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pr-2016-with-holding.cellml
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pr-2016-with-holding.cellml
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<?xml version="1.0" encoding="utf-8"?>
<model name="generated_model" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#">
<units name="ms">
<unit exponent="1" multiplier="0.001" units="second"/>
</units>
<units name="A_per_F">
<unit exponent="1" multiplier="1000.0" units="gram"/>
<unit exponent="2" units="metre"/>
<unit exponent="-4" units="second"/>
<unit exponent="-1" units="ampere"/>
</units>
<units name="per_mV">
<unit exponent="-1" units="gram"/>
<unit exponent="-2" units="metre"/>
<unit exponent="3" units="second"/>
<unit exponent="1" units="ampere"/>
</units>
<units name="mS_per_uF">
<unit exponent="-1" multiplier="1000.0" units="second"/>
</units>
<units name="mV">
<unit exponent="1" units="gram"/>
<unit exponent="2" units="metre"/>
<unit exponent="-3" units="second"/>
<unit exponent="-1" units="ampere"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML"/>
</component>
<component name="ik">
<variable name="IK" public_interface="out" units="A_per_F"/>
<variable initial_value="0.047" name="b" units="per_mV"/>
<variable initial_value="0.3" name="ik_g" units="mS_per_uF"/>
<variable initial_value="-83.0" name="EK" units="mV"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IK</ci>
<apply>
<times/>
<apply>
<times/>
<ci>ik_g</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>b</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>EK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ina">
<variable initial_value="65.0" name="ENa" units="mV"/>
<variable initial_value="0.0" name="m" units="dimensionless"/>
<variable name="INa" public_interface="out" units="A_per_F"/>
<variable initial_value="11.0" name="ina_g" units="mS_per_uF"/>
<variable initial_value="0.86" name="h" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="ina_h_tau" public_interface="in" units="ms"/>
<variable name="ina_h_inf" public_interface="in" units="dimensionless"/>
<variable name="ina_m_tau" public_interface="in" units="ms"/>
<variable name="ina_m_inf" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ina_m_inf</ci>
<ci>m</ci>
</apply>
<ci>ina_m_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>INa</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<ci>ina_g</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
<ci>h</ci>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ina_h_inf</ci>
<ci>h</ci>
</apply>
<ci>ina_h_tau</ci>
</apply>
</apply>
</math>
</component>
<component name="ina_m">
<variable initial_value="0.12" name="ina_m_tau" public_interface="out" units="ms"/>
<variable name="ina_m_inf" public_interface="out" units="dimensionless"/>
<variable initial_value="-41.0" name="ina_m_E" units="mV"/>
<variable initial_value="-4.0" name="ina_m_k" units="mV"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ina_m_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<ci>ina_m_E</ci>
</apply>
<ci>ina_m_k</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ina_h">
<variable name="ina_h_tau" public_interface="out" units="ms"/>
<variable initial_value="-74.7" name="ina_h_E" units="mV"/>
<variable initial_value="0.799163" name="d" units="dimensionless"/>
<variable initial_value="4.4" name="ina_h_k" units="mV"/>
<variable initial_value="6.80738" name="t0" units="ms"/>
<variable name="ina_h_inf" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ina_h_tau</ci>
<apply>
<times/>
<apply>
<times/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.0</cn>
<ci>t0</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>d</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ina_h_E</ci>
</apply>
</apply>
<ci>ina_h_k</ci>
</apply>
</apply>
</apply>
<ci>ina_h_inf</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ina_h_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<ci>ina_h_E</ci>
</apply>
<ci>ina_h_k</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable initial_value="1.0" name="C" units="dimensionless"/>
<variable name="i_ion" units="A_per_F"/>
<variable name="stim_time" units="ms"/>
<variable initial_value="-83.0" name="V" public_interface="out" units="mV"/>
<variable name="dvdt_free" units="A_per_F"/>
<variable initial_value="2.0" name="stim_duration" units="ms"/>
<variable name="dvdt_clamp" units="A_per_F"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="INa" public_interface="in" units="A_per_F"/>
<variable name="IK" public_interface="in" units="A_per_F"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ion</ci>
<apply>
<plus/>
<ci>INa</ci>
<ci>IK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>stim_time</ci>
<apply>
<rem/>
<apply>
<plus/>
<ci>time</ci>
<cn cellml:units="ms">400.0</cn>
</apply>
<cn cellml:units="ms">500.0</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<piecewise>
<piece>
<ci>dvdt_clamp</ci>
<apply>
<lt/>
<ci>stim_time</ci>
<ci>stim_duration</ci>
</apply>
</piece>
<otherwise>
<ci>dvdt_free</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>dvdt_free</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>C</ci>
</apply>
<ci>i_ion</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dvdt_clamp</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="mV">10.0</cn>
<ci>V</ci>
</apply>
<cn cellml:units="ms">0.001</cn>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="membrane"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="ina"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ina" component_2="ina_h"/>
<map_variables variable_1="ina_h_tau" variable_2="ina_h_tau"/>
<map_variables variable_1="ina_h_inf" variable_2="ina_h_inf"/>
</connection>
<connection>
<map_components component_1="ina_h" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ik" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="IK" variable_2="IK"/>
</connection>
<connection>
<map_components component_1="ina" component_2="membrane"/>
<map_variables variable_1="INa" variable_2="INa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="ina" component_2="ina_m"/>
<map_variables variable_1="ina_m_tau" variable_2="ina_m_tau"/>
<map_variables variable_1="ina_m_inf" variable_2="ina_m_inf"/>
</connection>
<connection>
<map_components component_1="ina_m" component_2="membrane"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
</model>