SoDCoD (Cu/Zn Superoxide Dismutase Conformational Diversity database)
This database contains information on the properties of 188 types of SOD1 mutants, including structural changes and binding to Derlin-1, as well as a set of genes that contribute to the proteostasis of mutant-like wild-type SOD1.
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data_MSIP_CT4interaction.txt
We conducted a comprehensive analysis of 188 SOD1 mutants concerning their structural alterations and interaction with Derlin-1.
This file contains information on the properties of 188 types of SOD1 mutants. -
data_screening.txt
We previously performed an siRNA screening to identify genes that contribute to the proteostasis of mutant-like wild-type SOD1.
This file contains information on the candidate genes that were positive in the screen.
Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants
Ann. Neurol., 72, 739-749 (2012)
https://doi.org/10.1002/ana.23668
Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto Y, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H
A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants
Neurobiol. Dis., 82, 478-486 (2015)
https://doi.org/10.1016/j.nbd.2015.08.010
Homma K, Takahashi H, Tsuburaya N, Naguro I, Fujisawa T and Ichijo H
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase
J. Biol. Chem., 295, 3148-3158 (2020)
https://doi.org/10.1074/jbc.RA119.010239
2023-04-20 Generated this repository on GitHub.
2023-08-29 Data updated.