-
Notifications
You must be signed in to change notification settings - Fork 20
New issue
Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.
By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.
Already on GitHub? Sign in to your account
Two questions #72
Comments
For dynamic transform of both sides, I suppose I could add the objective function correction using a new ofv that relies on https://github.com/andrewhooker/PopED/blob/master/R%2Fofv_fim.R But I don't think it is needed.... I'm not confident enough in the methodology to really know. In general I cannot find the "y" value that would lend itself to the |
Looking through the examples this is a clear no. I guess the fixed sigma trick that works in NONMEM does not work here. |
I also noticed that the prediction functions return DV so there must be some sort of DV prediction. So dynamic transform of both sides won't work 100% by simply transforming the f value. |
Hi @andrewhooker,
I have two questions:
sigma
is fixed to one and the additive error is defined in theff
model. When runningevaluate_design
the residual components are not being estimated in thefim
:Is fixing the
add.err
component equivalent to what is done?f
. In dynamic transformation of both sides in NONMEM there is an objective function adjustment. Is that needed?Thanks
The answers to these two questions will help me produce an interface between
nlmixr2
andPopED
.The text was updated successfully, but these errors were encountered: