predicate_mapping.yaml

predicate mappings:
  - mapped predicate: augments
    object aspect qualifier: activity or abundance
    object direction qualifier: increased
    predicate: affects
    qualified predicate: causes
    exact matches:
      - SEMMEDDB:AUGMENTS
  - mapped predicate: affects abundance of
    object aspect qualifier: abundance
    predicate: affects
    exact matches:
      - CTD:affects_abundance_of
  - mapped predicate: increases abundance of
    object aspect qualifier: abundance
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_abundance_of
  - mapped predicate: decreases abundance of
    object aspect qualifier: abundance
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_abundance_of
  - mapped predicate: affects activity or abundance of
    object aspect qualifier: activity or abundance
    predicate: affects
    qualified predicate: causes
  - mapped predicate: increases activity or abundance of
    object aspect qualifier: activity or abundance
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
  - mapped predicate: decreases activity or abundance of
    object aspect qualifier: activity or abundance
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
  - mapped predicate: affects activity of
    object aspect qualifier: activity
    predicate: affects
    exact matches:
      - CTD:affects_activity_of
      - DGIdb:modulator
  - mapped predicate: increases activity of
    object aspect qualifier: activity
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_activity_of
      - CHEMBL.MECHANISM:opener
      - CHEMBL.MECHANISM:positive_modulator
      - CHEMBL.MECHANISM:releasing_agent
      - DGIdb:activator
      - DGIdb:agonist
    narrow matches:
      - DGIdb:partial_agonist
      - SEMMEDDB:STIMULATES
  - mapped predicate: decreases activity of
    object aspect qualifier: activity
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_activity_of
      - GAMMA:ic50
      - GAMMA:ki
      - DGIdb:vaccine
      - DGIdb:antagonist
      - DGIdb:blocker
      - DGIdb:channel_blocker
      - DGIdb:gating_inhibitor
      - CHEMBL.MECHANISM:antisense_inhibitor
      - CHEMBL.MECHANISM:blocker
      - CHEMBL.MECHANISM:inhibitor
      - CHEMBL.MECHANISM:negative_allosteric_modulator
      - CHEMBL.MECHANISM:negative_modulator
      - DGIdb:negative_modulator
      - DGIdb:inverse_agonist
      - SEMMEDDB:INHIBITS
      - DGIdb:inhibitor
  - mapped predicate: affects expression of
    object aspect qualifier: expression
    predicate: affects
    exact matches:
      - CTD:affects_expression_of
      - GTEx:affects_expression_in
  - mapped predicate: increases expression of
    object aspect qualifier: expression
    object direction qualifier: increased
    predicate: affects
    qualified predicate: causes
    exact matches:
      - RO:0003003
      - CTD:increases_expression_of
  - mapped predicate: decreases expression of
    object aspect qualifier: expression
    object direction qualifier: decreased
    predicate: affects
    qualified predicate: causes
    exact matches:
      - RO:0003002
      - CTD:decreases_expression_of
  - mapped predicate: affects folding of
    object aspect qualifier: folding
    predicate: affects
    exact matches:
      - CTD:affects_folding_of
  - mapped predicate: increases folding of
    object aspect qualifier: folding
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_folding_of
  - mapped predicate: decreases folding of
    object aspect qualifier: folding
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_folding_of
  - mapped predicate: affects localization of
    object aspect qualifier: localization
    predicate: affects
    exact matches:
      - CTD:affects_localization_of
      - GOREL:0002003
  - mapped predicate: increases localization of
    object aspect qualifier: localization
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_localization_of
  - mapped predicate: decreases localization of
    object aspect qualifier: localization
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_localization_of
  - mapped predicate: affects molecular modification of
    object aspect qualifier: molecular modification
    predicate: affects
    exact matches:
      - CTD:affects_molecular_modification_of
    narrow matches:
      - CTD:affects_acetylation
      - CTD:affects_acylation
      - CTD:affects_alkylation
      - CTD:affects_amination
      - CTD:affects_carbamoylation
      - CTD:affects_ethylation
      - CTD:affects_glutathionylation
      - CTD:affects_glycation
      - CTD:affects_glycosylation
      - CTD:affects_glucuronidation
      - CTD:affects_N-linked_glycosylation
      - CTD:affects_O-linked_glycosylation
      - CTD:affects_hydroxylation
      - CTD:affects_lipidation
      - CTD:affects_farnesylation
      - CTD:affects_geranoylation
      - CTD:affects_myristoylation
      - CTD:affects_palmitoylation
