notebooks/Summarize_GOTerm_Descendants.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Summarizing annotations to a term and descendants\n",
    "\n",
    "This notebook demonstrates summarizing annotation counts for a term and its descendants.\n",
    "\n",
    "An example use of this is a GO annotator exploring refactoring a subtree in GO\n",
    "\n",
    "Of course, if this were a regular thing we would make a command line or even web interface,\n",
    "but keeping as a notebook gives us some flexibility in logic, and anyway is intended largely\n",
    "as a demonstration"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### boilerplate\n",
    "\n",
    " * importing relevant ontobiolibraries\n",
    " * set up key objects"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "\n",
    "## Create an ontology factory in order to fetch GO\n",
    "from ontobio.ontol_factory import OntologyFactory\n",
    "ofactory = OntologyFactory()\n",
    "\n",
    "## GOLR queries\n",
    "from ontobio.golr.golr_query import GolrAssociationQuery\n",
    "\n",
    "## rendering ontologies\n",
    "from ontobio import GraphRenderer"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "## Load GO. Note the first time this runs Jupyter will show '*' - be patient\n",
    "ont = ofactory.create(\"go\")  "
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Finding descendants\n",
    "\n",
    "Here we are using the in-memory ontology object, no external service calls are executed\n",
    "\n",
    "Change the value of `term_id` to what you like"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [],
   "source": [
    "term_id = \"GO:0009070\" ## serine family amino acid biosynthetic process\n",
    "descendants = ont.descendants(term_id, reflexive=True, relations=['subClassOf', 'BFO:0000050'])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['GO:0016260',\n",
       " 'GO:0004124',\n",
       " 'GO:0019343',\n",
       " 'GO:0019265',\n",
       " 'GO:0019345',\n",
       " 'GO:0006564',\n",
       " 'GO:0006545',\n",
       " 'GO:0071269',\n",
       " 'GO:0006535',\n",
       " 'GO:0009090',\n",
       " 'GO:0070179',\n",
       " 'GO:0019264',\n",
       " 'GO:0009070',\n",
       " 'GO:0019344']"
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "descendants"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### rendering subtrees\n",
    "\n",
    "We use the good-old-fashioned Tree renderer\n",
    "\n",
    "(this doesn't scale well for latticey-subontologies)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "renderer = GraphRenderer.create('tree')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      ". GO:0009070 ! serine family amino acid biosynthetic process\n",
      " % GO:0006545 ! glycine biosynthetic process\n",
      "  % GO:0019264 ! glycine biosynthetic process from serine\n",
      "  % GO:0019265 ! glycine biosynthetic process, by transamination of glyoxylate\n",
      " % GO:0006564 ! L-serine biosynthetic process\n",
      " % GO:0019344 ! cysteine biosynthetic process\n",
      "  % GO:0006535 ! cysteine biosynthetic process from serine\n",
      "  % GO:0019343 ! cysteine biosynthetic process via cystathionine\n",
      "  % GO:0019345 ! cysteine biosynthetic process via S-sulfo-L-cysteine\n",
      "  < GO:0004124 ! cysteine synthase activity\n",
      " % GO:0009090 ! homoserine biosynthetic process\n",
      " % GO:0016260 ! selenocysteine biosynthetic process\n",
      " % GO:0070179 ! D-serine biosynthetic process\n",
      " % GO:0071269 ! L-homocysteine biosynthetic process\n",
      "\n",
      "\n"
     ]
    }
   ],
   "source": [
    "print(renderer.render_subgraph(ont, nodes=descendants))"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### summarizing annotations\n",
    "\n",
    "We write a short procedure to wrap calling Golr and returning a summary dict\n",
    "\n",
    "The dict is keyed by taxon label. We also include an entry for `ALL`\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 58,
   "metadata": {},
   "outputs": [],
   "source": [
    "DEFAULT_FACET_FIELDS = ['taxon_subset_closure_label', 'evidence_label', 'assigned_by']\n",
    "def summarize(t: str, \n",
    "              evidence_closure='ECO:0000269', ## restrict to experimental\n",
    "              facet_fields=None) -> dict:\n",
    "    \"\"\"\n",
    "    Summarize a term\n",
    "    \"\"\"\n",
    "    if facet_fields == None:\n",
    "        facet_fields  = DEFAULT_FACET_FIELDS\n",
    "    q = GolrAssociationQuery(object=t, rows=0, object_category='function', \n",
    "                             fq={'evidence_closur'taxon_subset_closure_label'e_label':'experimental evidence'},\n",
    "                             facet_fields=facet_fields)\n",
    "    #params = q.solr_params()\n",
    "    #print(params)\n",
    "    result = q.exec()\n",
    "    fc = result['facet_counts']\n",
    "    item = {'ALL': result['numFound']}  ## make sure this is the first entry\n",
    "    for ff in facet_fields:\n",
    "        if ff in fc:\n",
    "            item.update(fc[ff])\n",
    "    return item"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 59,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'ALL': 144, 'Eukaryota': 92, 'Bacteria': 52, 'Metazoa': 33, 'Fungi': 32, 'Escherichia coli K-12': 27, 'Viridiplantae': 23, 'Mammalia': 22, 'Vertebrata <vertebrates>': 22, 'Arabidopsis thaliana': 21, 'Saccharomyces cerevisiae S288C': 17, 'Mycobacterium tuberculosis H37Rv': 11, 'Schizosaccharomyces pombe': 11, 'Homo sapiens': 8, 'Caenorhabditis elegans': 7, 'Mus musculus': 7, 'Rattus norvegicus': 7, 'Bacillus subtilis subsp. subtilis str. 168': 6, 'Pseudomonas aeruginosa PAO1': 4, 'Aspergillus nidulans FGSC A4': 3, 'Apis mellifera': 2, 'Leishmania major strain Friedlin': 2, 'Bombyx mori': 1, 'Candida albicans SC5314': 1, 'Dictyostelium discoideum': 1, 'Drosophila melanogaster': 1, 'direct assay evidence used in manual assertion': 81, 'mutant phenotype evidence used in manual assertion': 53, 'genetic interaction evidence used in manual assertion': 10, 'EcoCyc': 20, 'TAIR': 19, 'SGD': 17, 'UniProt': 16, 'PomBase': 11, 'MTBBASE': 10, 'EcoliWiki': 7, 'RGD': 7, 'WB': 7, 'MGI': 6, 'CAFA': 5, 'PseudoCAP': 5, 'BHF-UCL': 4, 'AspGD': 3, 'GeneDB': 3, 'CGD': 1, 'FlyBase': 1, 'GOC': 1, 'dictyBase': 1}\n"
     ]
    }
   ],
   "source": [
    "print(summarize(term_id))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 63,
   "metadata": {},
   "outputs": [],
   "source": [
    "def summarize_set(ids, facet_fields=None) -> pd.DataFrame:\n",
    "    \"\"\"\n",
    "    Summarize a set of annotations, return a dataframe\n",
    "    \"\"\"\n",
    "    items = []\n",
    "    for id in ids:\n",
    "        item = {'id': id, 'name:': ont.label(id)}\n",
    "        for k,v in summarize(id, facet_fields=facet_fields).items():\n",
    "            item[k] = v\n",
    "        items.append(item)\n",
    "    df =  pd.DataFrame(items).fillna(0)\n",
    "    # sort using total number\n",
    "    df.sort_values('ALL', axis=0, ascending=False, inplace=True)\n",
    "    return df"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Summarize GO term and descendants\n",
    "\n",
    "More advanced visualziations are easy with plotly etc. We leave as an exercise to the reader...\n",
    "\n",
    "As an example, for the first query we bundle all facets (species, evidence, assigned by) together"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 64,
   "metadata": {},
   "outputs": [
    {
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       "\n",
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       "    }\n",
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       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>id</th>\n",
       "      <th>name:</th>\n",
       "      <th>ALL</th>\n",
       "      <th>Bacteria</th>\n",
       "      <th>Escherichia coli K-12</th>\n",
       "      <th>Eukaryota</th>\n",
       "      <th>Mammalia</th>\n",
