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<?xml version="1.0" encoding="UTF-8" ?><xml><records><record><database name="example.enl" path="C:\Users\mjcou\Desktop\example.enl">example.enl</database><source-app name="EndNote" version="17.0">EndNote</source-app><rec-number>2</rec-number><foreign-keys><key app="EN" db-id="9aspew0wdtszvhevz5ppddfrt2paxdwxva29">2</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bond, G.</style></author><author><style face="normal" font="default" size="100%">Franchi, T.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Resuming cadaver dissection during a pandemic</style></title><secondary-title><style face="normal" font="default" size="100%">Medical education online</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Medical education online</style></full-title></periodical><pages><style face="normal" font="default" size="100%">1842661</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><number><style face="normal" font="default" size="100%">1</style></number><keywords><keyword><style face="normal" font="default" size="100%">anatomy</style></keyword><keyword><style face="normal" font="default" size="100%">Betacoronavirus</style></keyword><keyword><style face="normal" font="default" size="100%">cadaver</style></keyword><keyword><style face="normal" font="default" size="100%">Coronavirus infection</style></keyword><keyword><style face="normal" font="default" size="100%">dissection</style></keyword><keyword><style face="normal" font="default" size="100%">education</style></keyword><keyword><style face="normal" font="default" size="100%">human</style></keyword><keyword><style face="normal" font="default" size="100%">medical education</style></keyword><keyword><style face="normal" font="default" size="100%">medical student</style></keyword><keyword><style face="normal" font="default" size="100%">pandemic</style></keyword><keyword><style face="normal" font="default" size="100%">virus pneumonia</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2021</style></year></dates><isbn><style face="normal" font="default" size="100%">1087-2981</style></isbn><abstract><style face="normal" font="default" size="100%">Methods of anatomical education have, as with many facets of normal life, been forced to evolve rapidly due to the Covid-19 pandemic. Whilst some authors claim that cadaver dissection is now under threat, we believe the centuries-old practice can and must be upheld.</style></abstract><notes><style face="normal" font="default" size="100%">L633287662
2020-11-06
2020-11-19</style></notes><work-type><style face="normal" font="default" size="100%">Article</style></work-type><urls><related-urls><url><style face="normal" font="default" size="100%">https://www.embase.com/search/results?subaction=viewrecord&id=L633287662&from=export</style></url><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1080/10872981.2020.1842661</style></url></related-urls></urls><custom5><style face="normal" font="default" size="100%">33108248</style></custom5><electronic-resource-num><style face="normal" font="default" size="100%">10.1080/10872981.2020.1842661</style></electronic-resource-num><remote-database-name><style face="normal" font="default" size="100%">Medline</style></remote-database-name><language><style face="normal" font="default" size="100%">English</style></language></record><record><database name="example.enl" path="C:\Users\mjcou\Desktop\example.enl">example.enl</database><source-app name="EndNote" version="17.0">EndNote</source-app><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="9aspew0wdtszvhevz5ppddfrt2paxdwxva29">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bridwell, R.</style></author><author><style face="normal" font="default" size="100%">Long, B.</style></author><author><style face="normal" font="default" size="100%">Gottlieb, M.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">Department of Emergency Medicine, Brooke Army Medical Center, San Antonio, TX, United States of America.
Department of Emergency Medicine, Brooke Army Medical Center, San Antonio, TX, United States of America. Electronic address: Brit.long@yahoo.com.
Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, United States of America.</style></auth-address><titles><title><style face="normal" font="default" size="100%">Neurologic complications of COVID-19</style></title><secondary-title><style face="normal" font="default" size="100%">Am J Emerg Med</style></secondary-title><alt-title><style face="normal" font="default" size="100%">The American journal of emergency medicine</style></alt-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Am J Emerg Med</style></full-title><abbr-1><style face="normal" font="default" size="100%">The American journal of emergency medicine</style></abbr-1></periodical><alt-periodical><full-title><style face="normal" font="default" size="100%">Am J Emerg Med</style></full-title><abbr-1><style face="normal" font="default" size="100%">The American journal of emergency medicine</style></abbr-1></alt-periodical><pages><style face="normal" font="default" size="100%">1549.e3-1549.e7</style></pages><volume><style face="normal" font="default" size="100%">38</style></volume><number><style face="normal" font="default" size="100%">7</style></number><edition><style face="normal" font="default" size="100%">2020/05/20</style></edition><keywords><keyword><style face="normal" font="default" size="100%">Betacoronavirus</style></keyword><keyword><style face="normal" font="default" size="100%">Brain Diseases/etiology/physiopathology</style></keyword><keyword><style face="normal" font="default" size="100%">Cerebrovascular Disorders/etiology/physiopathology</style></keyword><keyword><style face="normal" font="default" size="100%">Coronavirus Infections/complications/*physiopathology</style></keyword><keyword><style face="normal" font="default" size="100%">Encephalitis/etiology/physiopathology</style></keyword><keyword><style face="normal" font="default" size="100%">Guillain-Barre Syndrome/etiology/physiopathology</style></keyword><keyword><style face="normal" font="default" size="100%">Humans</style></keyword><keyword><style face="normal" font="default" size="100%">Lymphohistiocytosis, Hemophagocytic/etiology/physiopathology</style></keyword><keyword><style face="normal" font="default" size="100%">Pandemics</style></keyword><keyword><style face="normal" font="default" size="100%">Pneumonia, Viral/complications/*physiopathology</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style face="normal" font="default" size="100%">Jul</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">0735-6757 (Print)
0735-6757</style></isbn><accession-num><style face="normal" font="default" size="100%">32425321</style></accession-num><abstract><style face="normal" font="default" size="100%">BACKGROUND: Much of the focus regarding the global pandemic of coronavirus disease of 2019 (COVID-19) has been on the cardiovascular, pulmonary, and hematologic complications. However, neurologic complications have arisen as an increasingly recognized area of morbidity and mortality. OBJECTIVE: This brief report summarizes the neurologic complications associated with COVID-19 with an emphasis on the emergency medicine clinician. DISCUSSION: COVID-19 has infected over 3.5 million people and killed over 240,000 people worldwide. While pulmonary complications are profound, the neurologic system is also significantly impacted, with complications including acute cerebrovascular events, encephalitis, Guillain-Barré syndrome, acute necrotizing hemorrhagic encephalopathy, and hemophagocytic lymphohistiocytosis. Additionally, patients on immunosuppressive medications for pre-existing neurologic issues are at an increased risk for complications with COVID-19 infection, and many of the currently proposed COVID-19 therapies can interact with these medications. CONCLUSIONS: When caring for COVID-19 patients, emergency medicine clinicians should be aware of the neurologic complications from COVID-19.</style></abstract><notes><style face="normal" font="default" size="100%">1532-8171
Bridwell, Rachel
Long, Brit
Gottlieb, Michael
Journal Article
Review
Am J Emerg Med. 2020 Jul;38(7):1549.e3-1549.e7. doi: 10.1016/j.ajem.2020.05.024. Epub 2020 May 16.</style></notes><urls></urls><custom2><style face="normal" font="default" size="100%">Pmc7229718</style></custom2><electronic-resource-num><style face="normal" font="default" size="100%">10.1016/j.ajem.2020.05.024</style></electronic-resource-num><remote-database-provider><style face="normal" font="default" size="100%">Nlm</style></remote-database-provider><language><style face="normal" font="default" size="100%">eng</style></language></record><record><database name="example.enl" path="C:\Users\mjcou\Desktop\example.enl">example.enl</database><source-app name="EndNote" version="17.0">EndNote</source-app><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="9aspew0wdtszvhevz5ppddfrt2paxdwxva29">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carrasco-Sánchez, F. J.</style></author><author><style face="normal" font="default" size="100%">López-Carmona, M. D.</style></author><author><style face="normal" font="default" size="100%">Martínez-Marcos, F. J.</style></author><author><style face="normal" font="default" size="100%">Pérez-Belmonte, L. M.</style></author><author><style face="normal" font="default" size="100%">Hidalgo-Jiménez, A.</style></author><author><style face="normal" font="default" size="100%">Buonaiuto, V.