tutorials/mpbn/Bladder_Remy2015.ipynb

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    "# Application of MPBNs to the Bladder Tumorigenesis model by Remy et al. 2015\n",
    "\n",
    "We use Most Permissive Boolean Networks to analyze *reachable* attractors in the logical model published in [(Remy et al., 2015)](https://doi.org/10.1158/0008-5472.CAN-15-0602), by reproducing part of the experiments performed in [Estimating Attractor Reachability in Asynchronous Logical Models (Mendes et al, 2018](https://doi.org/10.3389/fphys.2018.01161) (Table 3).\n",
    "\n",
    "Note that, currently, the `mpbn` tool does not provide quantification of the propensity of reachable attractors. However, it guarantees their exhaustive identification."
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   "source": [
    "import biolqm\n",
    "import ginsim\n",
    "import mpbn\n",
    "from colomoto_jupyter import tabulate"
   ]
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   "source": [
    "## Model\n",
    "\n",
    "### Original multivalued model"
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       "Downloading http://ginsim.org/sites/default/files/Bladder_Model.zginml"
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      ],
      "text/plain": [
       "<IPython.core.display.HTML object>"
      ]
     },
     "execution_count": 2,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "lrg = ginsim.load(\"http://ginsim.org/sites/default/files/Bladder_Model.zginml\")\n",
    "ginsim.show(lrg)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "We use `biolqm` to convert it to a pure Boolean model."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "35"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "bn = biolqm.to_minibn(biolqm.booleanize(lrg.getModel()))\n",
    "mbn = mpbn.MPBooleanNetwork(bn)\n",
    "len(mbn) # display number of components"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['DNAdamage', 'EGFR_stimulus', 'FGFR3_stimulus', 'GrowthInhibitors']"
      ]
     },
     "execution_count": 4,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "inputs = bn.inputs()\n",
    "inputs"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [],
   "source": [
    "outputs = [\"Apoptosis_b1\", \"Growth_Arrest\", \"Proliferation\"]\n",
    "non_outputs = [n for n in bn if n not in outputs]"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Attractors\n",
    "\n",
    "We first compute the full list of attractors of the Most Permissive semantics.\n",
    "We recover exactly the same number as reported in the original publication."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 6.12 ms, sys: 1.01 ms, total: 7.14 ms\n",
      "Wall time: 6.82 ms\n"
     ]
    },
    {
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       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>1</td>\n",
       "      <td>*</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>1</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>*</td>\n",
       "      <td>0</td>\n",
       "      <td>0</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   AKT  ATM_b1  ATM_b2  Apoptosis_b1  Apoptosis_b2 CDC25A  CHEK1_2_b1  \\\n",
       "0    0       0       0             0             0      0           0   \n",
       "1    0       0       0             0             0      0           0   \n",
       "2    0       0       0             0             0      0           0   \n",
       "3    0       0       0             0             0      0           0   \n",
       "4    0       0       0             0             0      0           0   \n",
       "5    0       0       0             0             0      0           0   \n",
       "6    0       0       0             0             0      0           0   \n",
       "7    0       0       0             0             0      1           0   \n",
       "8    0       0       0             0             0      1           0   \n",
       "9    0       0       0             0             0      1           0   \n",
       "10   0       0       0             0             0      1           0   \n",
       "11   0       1       0             1             0      0           1   \n",
       "12   0       1       0             1             0      0           1   \n",
       "13   0       1       0             1             0      0           1   \n",
       "14   0       1       0             1             0      0           1   \n",
       "15   0       1       0             1             0      0           1   \n",
       "16   0       1       0             1             0      0           1   \n",
       "17   0       1       0             1             0      0           1   \n",
       "18   0       1       0             1             0      0           1   \n",
       "19   0       1       0             1             0      0           1   \n",
       "20   0       1       0             1             0      0           1   \n",
       "21   0       1       0             1             0      0           1   \n",
       "22   0       1       0             1             0      0           1   \n",
       "23   *       0       0             0             0      0           0   \n",