       "      <th>Metazoa</th>\n",
       "      <th>Mus musculus</th>\n",
       "      <th>Trypanosoma brucei brucei TREU927</th>\n",
       "      <th>Vertebrata &lt;vertebrates&gt;</th>\n",
       "      <th>mutant phenotype evidence used in manual assertion</th>\n",
       "      <th>direct assay evidence used in manual assertion</th>\n",
       "      <th>EcoCyc</th>\n",
       "      <th>GeneDB</th>\n",
       "      <th>MGI</th>\n",
       "      <th>Viridiplantae</th>\n",
       "      <th>Arabidopsis thaliana</th>\n",
       "      <th>Fungi</th>\n",
       "      <th>Caenorhabditis elegans</th>\n",
       "      <th>Schizosaccharomyces pombe</th>\n",
       "      <th>Bacillus subtilis subsp. subtilis str. 168</th>\n",
       "      <th>Mycobacterium tuberculosis H37Rv</th>\n",
       "      <th>Saccharomyces cerevisiae S288C</th>\n",
       "      <th>Solanum tuberosum</th>\n",
       "      <th>Spinacia oleracea</th>\n",
       "      <th>Streptomyces lavendulae</th>\n",
       "      <th>genetic interaction evidence used in manual assertion</th>\n",
       "      <th>TAIR</th>\n",
       "      <th>PomBase</th>\n",
       "      <th>UniProt</th>\n",
       "      <th>WB</th>\n",
       "      <th>CAFA</th>\n",
       "      <th>EcoliWiki</th>\n",
       "      <th>MTBBASE</th>\n",
       "      <th>SGD</th>\n",
       "      <th>Aspergillus nidulans FGSC A4</th>\n",
       "      <th>Apis mellifera</th>\n",
       "      <th>Homo sapiens</th>\n",
       "      <th>Leishmania major strain Friedlin</th>\n",
       "      <th>AspGD</th>\n",
       "      <th>BHF-UCL</th>\n",
       "      <th>Rattus norvegicus</th>\n",
       "      <th>RGD</th>\n",
       "      <th>Pseudomonas aeruginosa PAO1</th>\n",
       "      <th>Thermus thermophilus HB27</th>\n",
       "      <th>PseudoCAP</th>\n",
       "      <th>Bombyx mori</th>\n",
       "      <th>Drosophila melanogaster</th>\n",
       "      <th>FlyBase</th>\n",
       "      <th>Lactobacillus casei</th>\n",
       "      <th>Candida albicans SC5314</th>\n",
       "      <th>CGD</th>\n",
       "      <th>Dictyostelium discoideum</th>\n",
       "      <th>dictyBase</th>\n",
       "      <th>GOC</th>\n",
       "      <th>Pseudomonas aeruginosa</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>GO:0009070</td>\n",
       "      <td>serine family amino acid biosynthetic process</td>\n",
       "      <td>144</td>\n",
       "      <td>52.0</td>\n",
       "      <td>27.0</td>\n",
       "      <td>92.0</td>\n",
       "      <td>22.0</td>\n",
       "      <td>33.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>22.0</td>\n",
       "      <td>53.0</td>\n",
       "      <td>81.0</td>\n",
       "      <td>20.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>23.0</td>\n",
       "      <td>21.0</td>\n",
       "      <td>32.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>17.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>19.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>16.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>17.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>GO:0019344</td>\n",
       "      <td>cysteine biosynthetic process</td>\n",
       "      <td>82</td>\n",
       "      <td>25.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>57.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>15.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>30.0</td>\n",
       "      <td>49.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>21.0</td>\n",
       "      <td>19.0</td>\n",
       "      <td>19.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>17.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GO:0004124</td>\n",
       "      <td>cysteine synthase activity</td>\n",
       "      <td>29</td>\n",
       "      <td>7.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>22.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>21.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>13.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>GO:0006564</td>\n",
       "      <td>L-serine biosynthetic process</td>\n",
       "      <td>21</td>\n",
       "      <td>16.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>9.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>GO:0006535</td>\n",
       "      <td>cysteine biosynthetic process from serine</td>\n",
       "      <td>20</td>\n",
       "      <td>9.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>13.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>GO:0006545</td>\n",
       "      <td>glycine biosynthetic process</td>\n",
       "      <td>14</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>9.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GO:0019343</td>\n",
       "      <td>cysteine biosynthetic process via cystathionine</td>\n",
       "      <td>9</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>GO:0009090</td>\n",
       "      <td>homoserine biosynthetic process</td>\n",
       "      <td>8</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>GO:0070179</td>\n",
       "      <td>D-serine biosynthetic process</td>\n",
       "      <td>8</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GO:0016260</td>\n",
       "      <td>selenocysteine biosynthetic process</td>\n",
       "      <td>6</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>GO:0019264</td>\n",
       "      <td>glycine biosynthetic process from serine</td>\n",
       "      <td>6</td>\n",
       "      <td>2.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GO:0019265</td>\n",
       "      <td>glycine biosynthetic process, by transaminatio...</td>\n",
       "      <td>4</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>GO:0071269</td>\n",
       "      <td>L-homocysteine biosynthetic process</td>\n",
       "      <td>1</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GO:0019345</td>\n",
       "      <td>cysteine biosynthetic process via S-sulfo-L-cy...</td>\n",
       "      <td>0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "            id                                              name:  ALL  \\\n",
       "12  GO:0009070      serine family amino acid biosynthetic process  144   \n",
       "13  GO:0019344                      cysteine biosynthetic process   82   \n",
       "1   GO:0004124                         cysteine synthase activity   29   \n",
       "5   GO:0006564                      L-serine biosynthetic process   21   \n",
       "8   GO:0006535          cysteine biosynthetic process from serine   20   \n",
       "6   GO:0006545                       glycine biosynthetic process   14   \n",
       "2   GO:0019343    cysteine biosynthetic process via cystathionine    9   \n",
       "9   GO:0009090                    homoserine biosynthetic process    8   \n",
       "10  GO:0070179                      D-serine biosynthetic process    8   \n",
       "0   GO:0016260                selenocysteine biosynthetic process    6   \n",
       "11  GO:0019264           glycine biosynthetic process from serine    6   \n",
       "3   GO:0019265  glycine biosynthetic process, by transaminatio...    4   \n",
       "7   GO:0071269                L-homocysteine biosynthetic process    1   \n",
       "4   GO:0019345  cysteine biosynthetic process via S-sulfo-L-cy...    0   \n",
       "\n",
       "    Bacteria  Escherichia coli K-12  Eukaryota  Mammalia  Metazoa  \\\n",
       "12      52.0                   27.0       92.0      22.0     33.0   \n",
       "13      25.0                    8.0       57.0       6.0     15.0   \n",
       "1        7.0                    3.0       22.0       0.0      4.0   \n",
       "5       16.0                    8.0        5.0       1.0      1.0   \n",
       "8        9.0                    4.0       11.0       0.0      4.0   \n",
       "6        3.0                    3.0       11.0       7.0      9.0   \n",
       "2        1.0                    0.0        8.0       1.0      2.0   \n",
