Systemic mastocytosis (SM) affects the skin and also other organs and tissues in the body.
Subtypes:
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Indolent Systemic Mastocytosis: This is the most common subtype of systemic mastocytosis and is usually not associated with aggressive symptoms or organ damage.
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Systemic Mastocytosis with an Associated Hematologic Neoplasm (SM-AHN): This subtype is characterized by the presence of a second blood disorder, such as myelodysplastic syndrome or myeloproliferative neoplasms.
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Aggressive Systemic Mastocytosis (ASM): This subtype is more severe and may involve organ damage or failure.
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Mast Cell Leukemia (MCL): This is the rarest and most aggressive form of systemic mastocytosis, where mast cells accumulate in the bone marrow and peripheral blood.