       "24   *       0       0             0             0      *           0   \n",
       "\n",
       "    CHEK1_2_b2 CyclinA CyclinD1 CyclinE1  DNAdamage E2F1_b1  E2F1_b2 E2F3_b1  \\\n",
       "0            0       0        0        0          0       0        0       0   \n",
       "1            0       0        0        0          0       0        0       0   \n",
       "2            0       0        0        0          0       0        0       0   \n",
       "3            0       0        0        0          0       0        0       0   \n",
       "4            0       0        0        0          0       0        0       0   \n",
       "5            0       0        0        0          0       0        0       1   \n",
       "6            0       0        0        0          0       0        0       1   \n",
       "7            0       1        0        1          0       1        0       1   \n",
       "8            0       1        0        1          0       1        0       1   \n",
       "9            0       1        1        1          0       1        0       1   \n",
       "10           0       1        1        1          0       1        0       1   \n",
       "11           0       0        0        0          1       0        0       0   \n",
       "12           0       0        0        0          1       0        0       0   \n",
       "13           0       0        0        0          1       0        0       0   \n",
       "14           0       0        0        0          1       0        0       0   \n",
       "15           0       0        0        0          1       0        0       0   \n",
       "16           0       0        0        0          1       0        0       0   \n",
       "17           0       0        0        0          1       0        0       0   \n",
       "18           0       0        0        0          1       0        0       0   \n",
       "19           0       0        0        0          1       0        0       0   \n",
       "20           0       0        0        0          1       0        0       1   \n",
       "21           0       0        0        0          1       0        0       1   \n",
       "22           0       0        0        0          1       0        0       *   \n",
       "23           0       0        0        0          0       0        0       *   \n",
       "24           0       *        *        *          0       *        0       *   \n",
       "\n",
       "    E2F3_b2 EGFR  EGFR_stimulus  FGFR3  FGFR3_stimulus GRB2  GrowthInhibitors  \\\n",
       "0         0    0              0      0               0    0                 0   \n",
       "1         0    0              0      0               0    0                 1   \n",
       "2         0    0              0      0               0    0                 1   \n",
       "3         0    0              0      1               1    0                 1   \n",
       "4         0    0              1      1               1    0                 1   \n",
       "5         0    0              0      1               1    0                 1   \n",
       "6         0    0              1      1               1    0                 1   \n",
       "7         0    0              0      1               1    0                 1   \n",
       "8         0    0              1      1               1    0                 1   \n",
       "9         0    0              0      1               1    0                 0   \n",
       "10        0    0              1      1               1    0                 0   \n",
       "11        0    0              0      0               0    0                 0   \n",
       "12        0    0              0      0               0    0                 1   \n",
       "13        0    0              0      0               0    0                 1   \n",
       "14        0    0              0      1               1    0                 0   \n",
       "15        0    0              0      1               1    0                 1   \n",
       "16        0    0              1      1               1    0                 0   \n",
       "17        0    0              1      1               1    0                 1   \n",
       "18        0    *              1      0               0    *                 0   \n",
       "19        0    *              1      0               0    *                 1   \n",
       "20        0    0              0      1               1    0                 1   \n",
       "21        0    0              1      1               1    0                 1   \n",
       "22        0    *              1      0               0    *                 1   \n",
       "23        0    *              1      0               0    *                 1   \n",
       "24        0    *              1      0               0    *                 0   \n",
       "\n",
       "   Growth_Arrest MDM2 PI3K  PTEN Proliferation RAS RB1 RBL2 SPRY  TP53 p14ARF  \\\n",
       "0              1    0    0     0             0   0   1    1    0     0      0   \n",
       "1              1    0    0     0             0   0   0    1    0     0      0   \n",
       "2              1    0    0     0             0   0   1    1    0     0      0   \n",