       "9        4.0                    4.0        4.0       0.0      0.0   \n",
       "10       0.0                    0.0        8.0       6.0      6.0   \n",
       "0        4.0                    4.0        2.0       1.0      1.0   \n",
       "11       2.0                    2.0        4.0       2.0      4.0   \n",
       "3        0.0                    0.0        4.0       3.0      3.0   \n",
       "7        0.0                    0.0        1.0       0.0      0.0   \n",
       "4        0.0                    0.0        0.0       0.0      0.0   \n",
       "\n",
       "    Mus musculus  Trypanosoma brucei brucei TREU927  Vertebrata <vertebrates>  \\\n",
       "12           7.0                                0.0                      22.0   \n",
       "13           2.0                                0.0                       6.0   \n",
       "1            0.0                                0.0                       0.0   \n",
       "5            0.0                                0.0                       1.0   \n",
       "8            0.0                                0.0                       0.0   \n",
       "6            0.0                                0.0                       7.0   \n",
       "2            0.0                                0.0                       1.0   \n",
       "9            0.0                                0.0                       0.0   \n",
       "10           4.0                                0.0                       6.0   \n",
       "0            1.0                                1.0                       1.0   \n",
       "11           0.0                                0.0                       2.0   \n",
       "3            0.0                                0.0                       3.0   \n",
       "7            0.0                                0.0                       0.0   \n",
       "4            0.0                                0.0                       0.0   \n",
       "\n",
       "    mutant phenotype evidence used in manual assertion  \\\n",
       "12                                               53.0    \n",
       "13                                               30.0    \n",
       "1                                                 6.0    \n",
       "5                                                 9.0    \n",
       "8                                                 6.0    \n",
       "6                                                 2.0    \n",
       "2                                                 6.0    \n",
       "9                                                 4.0    \n",
       "10                                                0.0    \n",
       "0                                                 4.0    \n",
       "11                                                2.0    \n",
       "3                                                 0.0    \n",
       "7                                                 0.0    \n",
       "4                                                 0.0    \n",
       "\n",
       "    direct assay evidence used in manual assertion  EcoCyc  GeneDB  MGI  \\\n",
       "12                                            81.0    20.0     3.0  6.0   \n",
       "13                                            49.0     6.0     2.0  1.0   \n",
       "1                                             21.0     2.0     0.0  0.0   \n",
       "5                                              6.0     3.0     0.0  0.0   \n",
       "8                                             13.0     3.0     1.0  0.0   \n",
       "6                                             11.0     3.0     0.0  0.0   \n",
       "2                                              3.0     0.0     1.0  0.0   \n",
       "9                                              4.0     4.0     0.0  0.0   \n",
       "10                                             8.0     0.0     0.0  4.0   \n",
       "0                                              2.0     4.0     1.0  1.0   \n",
       "11                                             4.0     2.0     0.0  0.0   \n",
       "3                                              4.0     0.0     0.0  0.0   \n",
       "7                                              1.0     0.0     0.0  0.0   \n",
       "4                                              0.0     0.0     0.0  0.0   \n",
       "\n",
       "    Viridiplantae  Arabidopsis thaliana  Fungi  Caenorhabditis elegans  \\\n",
       "12           23.0                  21.0   32.0                     7.0   \n",
       "13           21.0                  19.0   19.0                     7.0   \n",
       "1            13.0                  11.0    5.0                     4.0   \n",
       "5             1.0                   1.0    3.0                     0.0   \n",
       "8             0.0                   0.0    6.0                     3.0   \n",
       "6             0.0                   0.0    2.0                     0.0   \n",
       "2             0.0                   0.0    5.0                     0.0   \n",
       "9             0.0                   0.0    4.0                     0.0   \n",
       "10            1.0                   1.0    0.0                     0.0   \n",
       "0             0.0                   0.0    0.0                     0.0   \n",
       "11            0.0                   0.0    0.0                     0.0   \n",
       "3             0.0                   0.0    1.0                     0.0   \n",
       "7             0.0                   0.0    1.0                     0.0   \n",
       "4             0.0                   0.0    0.0                     0.0   \n",
       "\n",
       "    Schizosaccharomyces pombe  Bacillus subtilis subsp. subtilis str. 168  \\\n",
       "12                       11.0                                         6.0   \n",
       "13                       10.0                                         5.0   \n",
       "1                         4.0                                         2.0   \n",
       "5                         0.0                                         1.0   \n",
       "8                         5.0                                         2.0   \n",
       "6                         0.0                                         0.0   \n",
       "2                         0.0                                         0.0   \n",
       "9                         0.0                                         0.0   \n",
       "10                        0.0                                         0.0   \n",
       "0                         0.0                                         0.0   \n",
       "11                        0.0                                         0.0   \n",
       "3                         0.0                                         0.0   \n",
       "7                         1.0                                         0.0   \n",
       "4                         0.0                                         0.0   \n",
       "\n",
       "    Mycobacterium tuberculosis H37Rv  Saccharomyces cerevisiae S288C  \\\n",
       "12                              11.0                            17.0   \n",
       "13                               8.0                             6.0   \n",
       "1                                1.0                             1.0   \n",
       "5                                3.0                             3.0   \n",
       "8                                2.0                             1.0   \n",
       "6                                0.0                             2.0   \n",
       "2                                1.0                             3.0   \n",
       "9                                0.0                             3.0   \n",
       "10                               0.0                             0.0   \n",
       "0                                0.0                             0.0   \n",
       "11                               0.0                             0.0   \n",
