bulkDGD is a Python package providing an interface to use the Deep Generative Decoder (DGD) developed by Schuster and Krogh (Schuster and Krogh, 2023) to model the gene expression of healthy human tissues from bulk RNA-Seq data.

The first application of the model to bulk RNA-Seq data is presented in the work of Prada-Luengo, Schuster, Liang, and coworkers (Prada-Luego, Schuster, Liang, et al., 2023).

• Documentation: bulkDGD's documentation can be found here.
• Bug reports: please report any bugs or problems you encounter with bulkDGD in the dedicated issues section on GitHub.

License

bulkDGD is freely available under the terms of the GNU General Public License (Version 3, 29 June 2007).

References

(Schuster and Krogh, 2023) Schuster, Viktoria, and Anders Krogh. "The Deep Generative Decoder: MAP estimation of representations improves modelling of single-cell RNA data." Bioinformatics 39.9 (2023): btad497.

(Prada-Luengo, Schuster, Liang, et al., 2023) Prada-Luengo, Iñigo, et al. "N-of-one differential gene expression without control samples using a deep generative model." Genome Biology 24.1 (2023): 263.