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DESCRIPTION
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DESCRIPTION
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Package: drugdevelopR
Type: Package
Title: Utility-Based Optimal Phase II/III Drug Development Planning
Version: 1.0.1
Authors@R: c(person("Stella", "Erdmann",
email = "erdmann@imbi.uni-heidelberg.de", role = "aut"),
person("Johannes", "Cepicka", role = "aut"),
person("Marietta", "Kirchner", role = "aut"),
person("Meinhard", "Kieser", role = "aut"),
person("Lukas D.", "Sauer", email = "sauer@imbi.uni-heidelberg.de",
role = c("aut", "cre"),
comment = c(ORCID = "0000-0002-1340-9994")))
Author: Stella Erdmann [aut],
Johannes Cepicka [aut],
Marietta Kirchner [aut],
Meinhard Kieser [aut],
Lukas D. Sauer [aut, cre] (<https://orcid.org/0000-0002-1340-9994>)
Maintainer: Lukas D. Sauer <sauer@imbi.uni-heidelberg.de>
Description: Plan optimal sample size allocation and go/no-go decision rules
for phase II/III drug development programs with time-to-event, binary or
normally distributed endpoints when assuming fixed treatment effects or a
prior distribution for the treatment effect, using methods from Kirchner et al.
(2016) <doi:10.1002/sim.6624> and Preussler (2020). Optimal is in the sense of
maximal expected utility, where the utility is a function taking into account
the expected cost and benefit of the program. It is possible to extend to more
complex settings with bias correction (Preussler S et al. (2020)
<doi:10.1186/s12874-020-01093-w>), multiple phase III trials (Preussler et
al. (2019) <doi:10.1002/bimj.201700241>), multi-arm trials (Preussler et al.
(2019) <doi:10.1080/19466315.2019.1702092>), and multiple endpoints
(Kieser et al. (2018) <doi:10.1002/pst.1861>).
License: MIT + file LICENSE
Encoding: UTF-8
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.2.3
Depends:
R (>= 3.5.0),
doParallel,
parallel,
foreach,
iterators
Imports:
mvtnorm,
cubature,
msm,
MASS,
stats,
progressr
URL: https://github.com/Sterniii3/drugdevelopR,
https://sterniii3.github.io/drugdevelopR/
BugReports: https://github.com/Sterniii3/drugdevelopR/issues
Suggests:
rmarkdown,
knitr,
testthat (>= 3.0.0),
covr,
kableExtra,
magrittr,
devtools
VignetteBuilder: knitr
Config/testthat/parallel: true
Config/testthat/edition: 3