       "3                                0.0                             1.0   \n",
       "7                                0.0                             0.0   \n",
       "4                                0.0                             0.0   \n",
       "\n",
       "    Solanum tuberosum  Spinacia oleracea  Streptomyces lavendulae  \\\n",
       "12                0.0                0.0                      0.0   \n",
       "13                1.0                1.0                      0.0   \n",
       "1                 1.0                1.0                      1.0   \n",
       "5                 0.0                0.0                      0.0   \n",
       "8                 0.0                0.0                      0.0   \n",
       "6                 0.0                0.0                      0.0   \n",
       "2                 0.0                0.0                      0.0   \n",
       "9                 0.0                0.0                      0.0   \n",
       "10                0.0                0.0                      0.0   \n",
       "0                 0.0                0.0                      0.0   \n",
       "11                0.0                0.0                      0.0   \n",
       "3                 0.0                0.0                      0.0   \n",
       "7                 0.0                0.0                      0.0   \n",
       "4                 0.0                0.0                      0.0   \n",
       "\n",
       "    genetic interaction evidence used in manual assertion  TAIR  PomBase  \\\n",
       "12                                               10.0      19.0     11.0   \n",
       "13                                                3.0      17.0     10.0   \n",
       "1                                                 2.0      10.0      4.0   \n",
       "5                                                 6.0       1.0      0.0   \n",
       "8                                                 1.0       0.0      5.0   \n",
       "6                                                 1.0       0.0      0.0   \n",
       "2                                                 0.0       0.0      0.0   \n",
       "9                                                 0.0       0.0      0.0   \n",
       "10                                                0.0       1.0      0.0   \n",
       "0                                                 0.0       0.0      0.0   \n",
       "11                                                0.0       0.0      0.0   \n",
       "3                                                 0.0       0.0      0.0   \n",
       "7                                                 0.0       0.0      1.0   \n",
       "4                                                 0.0       0.0      0.0   \n",
       "\n",
       "    UniProt   WB  CAFA  EcoliWiki  MTBBASE   SGD  \\\n",
       "12     16.0  7.0   5.0        7.0     10.0  17.0   \n",
       "13     10.0  7.0   5.0        2.0      7.0   6.0   \n",
       "1       4.0  4.0   2.0        1.0      1.0   1.0   \n",
       "5       2.0  0.0   0.0        5.0      3.0   3.0   \n",
       "8       2.0  3.0   2.0        1.0      2.0   1.0   \n",
       "6       2.0  0.0   0.0        0.0      0.0   2.0   \n",
       "2       1.0  0.0   0.0        0.0      1.0   3.0   \n",
       "9       0.0  0.0   0.0        0.0      0.0   3.0   \n",
       "10      2.0  0.0   0.0        0.0      0.0   0.0   \n",
       "0       0.0  0.0   0.0        0.0      0.0   0.0   \n",
       "11      1.0  0.0   0.0        0.0      0.0   0.0   \n",
       "3       1.0  0.0   0.0        0.0      0.0   1.0   \n",
       "7       0.0  0.0   0.0        0.0      0.0   0.0   \n",
       "4       0.0  0.0   0.0        0.0      0.0   0.0   \n",
       "\n",
       "    Aspergillus nidulans FGSC A4  Apis mellifera  Homo sapiens  \\\n",
       "12                           3.0             2.0           8.0   \n",
       "13                           3.0             2.0           3.0   \n",
       "1                            0.0             0.0           0.0   \n",
       "5                            0.0             0.0           0.0   \n",
       "8                            0.0             1.0           0.0   \n",
       "6                            0.0             0.0           2.0   \n",
       "2                            2.0             1.0           1.0   \n",
       "9                            0.0             0.0           0.0   \n",
       "10                           0.0             0.0           2.0   \n",
       "0                            0.0             0.0           0.0   \n",
       "11                           0.0             0.0           0.0   \n",
       "3                            0.0             0.0           2.0   \n",
       "7                            0.0             0.0           0.0   \n",
       "4                            0.0             0.0           0.0   \n",
       "\n",
       "    Leishmania major strain Friedlin  AspGD  BHF-UCL  Rattus norvegicus  RGD  \\\n",
       "12                               2.0    3.0      4.0                7.0  7.0   \n",
       "13                               2.0    3.0      2.0                1.0  1.0   \n",
       "1                                0.0    0.0      0.0                0.0  0.0   \n",
       "5                                0.0    0.0      0.0                1.0  1.0   \n",
       "8                                1.0    0.0      0.0                0.0  0.0   \n",
       "6                                0.0    0.0      1.0                5.0  5.0   \n",
       "2                                1.0    2.0      1.0                0.0  0.0   \n",
       "9                                0.0    0.0      0.0                0.0  0.0   \n",
       "10                               0.0    0.0      0.0                0.0  0.0   \n",
       "0                                0.0    0.0      0.0                0.0  0.0   \n",
       "11                               0.0    0.0      0.0                2.0  2.0   \n",
       "3                                0.0    0.0      1.0                1.0  1.0   \n",
       "7                                0.0    0.0      0.0                0.0  0.0   \n",
       "4                                0.0    0.0      0.0                0.0  0.0   \n",
       "\n",
       "    Pseudomonas aeruginosa PAO1  Thermus thermophilus HB27  PseudoCAP  \\\n",
       "12                          4.0                        0.0        5.0   \n",
       "13                          1.0                        0.0        2.0   \n",
       "1                           0.0                        0.0        0.0   \n",
       "5                           3.0                        1.0        3.0   \n",
       "8                           0.0                        0.0        0.0   \n",
       "6                           0.0                        0.0        0.0   \n",
       "2                           0.0                        0.0        0.0   \n",
       "9                           0.0                        0.0        0.0   \n",
       "10                          0.0                        0.0        0.0   \n",
       "0                           0.0                        0.0        0.0   \n",
       "11                          0.0                        0.0        0.0   \n",
       "3                           0.0                        0.0        0.0   \n",
       "7                           0.0                        0.0        0.0   \n",
       "4                           0.0                        0.0        0.0   \n",
       "\n",
       "    Bombyx mori  Drosophila melanogaster  FlyBase  Lactobacillus casei  \\\n",
       "12          1.0                      1.0      1.0                  0.0   \n",
       "13          0.0                      0.0      0.0                  1.0   \n",
       "1           0.0                      0.0      0.0                  0.0   \n",
       "5           0.0                      0.0      0.0                  0.0   \n",
       "8           0.0                      0.0      0.0                  1.0   \n",
       "6           1.0                      1.0      1.0                  0.0   \n",
       "2           0.0                      0.0      0.0                  0.0   \n",
       "9           0.0                      0.0      0.0                  0.0   \n",
       "10          0.0                      0.0      0.0                  0.0   \n",
       "0           0.0                      0.0      0.0                  0.0   \n",
       "11          1.0                      1.0      1.0                  0.0   \n",
       "3           0.0                      0.0      0.0                  0.0   \n",
       "7           0.0                      0.0      0.0                  0.0   \n",
       "4           0.0                      0.0      0.0                  0.0   \n",
       "\n",
       "    Candida albicans SC5314  CGD  Dictyostelium discoideum  dictyBase  GOC  \\\n",
       "12                      1.0  1.0                       1.0        1.0  1.0   \n",
       "13                      0.0  0.0                       0.0        0.0  1.0   \n",
       "1                       0.0  0.0                       0.0        0.0  0.0   \n",
       "5                       0.0  0.0                       0.0        0.0  0.0   \n",
       "8                       0.0  0.0                       0.0        0.0  0.0   \n",
       "6                       0.0  0.0                       0.0        0.0  0.0   \n",
       "2                       0.0  0.0                       0.0        0.0  0.0   \n",
       "9                       1.0  1.0                       0.0        0.0  0.0   \n",
       "10                      0.0  0.0                       1.0        1.0  0.0   \n",
       "0                       0.0  0.0                       0.0        0.0  0.0   \n",
       "11                      0.0  0.0                       0.0        0.0  0.0   \n",
       "3                       0.0  0.0                       0.0        0.0  0.0   \n",
       "7                       0.0  0.0                       0.0        0.0  0.0   \n",
       "4                       0.0  0.0                       0.0        0.0  0.0   \n",
       "\n",
       "    Pseudomonas aeruginosa  \n",
       "12                     0.0  \n",
       "13                     1.0  \n",
       "1                      0.0  \n",
       "5                      0.0  \n",
       "8                      0.0  \n",
       "6                      0.0  \n",
       "2                      0.0  \n",
       "9                      0.0  \n",
       "10                     0.0  \n",
       "0                      0.0  \n",
       "11                     0.0  \n",
       "3                      0.0  \n",
       "7                      0.0  \n",
       "4                      0.0  "
      ]
     },
     "execution_count": 64,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "pd.options.display.max_columns = None\n",
    "df = summarize_set(descendants)\n",
    "df"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Summary by assigned by\n",
    "\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 67,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "      <th></th>\n",
       "      <th>id</th>\n",
       "      <th>name:</th>\n",
       "      <th>ALL</th>\n",
       "      <th>EcoCyc</th>\n",
       "      <th>GeneDB</th>\n",
       "      <th>MGI</th>\n",
       "      <th>TAIR</th>\n",
       "      <th>PomBase</th>\n",
       "      <th>UniProt</th>\n",
       "      <th>WB</th>\n",
       "      <th>CAFA</th>\n",
       "      <th>EcoliWiki</th>\n",
       "      <th>MTBBASE</th>\n",
       "      <th>SGD</th>\n",
       "      <th>AspGD</th>\n",
       "      <th>BHF-UCL</th>\n",
       "      <th>RGD</th>\n",
       "      <th>PseudoCAP</th>\n",
       "      <th>FlyBase</th>\n",
       "      <th>CGD</th>\n",
       "      <th>dictyBase</th>\n",
       "      <th>GOC</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>GO:0009070</td>\n",
       "      <td>serine family amino acid biosynthetic process</td>\n",
       "      <td>144</td>\n",
       "      <td>20.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>19.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>16.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>17.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>GO:0019344</td>\n",
       "      <td>cysteine biosynthetic process</td>\n",
       "      <td>82</td>\n",
       "      <td>6.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>17.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GO:0004124</td>\n",
       "      <td>cysteine synthase activity</td>\n",
       "      <td>29</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>GO:0006564</td>\n",
       "      <td>L-serine biosynthetic process</td>\n",
       "      <td>21</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>GO:0006535</td>\n",
       "      <td>cysteine biosynthetic process from serine</td>\n",
       "      <td>20</td>\n",
       "      <td>3.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>GO:0006545</td>\n",
       "      <td>glycine biosynthetic process</td>\n",
       "      <td>14</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GO:0019343</td>\n",
       "      <td>cysteine biosynthetic process via cystathionine</td>\n",
       "      <td>9</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>GO:0009090</td>\n",
       "      <td>homoserine biosynthetic process</td>\n",
       "      <td>8</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>GO:0070179</td>\n",
       "      <td>D-serine biosynthetic process</td>\n",
       "      <td>8</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GO:0016260</td>\n",
       "      <td>selenocysteine biosynthetic process</td>\n",
       "      <td>6</td>\n",
       "      <td>4.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>GO:0019264</td>\n",
       "      <td>glycine biosynthetic process from serine</td>\n",
       "      <td>6</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GO:0019265</td>\n",
       "      <td>glycine biosynthetic process, by transaminatio...</td>\n",
       "      <td>4</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>GO:0071269</td>\n",
       "      <td>L-homocysteine biosynthetic process</td>\n",
       "      <td>1</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GO:0019345</td>\n",
       "      <td>cysteine biosynthetic process via S-sulfo-L-cy...</td>\n",
       "      <td>0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "            id                                              name:  ALL  \\\n",
       "12  GO:0009070      serine family amino acid biosynthetic process  144   \n",
       "13  GO:0019344                      cysteine biosynthetic process   82   \n",
       "1   GO:0004124                         cysteine synthase activity   29   \n",
       "5   GO:0006564                      L-serine biosynthetic process   21   \n",
       "8   GO:0006535          cysteine biosynthetic process from serine   20   \n",
       "6   GO:0006545                       glycine biosynthetic process   14   \n",
       "2   GO:0019343    cysteine biosynthetic process via cystathionine    9   \n",
       "9   GO:0009090                    homoserine biosynthetic process    8   \n",
       "10  GO:0070179                      D-serine biosynthetic process    8   \n",
       "0   GO:0016260                selenocysteine biosynthetic process    6   \n",
       "11  GO:0019264           glycine biosynthetic process from serine    6   \n",
       "3   GO:0019265  glycine biosynthetic process, by transaminatio...    4   \n",
       "7   GO:0071269                L-homocysteine biosynthetic process    1   \n",
       "4   GO:0019345  cysteine biosynthetic process via S-sulfo-L-cy...    0   \n",
       "\n",
       "    EcoCyc  GeneDB  MGI  TAIR  PomBase  UniProt   WB  CAFA  EcoliWiki  \\\n",