      - CTD:affects_prenylation
      - CTD:affects_methylation
      - CTD:affects_nitrosation
      - CTD:affects_nucleotidylation
      - CTD:affects_phosphorylation
      - CTD:affects_ribosylation
      - CTD:affects_ADP-ribosylation
      - CTD:affects_sulfation
      - CTD:affects_sumoylation
      - CTD:affects_ubiquitination
      - CTD:affects_oxidation
      - CTD:affects_reduction
      - CTD:affects_carboxylation
  - mapped predicate: increases molecular modification of
    object aspect qualifier: molecular modification
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_molecular_modification_of
    narrow matches:
      - CTD:increases_acetylation
      - CTD:increases_acylation
      - CTD:increases_alkylation
      - CTD:increases_amination
      - CTD:increases_carbamoylation
      - CTD:increases_ethylation
      - CTD:increases_glutathionylation
      - CTD:increases_glycation
      - CTD:increases_glycosylation
      - CTD:increases_glucuronidation
      - CTD:increases_N-linked_glycosylation
      - CTD:increases_O-linked_glycosylation
      - CTD:increases_hydroxylation
      - CTD:increases_lipidation
      - CTD:increases_farnesylation
      - CTD:increases_geranoylation
      - CTD:increases_myristoylation
      - CTD:increases_palmitoylation
      - CTD:increases_prenylation
      - CTD:increases_methylation
      - CTD:increases_nitrosation
      - CTD:increases_nucleotidylation
      - CTD:increases_phosphorylation
      - CTD:increases_ribosylation
      - CTD:increases_ADP-ribosylation
      - CTD:increases_sulfation
      - CTD:increases_sumoylation
      - CTD:increases_ubiquitination
      - CTD:increases_oxidation
      - CTD:increases_reduction
      - CTD:increases_carboxylation
      - GAMMA:acetylation
      - GAMMA:oxidizer
  - mapped predicate: decreases molecular modification of
    object aspect qualifier: molecular modification
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_molecular_modification_of
    narrow matches:
      - CTD:decreases_acetylation
      - CTD:decreases_acylation
      - CTD:decreases_alkylation
      - CTD:decreases_amination
      - CTD:decreases_carbamoylation
      - CTD:decreases_ethylation
      - CTD:decreases_glutathionylation
      - CTD:decreases_glycation
      - CTD:decreases_glycosylation
      - CTD:decreases_glucuronidation
      - CTD:decreases_N-linked_glycosylation
      - CTD:decreases_O-linked_glycosylation
      - CTD:decreases_hydroxylation
      - CTD:decreases_lipidation
      - CTD:decreases_farnesylation
      - CTD:decreases_geranoylation
      - CTD:decreases_myristoylation
      - CTD:decreases_palmitoylation
      - CTD:decreases_prenylation
      - CTD:decreases_methylation
      - CTD:decreases_nitrosation
      - CTD:decreases_nucleotidylation
      - CTD:decreases_phosphorylation
      - CTD:decreases_ribosylation
      - CTD:decreases_ADP-ribosylation
      - CTD:decreases_sulfation
      - CTD:decreases_sumoylation
      - CTD:decreases_ubiquitination
      - CTD:decreases_oxidation
      - CTD:decreases_reduction
      - CTD:decreases_carboxylation
      - GAMMA:deoxidizer
  - mapped predicate: affects metabolic processing of
    object aspect qualifier: metabolic processing
    predicate: affects
    exact matches:
      - CTD:affects_metabolic_processing_of
  - mapped predicate: increases metabolic processing of
    object aspect qualifier: metabolic processing
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_metabolic_processing_of
  - mapped predicate: decreases metabolic processing of
    object aspect qualifier: metabolic processing
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_metabolic_processing_of
  - mapped predicate: affects synthesis of
    object aspect qualifier: synthesis
    predicate: affects
    exact matches:
      - CTD:affects_synthesis_of
  - mapped predicate: increases synthesis of
    object aspect qualifier: synthesis
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_synthesis_of
  - mapped predicate: decreases synthesis of
    object aspect qualifier: synthesis
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_synthesis_of
  - mapped predicate: affects transport of
    object aspect qualifier: transport
    predicate: affects
    exact matches:
      - CTD:affects_transport_of
  - mapped predicate: increases transport of
    object aspect qualifier: transport
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_transport_of
    narrow matches:
      - GAMMA:carrier
      - GAMMA:transporter
      - RO:0002313
      - RO:0002340
      - RO:0002345
  - mapped predicate: decreases transport of
    object aspect qualifier: transport
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_transport_of
  - mapped predicate: affects degradation of
    object aspect qualifier: degradation
    predicate: affects
    exact matches:
      - CTD:affects_degradation_of
  - mapped predicate: increases degradation of