</style></author><author><style face="normal" font="default" size="100%">Suárez Fernández, C.</style></author><author><style face="normal" font="default" size="100%">Freire Castro, S. J.</style></author><author><style face="normal" font="default" size="100%">Luordo, D.</style></author><author><style face="normal" font="default" size="100%">Pesqueira Fontan, P. M.</style></author><author><style face="normal" font="default" size="100%">Blázquez Encinar, J. C.</style></author><author><style face="normal" font="default" size="100%">Magallanes Gamboa, J. O.</style></author><author><style face="normal" font="default" size="100%">de la Peña Fernández, A.</style></author><author><style face="normal" font="default" size="100%">Torres Peña, J. D.</style></author><author><style face="normal" font="default" size="100%">Fernández Solà, J.</style></author><author><style face="normal" font="default" size="100%">Napal Lecumberri, J. J.</style></author><author><style face="normal" font="default" size="100%">Amorós Martínez, F.</style></author><author><style face="normal" font="default" size="100%">Guisado Espartero, M. E.</style></author><author><style face="normal" font="default" size="100%">Jorge Ripper, C.</style></author><author><style face="normal" font="default" size="100%">Gómez Méndez, R.</style></author><author><style face="normal" font="default" size="100%">Vicente López, N.</style></author><author><style face="normal" font="default" size="100%">Román Bernal, B.</style></author><author><style face="normal" font="default" size="100%">Rojano Rivero, M. G.</style></author><author><style face="normal" font="default" size="100%">Ramos Rincón, J. M.</style></author><author><style face="normal" font="default" size="100%">Gómez Huelgas, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry</style></title><secondary-title><style face="normal" font="default" size="100%">Annals of medicine</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Annals of medicine</style></full-title></periodical><pages><style face="normal" font="default" size="100%">103-116</style></pages><volume><style face="normal" font="default" size="100%">53</style></volume><number><style face="normal" font="default" size="100%">1</style></number><keywords><keyword><style face="normal" font="default" size="100%">aged</style></keyword><keyword><style face="normal" font="default" size="100%">artificial ventilation</style></keyword><keyword><style face="normal" font="default" size="100%">blood</style></keyword><keyword><style face="normal" font="default" size="100%">complication</style></keyword><keyword><style face="normal" font="default" size="100%">Coronavirus infection</style></keyword><keyword><style face="normal" font="default" size="100%">epidemiology</style></keyword><keyword><style face="normal" font="default" size="100%">female</style></keyword><keyword><style face="normal" font="default" size="100%">glucose blood level</style></keyword><keyword><style face="normal" font="default" size="100%">human</style></keyword><keyword><style face="normal" font="default" size="100%">hyperglycemia</style></keyword><keyword><style face="normal" font="default" size="100%">intensive care</style></keyword><keyword><style face="normal" font="default" size="100%">length of stay</style></keyword><keyword><style face="normal" font="default" size="100%">male</style></keyword><keyword><style face="normal" font="default" size="100%">middle aged</style></keyword><keyword><style face="normal" font="default" size="100%">mortality</style></keyword><keyword><style face="normal" font="default" size="100%">pandemic</style></keyword><keyword><style face="normal" font="default" size="100%">register</style></keyword><keyword><style face="normal" font="default" size="100%">Spain</style></keyword><keyword><style face="normal" font="default" size="100%">very elderly</style></keyword><keyword><style face="normal" font="default" size="100%">virus pneumonia</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2021</style></year></dates><isbn><style face="normal" font="default" size="100%">1365-2060</style></isbn><abstract><style face="normal" font="default" size="100%">BACKGROUND: Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS: This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality. RESULTS: Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140-180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality. CONCLUSIONS: Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes. KEY MESSAGE Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19. Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19. Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.</style></abstract><notes><style face="normal" font="default" size="100%">L633189721
2020-10-27