       "12    20.0     3.0  6.0  19.0     11.0     16.0  7.0   5.0        7.0   \n",
       "13     6.0     2.0  1.0  17.0     10.0     10.0  7.0   5.0        2.0   \n",
       "1      2.0     0.0  0.0  10.0      4.0      4.0  4.0   2.0        1.0   \n",
       "5      3.0     0.0  0.0   1.0      0.0      2.0  0.0   0.0        5.0   \n",
       "8      3.0     1.0  0.0   0.0      5.0      2.0  3.0   2.0        1.0   \n",
       "6      3.0     0.0  0.0   0.0      0.0      2.0  0.0   0.0        0.0   \n",
       "2      0.0     1.0  0.0   0.0      0.0      1.0  0.0   0.0        0.0   \n",
       "9      4.0     0.0  0.0   0.0      0.0      0.0  0.0   0.0        0.0   \n",
       "10     0.0     0.0  4.0   1.0      0.0      2.0  0.0   0.0        0.0   \n",
       "0      4.0     1.0  1.0   0.0      0.0      0.0  0.0   0.0        0.0   \n",
       "11     2.0     0.0  0.0   0.0      0.0      1.0  0.0   0.0        0.0   \n",
       "3      0.0     0.0  0.0   0.0      0.0      1.0  0.0   0.0        0.0   \n",
       "7      0.0     0.0  0.0   0.0      1.0      0.0  0.0   0.0        0.0   \n",
       "4      0.0     0.0  0.0   0.0      0.0      0.0  0.0   0.0        0.0   \n",
       "\n",
       "    MTBBASE   SGD  AspGD  BHF-UCL  RGD  PseudoCAP  FlyBase  CGD  dictyBase  \\\n",
       "12     10.0  17.0    3.0      4.0  7.0        5.0      1.0  1.0        1.0   \n",
       "13      7.0   6.0    3.0      2.0  1.0        2.0      0.0  0.0        0.0   \n",
       "1       1.0   1.0    0.0      0.0  0.0        0.0      0.0  0.0        0.0   \n",
       "5       3.0   3.0    0.0      0.0  1.0        3.0      0.0  0.0        0.0   \n",
       "8       2.0   1.0    0.0      0.0  0.0        0.0      0.0  0.0        0.0   \n",
       "6       0.0   2.0    0.0      1.0  5.0        0.0      1.0  0.0        0.0   \n",
       "2       1.0   3.0    2.0      1.0  0.0        0.0      0.0  0.0        0.0   \n",
       "9       0.0   3.0    0.0      0.0  0.0        0.0      0.0  1.0        0.0   \n",
       "10      0.0   0.0    0.0      0.0  0.0        0.0      0.0  0.0        1.0   \n",
       "0       0.0   0.0    0.0      0.0  0.0        0.0      0.0  0.0        0.0   \n",
       "11      0.0   0.0    0.0      0.0  2.0        0.0      1.0  0.0        0.0   \n",
       "3       0.0   1.0    0.0      1.0  1.0        0.0      0.0  0.0        0.0   \n",
       "7       0.0   0.0    0.0      0.0  0.0        0.0      0.0  0.0        0.0   \n",
       "4       0.0   0.0    0.0      0.0  0.0        0.0      0.0  0.0        0.0   \n",
       "\n",
       "    GOC  \n",
       "12  1.0  \n",
       "13  1.0  \n",
       "1   0.0  \n",
       "5   0.0  \n",
       "8   0.0  \n",
       "6   0.0  \n",
       "2   0.0  \n",
       "9   0.0  \n",
       "10  0.0  \n",
       "0   0.0  \n",
       "11  0.0  \n",
       "3   0.0  \n",
       "7   0.0  \n",
       "4   0.0  "
      ]
     },
     "execution_count": 67,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "summarize_set(descendants, facet_fields=['assigned_by'])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Summarize by species\n",
    "\n",
    "use `taxon_subset_closure_label` facet"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 69,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "      <th></th>\n",
       "      <th>id</th>\n",
       "      <th>name:</th>\n",
       "      <th>ALL</th>\n",
       "      <th>Bacteria</th>\n",
       "      <th>Escherichia coli K-12</th>\n",
       "      <th>Eukaryota</th>\n",
       "      <th>Mammalia</th>\n",
       "      <th>Metazoa</th>\n",
       "      <th>Mus musculus</th>\n",
       "      <th>Trypanosoma brucei brucei TREU927</th>\n",
       "      <th>Vertebrata &lt;vertebrates&gt;</th>\n",
       "      <th>Viridiplantae</th>\n",
       "      <th>Arabidopsis thaliana</th>\n",
       "      <th>Fungi</th>\n",
       "      <th>Caenorhabditis elegans</th>\n",
       "      <th>Schizosaccharomyces pombe</th>\n",
       "      <th>Bacillus subtilis subsp. subtilis str. 168</th>\n",
       "      <th>Mycobacterium tuberculosis H37Rv</th>\n",
       "      <th>Saccharomyces cerevisiae S288C</th>\n",
       "      <th>Solanum tuberosum</th>\n",
       "      <th>Spinacia oleracea</th>\n",
       "      <th>Streptomyces lavendulae</th>\n",
       "      <th>Aspergillus nidulans FGSC A4</th>\n",
       "      <th>Apis mellifera</th>\n",
       "      <th>Homo sapiens</th>\n",
       "      <th>Leishmania major strain Friedlin</th>\n",
       "      <th>Rattus norvegicus</th>\n",
       "      <th>Pseudomonas aeruginosa PAO1</th>\n",
       "      <th>Thermus thermophilus HB27</th>\n",
       "      <th>Bombyx mori</th>\n",
       "      <th>Drosophila melanogaster</th>\n",
       "      <th>Lactobacillus casei</th>\n",
       "      <th>Candida albicans SC5314</th>\n",
       "      <th>Dictyostelium discoideum</th>\n",
       "      <th>Pseudomonas aeruginosa</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>GO:0009070</td>\n",
       "      <td>serine family amino acid biosynthetic process</td>\n",
       "      <td>144</td>\n",
       "      <td>52.0</td>\n",
       "      <td>27.0</td>\n",
       "      <td>92.0</td>\n",
       "      <td>22.0</td>\n",
       "      <td>33.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>22.0</td>\n",
       "      <td>23.0</td>\n",
       "      <td>21.0</td>\n",
       "      <td>32.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>17.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>GO:0019344</td>\n",
       "      <td>cysteine biosynthetic process</td>\n",
       "      <td>82</td>\n",
       "      <td>25.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>57.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>15.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>21.0</td>\n",
       "      <td>19.0</td>\n",
       "      <td>19.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>10.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GO:0004124</td>\n",
       "      <td>cysteine synthase activity</td>\n",
       "      <td>29</td>\n",
       "      <td>7.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>22.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>13.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>GO:0006564</td>\n",
       "      <td>L-serine biosynthetic process</td>\n",
       "      <td>21</td>\n",
       "      <td>16.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>GO:0006535</td>\n",
       "      <td>cysteine biosynthetic process from serine</td>\n",
       "      <td>20</td>\n",
       "      <td>9.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>GO:0006545</td>\n",
       "      <td>glycine biosynthetic process</td>\n",
       "      <td>14</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>11.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>9.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>7.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GO:0019343</td>\n",
       "      <td>cysteine biosynthetic process via cystathionine</td>\n",
       "      <td>9</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>5.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>GO:0009090</td>\n",
       "      <td>homoserine biosynthetic process</td>\n",
       "      <td>8</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>GO:0070179</td>\n",
       "      <td>D-serine biosynthetic process</td>\n",
       "      <td>8</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>8.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>6.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GO:0016260</td>\n",
       "      <td>selenocysteine biosynthetic process</td>\n",
       "      <td>6</td>\n",
       "      <td>4.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>GO:0019264</td>\n",
       "      <td>glycine biosynthetic process from serine</td>\n",
       "      <td>6</td>\n",
       "      <td>2.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GO:0019265</td>\n",
