Response to "Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power"
See our manuscript On powerful GWAS in admixed populations, Nat. Genet. 2021.
This repository is mainly for reproducing results of the manuscript. Go to admix-kit software package if you want to perform similar analysis.
See simulation study for
- main figure.
- qq plot and false positive ratio in the null simulation.
- extended results of power.
- association testing when the causal SNP is not typed
See real data study for analyses of known risk reigons (LDLR, APOE, PCSK9, SORT1) for lipids traits (LDL, TC) in 4,327 individuals with European and African ancestries.
See directory simulation, ukb for details of simulation and real data analysis.