This software code provides a model of the rabbit cardiac action potential described in [1]. The model code is written in CellML which is an open standard based on the XML markup language [2]. The model was derived from high-fidelity experimental data from the rabbit (both single cells and during propagation in the isolated whole heart). This model of the ‘parsimonious’ rabbit action potential is very simple with only two currents and three variables, including a novel non-linear phenomenological model of repolarization. The novelty of this model is that it is mathematically identifiable and extremely simple. The model allows a prediction of the dynamical patterns during ventricular fibrillation in the rabbit. For more information about the model please refer to [1]. There are a variety of OpenSource Tools to run this CellML model (see [2]).
The code itself is provided in the two files (representing two types of stimulation: current clamp or voltage clamp):
PR-2016-with-stimulus.cellml for current clamp & PR-2016-with-holding.cellml for voltage clamp
Disclaimer: This software and documentation (the "Software") were developed at the Food and Drug Administration (FDA) by employees of the Federal Government in the course of their official duties. Pursuant to Title 17, Section 105 of the United States Code, this work is not subject to copyright protection and is in the public domain. Permission is hereby granted, free of charge, to any person obtaining a copy of the Software, to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, or sell copies of the Software or derivatives, and to permit persons to whom the Software is furnished to do so. FDA assumes no responsibility whatsoever for use by other parties of the Software, its source code, documentation or compiled executables, and makes no guarantees, expressed or implied, about its quality, reliability, or any other characteristic. Further, use of this code in no way implies endorsement by the FDA or confers any advantage in regulatory decisions. Although this software can be redistributed and/or modified freely, we ask that any derivative works bear some notice that they are derived from it, and any modified versions bear some notice that they have been modified.
References
[1] Gray RA, Pathmanathan P. A Parsimonious Model of the Rabbit Action Potential Elucidates the Minimal Physiological Requirements for Alternans and Spiral Wave Breakup. PLOS Computational Biology, 2016, 12(10): e1005087. doi:10.1371/journal.pcbi.1005087. https://pubmed.ncbi.nlm.nih.gov/27749895/
[2] CellML.Org