       "      <td>glycine biosynthetic process, by transaminatio...</td>\n",
       "      <td>4</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>4.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>3.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>2.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>GO:0071269</td>\n",
       "      <td>L-homocysteine biosynthetic process</td>\n",
       "      <td>1</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>1.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GO:0019345</td>\n",
       "      <td>cysteine biosynthetic process via S-sulfo-L-cy...</td>\n",
       "      <td>0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "      <td>0.0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "            id                                              name:  ALL  \\\n",
       "12  GO:0009070      serine family amino acid biosynthetic process  144   \n",
       "13  GO:0019344                      cysteine biosynthetic process   82   \n",
       "1   GO:0004124                         cysteine synthase activity   29   \n",
       "5   GO:0006564                      L-serine biosynthetic process   21   \n",
       "8   GO:0006535          cysteine biosynthetic process from serine   20   \n",
       "6   GO:0006545                       glycine biosynthetic process   14   \n",
       "2   GO:0019343    cysteine biosynthetic process via cystathionine    9   \n",
       "9   GO:0009090                    homoserine biosynthetic process    8   \n",
       "10  GO:0070179                      D-serine biosynthetic process    8   \n",
       "0   GO:0016260                selenocysteine biosynthetic process    6   \n",
       "11  GO:0019264           glycine biosynthetic process from serine    6   \n",
       "3   GO:0019265  glycine biosynthetic process, by transaminatio...    4   \n",
       "7   GO:0071269                L-homocysteine biosynthetic process    1   \n",
       "4   GO:0019345  cysteine biosynthetic process via S-sulfo-L-cy...    0   \n",
       "\n",
       "    Bacteria  Escherichia coli K-12  Eukaryota  Mammalia  Metazoa  \\\n",
       "12      52.0                   27.0       92.0      22.0     33.0   \n",
       "13      25.0                    8.0       57.0       6.0     15.0   \n",
       "1        7.0                    3.0       22.0       0.0      4.0   \n",
       "5       16.0                    8.0        5.0       1.0      1.0   \n",
       "8        9.0                    4.0       11.0       0.0      4.0   \n",
       "6        3.0                    3.0       11.0       7.0      9.0   \n",
       "2        1.0                    0.0        8.0       1.0      2.0   \n",
       "9        4.0                    4.0        4.0       0.0      0.0   \n",
       "10       0.0                    0.0        8.0       6.0      6.0   \n",
       "0        4.0                    4.0        2.0       1.0      1.0   \n",
       "11       2.0                    2.0        4.0       2.0      4.0   \n",
       "3        0.0                    0.0        4.0       3.0      3.0   \n",
       "7        0.0                    0.0        1.0       0.0      0.0   \n",
       "4        0.0                    0.0        0.0       0.0      0.0   \n",
       "\n",
       "    Mus musculus  Trypanosoma brucei brucei TREU927  Vertebrata <vertebrates>  \\\n",
       "12           7.0                                0.0                      22.0   \n",
       "13           2.0                                0.0                       6.0   \n",
       "1            0.0                                0.0                       0.0   \n",
       "5            0.0                                0.0                       1.0   \n",
       "8            0.0                                0.0                       0.0   \n",
       "6            0.0                                0.0                       7.0   \n",
       "2            0.0                                0.0                       1.0   \n",
       "9            0.0                                0.0                       0.0   \n",
       "10           4.0                                0.0                       6.0   \n",
       "0            1.0                                1.0                       1.0   \n",
       "11           0.0                                0.0                       2.0   \n",
       "3            0.0                                0.0                       3.0   \n",
       "7            0.0                                0.0                       0.0   \n",
       "4            0.0                                0.0                       0.0   \n",
       "\n",
       "    Viridiplantae  Arabidopsis thaliana  Fungi  Caenorhabditis elegans  \\\n",
       "12           23.0                  21.0   32.0                     7.0   \n",
       "13           21.0                  19.0   19.0                     7.0   \n",
       "1            13.0                  11.0    5.0                     4.0   \n",
       "5             1.0                   1.0    3.0                     0.0   \n",
       "8             0.0                   0.0    6.0                     3.0   \n",
       "6             0.0                   0.0    2.0                     0.0   \n",
       "2             0.0                   0.0    5.0                     0.0   \n",
       "9             0.0                   0.0    4.0                     0.0   \n",
       "10            1.0                   1.0    0.0                     0.0   \n",
       "0             0.0                   0.0    0.0                     0.0   \n",
       "11            0.0                   0.0    0.0                     0.0   \n",
       "3             0.0                   0.0    1.0                     0.0   \n",
       "7             0.0                   0.0    1.0                     0.0   \n",
       "4             0.0                   0.0    0.0                     0.0   \n",
       "\n",
       "    Schizosaccharomyces pombe  Bacillus subtilis subsp. subtilis str. 168  \\\n",
       "12                       11.0                                         6.0   \n",
       "13                       10.0                                         5.0   \n",
       "1                         4.0                                         2.0   \n",
       "5                         0.0                                         1.0   \n",
       "8                         5.0                                         2.0   \n",
       "6                         0.0                                         0.0   \n",
       "2                         0.0                                         0.0   \n",
       "9                         0.0                                         0.0   \n",
       "10                        0.0                                         0.0   \n",
       "0                         0.0                                         0.0   \n",
       "11                        0.0                                         0.0   \n",
       "3                         0.0                                         0.0   \n",
       "7                         1.0                                         0.0   \n",
       "4                         0.0                                         0.0   \n",
       "\n",
       "    Mycobacterium tuberculosis H37Rv  Saccharomyces cerevisiae S288C  \\\n",
       "12                              11.0                            17.0   \n",
       "13                               8.0                             6.0   \n",
       "1                                1.0                             1.0   \n",
       "5                                3.0                             3.0   \n",
       "8                                2.0                             1.0   \n",
       "6                                0.0                             2.0   \n",
       "2                                1.0                             3.0   \n",
