Covariates per subject

[rhocertara]

Hello Andrew,
I am looking for a best way to include different covariates (e.g. weight, race, etc.). I have seen that one can add such in the "create_design" way but this seems to be good for some specifications per group. I would like to know if one can properly implement, for instance, an specific weight per subject for CL.
Thank you very much for your help in advance.
Roberto

[andrewhooker]

Hi Roberto, You can do this. The problem is that you slow down the computation of the FIM for the design, making optimization harder. Please see the attached file. Best regards, Andy [covariate_distributions_2.pdf](https://github.com/andrewhooker/PopED/files/1990465/covariate_distributions_2.pdf)