       "3              1    0    0     0             0   1   1    1    1     0      0   \n",
       "4              1    0    0     0             0   1   1    1    1     0      0   \n",
       "5              1    0    0     0             0   1   0    1    1     0      0   \n",
       "6              1    0    0     0             0   1   0    1    1     0      0   \n",
       "7              0    0    0     0             1   1   0    0    1     0      1   \n",
       "8              0    0    0     0             1   1   0    0    1     0      1   \n",
       "9              0    0    0     0             1   1   0    0    1     0      1   \n",
       "10             0    0    0     0             1   1   0    0    1     0      1   \n",
       "11             1    0    0     1             0   0   1    1    0     1      0   \n",
       "12             1    0    0     1             0   0   0    1    0     1      0   \n",
       "13             1    0    0     1             0   0   1    1    0     1      0   \n",
       "14             1    0    0     1             0   1   1    1    1     1      0   \n",
       "15             1    0    0     1             0   1   1    1    1     1      0   \n",
       "16             1    0    0     1             0   1   1    1    1     1      0   \n",
       "17             1    0    0     1             0   1   1    1    1     1      0   \n",
       "18             1    0    0     1             0   *   1    1    *     1      0   \n",
       "19             1    0    0     1             0   *   1    1    *     1      0   \n",
       "20             1    0    0     1             0   1   0    1    1     1      0   \n",
       "21             1    0    0     1             0   1   0    1    1     1      0   \n",
       "22             1    0    0     1             0   *   0    1    *     1      0   \n",
       "23             1    *    *     0             0   *   0    1    *     0      0   \n",
       "24             *    *    *     0             *   *   *    *    *     0      *   \n",
       "\n",
       "    p16INK4a p21CIP  \n",
       "0          0      0  \n",
       "1          1      1  \n",
       "2          0      1  \n",
       "3          0      1  \n",
       "4          0      1  \n",
       "5          1      1  \n",
       "6          1      1  \n",
       "7          1      0  \n",
       "8          1      0  \n",
       "9          0      0  \n",
       "10         0      0  \n",
       "11         0      1  \n",
       "12         1      1  \n",
       "13         0      1  \n",
       "14         0      1  \n",
       "15         0      1  \n",
       "16         0      1  \n",
       "17         0      1  \n",
       "18         0      1  \n",
       "19         0      1  \n",
       "20         1      1  \n",
       "21         1      1  \n",
       "22         1      1  \n",
       "23         1      *  \n",
       "24         0      0  "
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "%time a = list(mbn.attractors())\n",
    "tabulate(a)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "To have a better overview of the input/output behaviour, we display the attractors by selecting only input and output components and then only output components."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "      <th></th>\n",
       "      <th>DNAdamage</th>\n",
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       "      <td>1</td>\n",
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      ],
      "text/plain": [
       "    DNAdamage  EGFR_stimulus  FGFR3_stimulus  GrowthInhibitors  Apoptosis_b1  \\\n",
       "0           0              0               0                 0             0   \n",
       "1           0              0               0                 1             0   \n",
       "2           0              0               1                 0             0   \n",
       "3           0              0               1                 1             0   \n",
       "4           0              0               1                 1             0   \n",
       "5           0              1               0                 0             0   \n",
       "6           0              1               0                 1             0   \n",
       "7           0              1               1                 0             0   \n",
       "8           0              1               1                 1             0   \n",
       "9           0              1               1                 1             0   \n",
       "10          1              0               0                 0             1   \n",
       "11          1              0               0                 1             1   \n",
       "12          1              0               1                 0             1   \n",
       "13          1              0               1                 1             1   \n",
       "14          1              1               0                 0             1   \n",
       "15          1              1               0                 1             1   \n",
       "16          1              1               1                 0             1   \n",
       "17          1              1               1                 1             1   \n",
       "\n",