2020-11-20</style></notes><work-type><style face="normal" font="default" size="100%">Article</style></work-type><urls><related-urls><url><style face="normal" font="default" size="100%">https://www.embase.com/search/results?subaction=viewrecord&id=L633189721&from=export</style></url><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.1080/07853890.2020.1836566</style></url></related-urls></urls><custom5><style face="normal" font="default" size="100%">33063540</style></custom5><electronic-resource-num><style face="normal" font="default" size="100%">10.1080/07853890.2020.1836566</style></electronic-resource-num><remote-database-name><style face="normal" font="default" size="100%">Medline</style></remote-database-name><language><style face="normal" font="default" size="100%">English</style></language></record><record><database name="example.enl" path="C:\Users\mjcou\Desktop\example.enl">example.enl</database><source-app name="EndNote" version="17.0">EndNote</source-app><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="9aspew0wdtszvhevz5ppddfrt2paxdwxva29">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daoud, S.</style></author><author><style face="normal" font="default" size="100%">Alabed, S. J.</style></author><author><style face="normal" font="default" size="100%">Dahabiyeh, L. A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification of potential COVID-19 main protease inhibitors using structure-based pharmacophore approach, molecular docking and repurposing studies</style></title><secondary-title><style face="normal" font="default" size="100%">Acta pharmaceutica (Zagreb, Croatia)</style></secondary-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Acta pharmaceutica (Zagreb, Croatia)</style></full-title></periodical><pages><style face="normal" font="default" size="100%">163-174</style></pages><volume><style face="normal" font="default" size="100%">71</style></volume><number><style face="normal" font="default" size="100%">2</style></number><keywords><keyword><style face="normal" font="default" size="100%">adenosine phosphate</style></keyword><keyword><style face="normal" font="default" size="100%">alanine</style></keyword><keyword><style face="normal" font="default" size="100%">antivirus agent</style></keyword><keyword><style face="normal" font="default" size="100%">proteinase inhibitor</style></keyword><keyword><style face="normal" font="default" size="100%">remdesivir</style></keyword><keyword><style face="normal" font="default" size="100%">chemical model</style></keyword><keyword><style face="normal" font="default" size="100%">chemical structure</style></keyword><keyword><style face="normal" font="default" size="100%">chemistry</style></keyword><keyword><style face="normal" font="default" size="100%">Coronavirus infection</style></keyword><keyword><style face="normal" font="default" size="100%">drug development</style></keyword><keyword><style face="normal" font="default" size="100%">drug repositioning</style></keyword><keyword><style face="normal" font="default" size="100%">enzymology</style></keyword><keyword><style face="normal" font="default" size="100%">human</style></keyword><keyword><style face="normal" font="default" size="100%">molecular docking</style></keyword><keyword><style face="normal" font="default" size="100%">pandemic</style></keyword><keyword><style face="normal" font="default" size="100%">procedures</style></keyword><keyword><style face="normal" font="default" size="100%">structure activity relation</style></keyword><keyword><style face="normal" font="default" size="100%">virus pneumonia</style></keyword><keyword><style face="normal" font="default" size="100%">X ray crystallography</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2021</style></year></dates><isbn><style face="normal" font="default" size="100%">1846-9558</style></isbn><abstract><style face="normal" font="default" size="100%">The current outbreak of novel coronavirus (COVID-19) infections urges the need to identify potential therapeutic agents. Therefore, the repurposing of FDA-approved drugs against today's diseases involves the use of de-risked compounds with potentially lower costs and shorter development timelines. In this study, the recently resolved X-ray crystallographic structure of COVID-19 main protease (Mpro) was used to generate a pharmacophore model and to conduct a docking study to capture antiviral drugs as new promising COVID-19 main protease inhibitors. The developed pharmacophore successfully captured five FDA-approved antiviral drugs (lopinavir, remdesivir, ritonavir, saquinavir and raltegravir). The five drugs were successfully docked into the binding site of COVID-19 Mpro and showed several specific binding interactions that were comparable to those tying the co-crystallized inhibitor X77 inside the binding site of COVID-19 Mpro. Three of the captured drugs namely, remdesivir, lopinavir and ritonavir, were reported to have promising results in COVID-19 treatment and therefore increases the confidence in our results. Our findings suggest an additional possible mechanism of action for remdesivir as an antiviral drug inhibiting COVID-19 Mpro. Additionally, a combination of structure-based pharmacophore modeling with a docking study is expected to facilitate the discovery of novel COVID-19 Mpro inhibitors.</style></abstract><notes><style face="normal" font="default" size="100%">L633350253
2020-11-12