    object aspect qualifier: degradation
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_degradation_of
      - CTD:increases_cleavage
      - CTD:increases_hydrolysis
      - GOREL:0002004
  - mapped predicate: decreases degradation of
    object aspect qualifier: degradation
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_degradation_of
      - CTD:decreases_cleavage
      - CTD:decreases_hydrolysis
  - mapped predicate: affects secretion of
    object aspect qualifier: secretion
    predicate: affects
    exact matches:
      - CTD:affects_secretion_of
    broad matches:
      - CTD:affects_export
  - mapped predicate: increases secretion of
    object aspect qualifier: secretion
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_secretion_of
  - mapped predicate: decreases secretion of
    object aspect qualifier: secretion
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_secretion_of
  - mapped predicate: affects mutation rate of
    object aspect qualifier: mutation rate
    predicate: affects
    exact matches:
      - CTD:affects_mutation_rate_of
  - mapped predicate: increases mutation rate of
    object aspect qualifier: mutation rate
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_mutation_rate_of
      - CTD:increases_mutagenesis
  - mapped predicate: decreases mutation rate of
    object aspect qualifier: mutation rate
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_mutation_rate_of
      - CTD:decreases_mutagenesis
  - mapped predicate: affects splicing of
    object aspect qualifier: splicing
    predicate: affects
    exact matches:
      - CTD:affects_splicing_of
  - mapped predicate: increases splicing of
    object aspect qualifier: splicing
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_splicing_of
      - CTD:increases_RNA_splicing
  - mapped predicate: decreases splicing of
    object aspect qualifier: splicing
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_splicing_of
      - CTD:decreases_RNA_splicing
  - mapped predicate: affects splicing of
    object aspect qualifier: splicing
    predicate: affects
    exact matches:
      - CTD:affects_splicing_of
  - mapped predicate: increases splicing of
    object aspect qualifier: splicing
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_splicing_of
  - mapped predicate: decreases splicing of
    object aspect qualifier: splicing
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_splicing_of
  - mapped predicate: affects secretion of
    object aspect qualifier: secretion
    predicate: affects
    exact matches:
      - CTD:affects_secretion_of
  - mapped predicate: increases secretion of
    object aspect qualifier: secretion
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_secretion_of
  - mapped predicate: decreases secretion of
    object aspect qualifier: secretion
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_secretion_of
  - mapped predicate: affects uptake of
    object aspect qualifier: uptake
    predicate: affects
    exact matches:
      - CTD:affects_uptake_of
    broad matches:
      - CTD:affects_import
  - mapped predicate: increases uptake of
    object aspect qualifier: uptake
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_uptake_of
    broad matches:
      - CTD:increases_import
  - mapped predicate: decreases uptake of
    object aspect qualifier: uptake
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_uptake_of
    broad matches:
      # 'import' more general than 'uptake'
      - CTD:decreases_import
  - mapped predicate: affects molecular interaction
    object aspect qualifier: molecular interaction
    predicate: affects
    exact matches:
      - CTD:affects_molecular_interaction
  - mapped predicate: increases molecular interaction
    object aspect qualifier: molecular interaction
    object direction qualifier: increased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:increases_molecular_interaction
  - mapped predicate: decreases molecular interaction
    object aspect qualifier: molecular interaction
    object direction qualifier: decreased
    qualified predicate: causes
    predicate: affects
    exact matches:
      - CTD:decreases_molecular_interaction
  - mapped predicate: entity negatively regulates entity
    object direction qualifier: downregulated
    predicate: regulates
    exact matches:
      - RO:0002212
      - RO:0002449
  - mapped predicate: entity positively regulates entity
    object direction qualifier: upregulated
    predicate: regulates
    exact matches:
      - RO:0002450
  - mapped predicate: process positively regulates process
    object direction qualifier: upregulated
    predicate: regulates
    exact matches:
      - RO:0002213
  - mapped predicate: process negatively regulates process
    object direction qualifier: downregulated
    predicate: regulates
    exact matches:
      - RO:0002212