       "   Growth_Arrest Proliferation  \n",
       "0              1             0  \n",
       "1              1             0  \n",
       "2              0             1  \n",
       "3              0             1  \n",
       "4              1             0  \n",
       "5              *             *  \n",
       "6              1             0  \n",
       "7              0             1  \n",
       "8              0             1  \n",
       "9              1             0  \n",
       "10             1             0  \n",
       "11             1             0  \n",
       "12             1             0  \n",
       "13             1             0  \n",
       "14             1             0  \n",
       "15             1             0  \n",
       "16             1             0  \n",
       "17             1             0  "
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "tabulate(a, columns=inputs+outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "      <th>Growth_Arrest</th>\n",
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      "text/plain": [
       "   Apoptosis_b1 Growth_Arrest Proliferation\n",
       "0             0             0             1\n",
       "1             0             1             0\n",
       "2             0             *             *\n",
       "3             1             1             0"
      ]
     },
     "execution_count": 8,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "tabulate(a, columns=outputs)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Reachable attractors\n",
    "\n",
    "For different input settings, and starting from all the other nodes being inactive, we compute the reachable attractors in the wild-type model."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [],
   "source": [
    "all_zero = dict([(n,0) for n in bn])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 8.46 ms, sys: 27 µs, total: 8.48 ms\n",
      "Wall time: 7.92 ms\n"
     ]
    },
    {
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       "      <th>Apoptosis_b1</th>\n",
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       "      <th>Proliferation</th>\n",
       "      <th>AKT</th>\n",
       "      <th>ATM_b1</th>\n",
       "      <th>ATM_b2</th>\n",
       "      <th>Apoptosis_b2</th>\n",
       "      <th>CDC25A</th>\n",
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       "   Apoptosis_b1  Growth_Arrest  Proliferation  AKT  ATM_b1  ATM_b2  \\\n",
       "0             0              1              0    0       0       0   \n",
       "1             0              1              0    0       0       0   \n",
       "\n",
       "   Apoptosis_b2  CDC25A  CHEK1_2_b1  CHEK1_2_b2  CyclinA  CyclinD1  CyclinE1  \\\n",
       "0             0       0           0           0        0         0         0   \n",
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       "\n",
       "   DNAdamage  E2F1_b1  E2F1_b2  E2F3_b1  E2F3_b2  EGFR  EGFR_stimulus  FGFR3  \\\n",
       "0          0        0        0        0        0     0              0      0   \n",
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       "\n",
       "   FGFR3_stimulus  GRB2  GrowthInhibitors  MDM2  PI3K  PTEN  RAS  RB1  RBL2  \\\n",
       "0               0     0                 1     0     0     0    0    0     1   \n",
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       "\n",
       "   SPRY  TP53  p14ARF  p16INK4a  p21CIP  \n",
       "0     0     0       0         1       1  \n",
       "1     0     0       0         0       1  "
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "init = all_zero.copy()\n",
    "init[\"GrowthInhibitors\"] = 1\n",
    "%time a = list(mbn.attractors(reachable_from=init))\n",
    "tabulate(a, columns=outputs+non_outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 10.2 ms, sys: 60 µs, total: 10.2 ms\n",
      "Wall time: 9.19 ms\n"
     ]
    },
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       "   Apoptosis_b1 Growth_Arrest Proliferation AKT  ATM_b1  ATM_b2  Apoptosis_b2  \\\n",
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     "metadata": {},
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   "source": [
    "init = all_zero.copy()\n",
    "init[\"EGFR_stimulus\"] = 1\n",
    "%time a = list(mbn.attractors(reachable_from=init))\n",
    "tabulate(a, columns=outputs+non_outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 12,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 10.3 ms, sys: 7 µs, total: 10.3 ms\n",
      "Wall time: 9.25 ms\n"
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    },
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   "source": [
    "init = all_zero.copy()\n",
    "init[\"EGFR_stimulus\"] = 1\n",
    "init[\"GrowthInhibitors\"] = 1\n",
    "%time a = list(mbn.attractors(reachable_from=init))\n",
    "tabulate(a, columns=outputs+non_outputs)"
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  {
   "cell_type": "code",
   "execution_count": 13,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 11 ms, sys: 0 ns, total: 11 ms\n",
      "Wall time: 9.83 ms\n"
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       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ],
      "text/plain": [