2020-11-20</style></notes><work-type><style face="normal" font="default" size="100%">Article</style></work-type><urls><related-urls><url><style face="normal" font="default" size="100%">https://www.embase.com/search/results?subaction=viewrecord&id=L633350253&from=export</style></url><url><style face="normal" font="default" size="100%">http://dx.doi.org/10.2478/acph-2021-0016</style></url></related-urls></urls><custom5><style face="normal" font="default" size="100%">33151166</style></custom5><electronic-resource-num><style face="normal" font="default" size="100%">10.2478/acph-2021-0016</style></electronic-resource-num><remote-database-name><style face="normal" font="default" size="100%">Medline</style></remote-database-name><language><style face="normal" font="default" size="100%">English</style></language></record><record><database name="example.enl" path="C:\Users\mjcou\Desktop\example.enl">example.enl</database><source-app name="EndNote" version="17.0">EndNote</source-app><rec-number>6</rec-number><foreign-keys><key app="EN" db-id="9aspew0wdtszvhevz5ppddfrt2paxdwxva29">6</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kannan, S.</style></author><author><style face="normal" font="default" size="100%">Shaik Syed Ali, P.</style></author><author><style face="normal" font="default" size="100%">Sheeza, A.</style></author><author><style face="normal" font="default" size="100%">Hemalatha, K.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">School of Medicine, The Maldives National University, Male', Maldives. Kannan.subbaram@mnu.edu.mv.</style></auth-address><titles><title><style face="normal" font="default" size="100%">COVID-19 (Novel Coronavirus 2019) - recent trends</style></title><secondary-title><style face="normal" font="default" size="100%">Eur Rev Med Pharmacol Sci</style></secondary-title><alt-title><style face="normal" font="default" size="100%">European review for medical and pharmacological sciences</style></alt-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Eur Rev Med Pharmacol Sci</style></full-title><abbr-1><style face="normal" font="default" size="100%">European review for medical and pharmacological sciences</style></abbr-1></periodical><alt-periodical><full-title><style face="normal" font="default" size="100%">Eur Rev Med Pharmacol Sci</style></full-title><abbr-1><style face="normal" font="default" size="100%">European review for medical and pharmacological sciences</style></abbr-1></alt-periodical><pages><style face="normal" font="default" size="100%">2006-2011</style></pages><volume><style face="normal" font="default" size="100%">24</style></volume><number><style face="normal" font="default" size="100%">4</style></number><edition><style face="normal" font="default" size="100%">2020/03/07</style></edition><keywords><keyword><style face="normal" font="default" size="100%">Animals</style></keyword><keyword><style face="normal" font="default" size="100%">*Betacoronavirus/chemistry/genetics/metabolism</style></keyword><keyword><style face="normal" font="default" size="100%">*Coronavirus Infections/diagnosis/epidemiology</style></keyword><keyword><style face="normal" font="default" size="100%">Genome, Viral</style></keyword><keyword><style face="normal" font="default" size="100%">Humans</style></keyword><keyword><style face="normal" font="default" size="100%">Nucleocapsid Proteins/chemistry/genetics/metabolism</style></keyword><keyword><style face="normal" font="default" size="100%">*Pneumonia, Viral/diagnosis/epidemiology</style></keyword><keyword><style face="normal" font="default" size="100%">Virus Activation</style></keyword><keyword><style face="normal" font="default" size="100%">World Health Organization</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style face="normal" font="default" size="100%">Feb</style></date></pub-dates></dates><isbn><style face="normal" font="default" size="100%">1128-3602</style></isbn><accession-num><style face="normal" font="default" size="100%">32141569</style></accession-num><abstract><style face="normal" font="default" size="100%">The World Health Organization (WHO) has issued a warning that, although the 2019 novel coronavirus (COVID-19) from Wuhan City (China), is not pandemic, it should be contained to prevent the global spread. The COVID-19 virus was known earlier as 2019-nCoV. As of 12 February 2020, WHO reported 45,171 cases and 1115 deaths related to COVID-19. COVID-19 is similar to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) virus in its pathogenicity, clinical spectrum, and epidemiology. Comparison of the genome sequences of COVID-19, SARS-CoV, and Middle East Respiratory Syndrome coronavirus (MERS-CoV) showed that COVID-19 has a better sequence identity with SARS-CoV compared to MERS CoV. However, the amino acid sequence of COVID-19 differs from other coronaviruses specifically in the regions of 1ab polyprotein and surface glycoprotein or S-protein. Although several animals have been speculated to be a reservoir for COVID-19, no animal reservoir has been already confirmed. COVID-19 causes COVID-19 disease that has similar symptoms as SARS-CoV. Studies suggest that the human receptor for COVID-19 may be angiotensin-converting enzyme 2 (ACE2) receptor similar to that of SARS-CoV. The nucleocapsid (N) protein of COVID-19 has nearly 90% amino acid sequence identity with SARS-CoV. The N protein antibodies of SARS-CoV may cross react with COVID-19 but may not provide cross-immunity. In a similar fashion to SARS-CoV, the N protein of COVID-19 may play an important role in suppressing the RNA interference (RNAi) to overcome the host defense. This mini-review aims at investigating the most recent trend of COVID-19.</style></abstract><notes><style face="normal" font="default" size="100%">2284-0729
Kannan, S
Shaik Syed Ali, P
Sheeza, A
Hemalatha, K
Journal Article
Review
Italy
