.ourexperiment.org/uri/41f)

1. Resynthesis of MMV670652 and separation of its enantiomers
2. Resynthesis of key amides as proof of synthesis approach and to generate + and - compounds. See http://malaria.ourexperiment.org/uri/42d

What's missing here is a sense of which other amides to make - I'd like to defer decision on that till we have raw data for all compounds in the briefing doc - there may be patterns. @JoieG has suggested some in http://malaria.ourexperiment.org/uri/41f

[mattodd]

Also waiting on list of which compounds may already have physical samples available - Paul Willis says he will provide and that such a list exists.

[mattodd]

Potencies and availability of physical samples now posted online: http://malaria.ourexperiment.org/uri/438