       "   Apoptosis_b1  Growth_Arrest  Proliferation  AKT  ATM_b1  ATM_b2  \\\n",
       "0             0              0              1    0       0       0   \n",
       "1             0              1              0    0       0       0   \n",
       "2             0              1              0    0       0       0   \n",
       "\n",
       "   Apoptosis_b2  CDC25A  CHEK1_2_b1  CHEK1_2_b2  CyclinA  CyclinD1  CyclinE1  \\\n",
       "0             0       1           0           0        1         0         1   \n",
       "1             0       0           0           0        0         0         0   \n",
       "2             0       0           0           0        0         0         0   \n",
       "\n",
       "   DNAdamage  E2F1_b1  E2F1_b2  E2F3_b1  E2F3_b2  EGFR  EGFR_stimulus  FGFR3  \\\n",
       "0          0        1        0        1        0     0              1      1   \n",
       "1          0        0        0        0        0     0              1      1   \n",
       "2          0        0        0        1        0     0              1      1   \n",
       "\n",
       "   FGFR3_stimulus  GRB2  GrowthInhibitors  MDM2  PI3K  PTEN  RAS  RB1  RBL2  \\\n",
       "0               1     0                 1     0     0     0    1    0     0   \n",
       "1               1     0                 1     0     0     0    1    1     1   \n",
       "2               1     0                 1     0     0     0    1    0     1   \n",
       "\n",
       "   SPRY  TP53  p14ARF  p16INK4a  p21CIP  \n",
       "0     1     0       1         1       0  \n",
       "1     1     0       0         0       1  \n",
       "2     1     0       0         1       1  "
      ]
     },
     "execution_count": 13,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "init = all_zero.copy()\n",
    "init[\"EGFR_stimulus\"] = 1\n",
    "init[\"FGFR3_stimulus\"] = 1\n",
    "init[\"GrowthInhibitors\"] = 1\n",
    "%time a = list(mbn.attractors(reachable_from=init))\n",
    "tabulate(a, columns=outputs+non_outputs)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Attractors with model perturbations\n",
    "\n",
    "We reproduce the analysis of attractors under various mutations, focusing when `DNAdamage` is off. They match with Table 2 of [(Remy et al., 2015)](https://doi.org/10.3389/fbioe.2014.00086)."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 7.73 ms, sys: 1.04 ms, total: 8.77 ms\n",
      "Wall time: 7.45 ms\n"
     ]
    },
    {
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       "   Apoptosis_b1 Growth_Arrest Proliferation\n",
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     "execution_count": 14,
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   "source": [
    "%time a = list(mbn.attractors(constraints={\"DNAdamage\":0}))\n",
    "tabulate(a, columns=outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 15,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 6.33 ms, sys: 905 µs, total: 7.24 ms\n",
      "Wall time: 6.42 ms\n"
     ]
    },
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   "source": [
    "bn_mut = mbn.copy()\n",
    "bn_mut[\"FGFR3\"] = 1\n",
    "%time a = list(bn_mut.attractors(constraints={\"DNAdamage\":0}))\n",
    "tabulate(a, columns=outputs)"
   ]
  },
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   "cell_type": "code",
   "execution_count": 16,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 7.59 ms, sys: 6 µs, total: 7.6 ms\n",
      "Wall time: 6.67 ms\n"
     ]
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       "   Apoptosis_b1  Growth_Arrest Proliferation\n",
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       "2             0              0             *\n",
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     "metadata": {},
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   "source": [
    "bn_mut = mbn.copy()\n",
    "bn_mut[\"PI3K\"] = 1\n",
    "%time a = list(bn_mut.attractors(constraints={\"DNAdamage\":0}))\n",
    "tabulate(a, columns=outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 17,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 8.13 ms, sys: 6 µs, total: 8.14 ms\n",
      "Wall time: 7.05 ms\n"
     ]
    },
    {
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   "source": [
    "bn_mut = mbn.copy()\n",
    "bn_mut[\"PI3K\"] = 1\n",
    "bn_mut[\"FGFR3\"] = 1\n",
    "%time a = list(bn_mut.attractors(constraints={\"DNAdamage\":0}))\n",
    "tabulate(a, columns=outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "metadata": {},
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    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CPU times: user 6.14 ms, sys: 65 µs, total: 6.2 ms\n",
      "Wall time: 5.33 ms\n"
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       "   Apoptosis_b1  Growth_Arrest  Proliferation\n",
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   ],
   "source": [
    "bn_mut = mbn.copy()\n",
    "bn_mut[\"PI3K\"] = 1\n",
    "bn_mut[\"FGFR3\"] = 1\n",
    "bn_mut[\"p16INK4a\"] = 0\n",
    "%time a = list(bn_mut.attractors(constraints={\"DNAdamage\":0}))\n",
    "tabulate(a, columns=outputs)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
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