Eur Rev Med Pharmacol Sci. 2020 Feb;24(4):2006-2011. doi: 10.26355/eurrev_202002_20378.</style></notes><urls></urls><electronic-resource-num><style face="normal" font="default" size="100%">10.26355/eurrev_202002_20378</style></electronic-resource-num><remote-database-provider><style face="normal" font="default" size="100%">Nlm</style></remote-database-provider><language><style face="normal" font="default" size="100%">eng</style></language></record><record><database name="example.enl" path="C:\Users\mjcou\Desktop\example.enl">example.enl</database><source-app name="EndNote" version="17.0">EndNote</source-app><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="9aspew0wdtszvhevz5ppddfrt2paxdwxva29">4</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Trejo-Gabriel-Galán, J. M.</style></author></authors></contributors><auth-address><style face="normal" font="default" size="100%">Servicio de Neurología, Hospital Universitario de Burgos, Burgos, España. Electronic address: jtrejogyg@gmail.com.</style></auth-address><titles><title><style face="normal" font="default" size="100%">Stroke as a complication and prognostic factor of COVID-19</style></title><secondary-title><style face="normal" font="default" size="100%">Neurologia</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Neurologia (Barcelona, Spain)</style></alt-title></titles><periodical><full-title><style face="normal" font="default" size="100%">Neurologia</style></full-title><abbr-1><style face="normal" font="default" size="100%">Neurologia (Barcelona, Spain)</style></abbr-1></periodical><alt-periodical><full-title><style face="normal" font="default" size="100%">Neurologia</style></full-title><abbr-1><style face="normal" font="default" size="100%">Neurologia (Barcelona, Spain)</style></abbr-1></alt-periodical><pages><style face="normal" font="default" size="100%">318-322</style></pages><volume><style face="normal" font="default" size="100%">35</style></volume><number><style face="normal" font="default" size="100%">5</style></number><edition><style face="normal" font="default" size="100%">2020/06/05</style></edition><keywords><keyword><style face="normal" font="default" size="100%">Betacoronavirus/isolation & purification</style></keyword><keyword><style face="normal" font="default" size="100%">Central Nervous System/*virology</style></keyword><keyword><style face="normal" font="default" size="100%">Central Nervous System Viral Diseases/*pathology/*virology</style></keyword><keyword><style face="normal" font="default" size="100%">Coronavirus Infections/*complications/virology</style></keyword><keyword><style face="normal" font="default" size="100%">Humans</style></keyword><keyword><style face="normal" font="default" size="100%">Pandemics</style></keyword><keyword><style face="normal" font="default" size="100%">Pneumonia, Viral/*complications/virology</style></keyword><keyword><style face="normal" font="default" size="100%">Prognosis</style></keyword><keyword><style face="normal" font="default" size="100%">Stroke/*virology</style></keyword></keywords><dates><year><style face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style face="normal" font="default" size="100%">Jun</style></date></pub-dates></dates><orig-pub><style face="normal" font="default" size="100%">Ictus como complicación y como factor pronóstico de COVID-19.</style></orig-pub><isbn><style face="normal" font="default" size="100%">0213-4853 (Print)
0213-4853</style></isbn><accession-num><style face="normal" font="default" size="100%">32493597</style></accession-num><abstract><style face="normal" font="default" size="100%">INTRODUCTION: Contradictory data have been reported on the incidence of stroke in patients with COVID-19 and the risk of SARS-CoV-2 infection among patients with history of stroke. METHODS: This study systematically reviews case series reporting stroke as a complication of COVID-19, and analyses the prognosis of patients with COVID-19 and history of stroke. The pathophysiological mechanisms of stroke in patients with COVID-19 are also reviewed. CONCLUSIONS: History of stroke increases the risk of death due to COVID-19 by 3 times. Stroke currently seems not to be one of the main complications of COVID-19.</style></abstract><notes><style face="normal" font="default" size="100%">1578-1968
Trejo-Gabriel-Galán, J M
Journal Article
Review
Neurologia. 2020 Jun;35(5):318-322. doi: 10.1016/j.nrl.2020.04.015. Epub 2020 May 6.</style></notes><urls></urls><custom2><style face="normal" font="default" size="100%">PMC7200328 patients with COVID-19 and the risk of SARS-CoV-2 infection among patients with history of stroke. METHODS: This study systematically reviews case series reporting stroke as a complication of COVID-19, and analyses the prognosis of patients with COVID-19 and history of stroke. The pathophysiological mechanisms of stroke in patients with COVID-19 are also reviewed. CONCLUSIONS: History of stroke increases the risk of death due to COVID-19 by 3 times. Stroke currently seems not to be one of the main complications of COVID-19.</style></custom2><electronic-resource-num><style face="normal" font="default" size="100%">10.1016/j.nrl.2020.04.015</style></electronic-resource-num><remote-database-provider><style face="normal" font="default" size="100%">Nlm</style></remote-database-provider><language><style face="normal" font="default" size="100%">eng
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