       "9                                0.0                             3.0   \n",
       "10                               0.0                             0.0   \n",
       "0                                0.0                             0.0   \n",
       "11                               0.0                             0.0   \n",
       "3                                0.0                             1.0   \n",
       "7                                0.0                             0.0   \n",
       "4                                0.0                             0.0   \n",
       "\n",
       "    Solanum tuberosum  Spinacia oleracea  Streptomyces lavendulae  \\\n",
       "12                0.0                0.0                      0.0   \n",
       "13                1.0                1.0                      0.0   \n",
       "1                 1.0                1.0                      1.0   \n",
       "5                 0.0                0.0                      0.0   \n",
       "8                 0.0                0.0                      0.0   \n",
       "6                 0.0                0.0                      0.0   \n",
       "2                 0.0                0.0                      0.0   \n",
       "9                 0.0                0.0                      0.0   \n",
       "10                0.0                0.0                      0.0   \n",
       "0                 0.0                0.0                      0.0   \n",
       "11                0.0                0.0                      0.0   \n",
       "3                 0.0                0.0                      0.0   \n",
       "7                 0.0                0.0                      0.0   \n",
       "4                 0.0                0.0                      0.0   \n",
       "\n",
       "    Aspergillus nidulans FGSC A4  Apis mellifera  Homo sapiens  \\\n",
       "12                           3.0             2.0           8.0   \n",
       "13                           3.0             2.0           3.0   \n",
       "1                            0.0             0.0           0.0   \n",
       "5                            0.0             0.0           0.0   \n",
       "8                            0.0             1.0           0.0   \n",
       "6                            0.0             0.0           2.0   \n",
       "2                            2.0             1.0           1.0   \n",
       "9                            0.0             0.0           0.0   \n",
       "10                           0.0             0.0           2.0   \n",
       "0                            0.0             0.0           0.0   \n",
       "11                           0.0             0.0           0.0   \n",
       "3                            0.0             0.0           2.0   \n",
       "7                            0.0             0.0           0.0   \n",
       "4                            0.0             0.0           0.0   \n",
       "\n",
       "    Leishmania major strain Friedlin  Rattus norvegicus  \\\n",
       "12                               2.0                7.0   \n",
       "13                               2.0                1.0   \n",
       "1                                0.0                0.0   \n",
       "5                                0.0                1.0   \n",
       "8                                1.0                0.0   \n",
       "6                                0.0                5.0   \n",
       "2                                1.0                0.0   \n",
       "9                                0.0                0.0   \n",
       "10                               0.0                0.0   \n",
       "0                                0.0                0.0   \n",
       "11                               0.0                2.0   \n",
       "3                                0.0                1.0   \n",
       "7                                0.0                0.0   \n",
       "4                                0.0                0.0   \n",
       "\n",
       "    Pseudomonas aeruginosa PAO1  Thermus thermophilus HB27  Bombyx mori  \\\n",
       "12                          4.0                        0.0          1.0   \n",
       "13                          1.0                        0.0          0.0   \n",
       "1                           0.0                        0.0          0.0   \n",
       "5                           3.0                        1.0          0.0   \n",
       "8                           0.0                        0.0          0.0   \n",
       "6                           0.0                        0.0          1.0   \n",
       "2                           0.0                        0.0          0.0   \n",
       "9                           0.0                        0.0          0.0   \n",
       "10                          0.0                        0.0          0.0   \n",
       "0                           0.0                        0.0          0.0   \n",
       "11                          0.0                        0.0          1.0   \n",
       "3                           0.0                        0.0          0.0   \n",
       "7                           0.0                        0.0          0.0   \n",
       "4                           0.0                        0.0          0.0   \n",
       "\n",
       "    Drosophila melanogaster  Lactobacillus casei  Candida albicans SC5314  \\\n",
       "12                      1.0                  0.0                      1.0   \n",
       "13                      0.0                  1.0                      0.0   \n",
       "1                       0.0                  0.0                      0.0   \n",
       "5                       0.0                  0.0                      0.0   \n",
       "8                       0.0                  1.0                      0.0   \n",
       "6                       1.0                  0.0                      0.0   \n",
       "2                       0.0                  0.0                      0.0   \n",
       "9                       0.0                  0.0                      1.0   \n",
       "10                      0.0                  0.0                      0.0   \n",
       "0                       0.0                  0.0                      0.0   \n",
       "11                      1.0                  0.0                      0.0   \n",
       "3                       0.0                  0.0                      0.0   \n",
       "7                       0.0                  0.0                      0.0   \n",
       "4                       0.0                  0.0                      0.0   \n",
       "\n",
       "    Dictyostelium discoideum  Pseudomonas aeruginosa  \n",
       "12                       1.0                     0.0  \n",
       "13                       0.0                     1.0  \n",
       "1                        0.0                     0.0  \n",
       "5                        0.0                     0.0  \n",
       "8                        0.0                     0.0  \n",
       "6                        0.0                     0.0  \n",
       "2                        0.0                     0.0  \n",
       "9                        0.0                     0.0  \n",
       "10                       1.0                     0.0  \n",
       "0                        0.0                     0.0  \n",
       "11                       0.0                     0.0  \n",
       "3                        0.0                     0.0  \n",
       "7                        0.0                     0.0  \n",
       "4                        0.0                     0.0  "
      ]
     },
     "execution_count": 69,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "summarize_set(descendants, facet_fields=['taxon_subset_closure_label'])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
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