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DESCRIPTION
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DESCRIPTION
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Package: POINT
Type: Package
Title: Protein Structure Guided Local Test
Version: 1.3
Date: 2023-10-01
Author: Rachel Marceau West, Shannon T. Holloway
Maintainer: Shannon T. Holloway <shannon.t.holloway@gmail.com>
Description: Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.
License: GPL-2
Depends: methods, stats, rARPACK, Matrix, CompQuadForm
NeedsCompilation: no
Encoding: UTF-8
RoxygenNote: 7.2.1
Collate: 'A_Kernel.R' 'A_BurdenKernel.R' 'A_LinearKernel.R'
'A_PolyKernel.R' 'B_PvMethod.R' 'B_PvMethod_Davies.R'
'B_PvMethod_Liu.R' 'C_BinomialTrait.R' 'C_GaussianTrait.R'
'D_NullResult.R' 'calcLocalKernel.R' 'distanceMatrix.R'
'mainCode.R' 'point.R' 'pvResamp.R'
Packaged: 2023-10-01 17:33:27 UTC; 19194
Repository: CRAN
Date/Publication: 2023-10-01 18:00:02 UTC