auto brewery syndrome

[lschriml]

add to DO:
https://www.ncbi.nlm.nih.gov/books/NBK513346/

[lschriml]

Notes:
a child of : acquired metabolic disease
-- Ethanol fermentation
-- Ethanol production by fermenting yeast and bacteria
-- Alcoholic fermentation is a metabolic process located downstream of glycolysis.
-- Both BFS and GFS are triggered by deranged microbiota within the hollow organs, leading to ethanol fermentation due to the overgrowth of fermenting yeast within the bladder and gut.

auto brewery syndrome
auto-brewery syndrome
synonym: gut fermentation syndrome

defn:
-- characterized by the endogenous production of alcohol
-- ethanol is produced through endogenous fermentation by fungi or bacteria in the gastrointestinal (GI) system, oral cavity, or urinary system.
-- It typically presents with the signs of alcohol intoxication

-- Various yeasts from the Candida and Saccharomyces families are commensals turned pathogenic that cause auto-brewery syndrome

-- patients with gut fermentation syndrome (GFS) or auto-brewery syndrome can spontaneously develop symptoms of ethanol intoxication even without any alcohol ingestion because of alcoholic fermentation in the gut lumen.

URLs:
https://www.ncbi.nlm.nih.gov/books/NBK513346/
https://en.wikipedia.org/wiki/Auto-brewery_syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667719/
https://pubmed.ncbi.nlm.nih.gov/38246992/

2nd disease:
bladder fermentation syndrome (BFS) or urinary auto-brewery syndrome

--> In BFS, ethanol is generated by Crabtree-positive fermenting yeast Candida glabrata in a patient with poorly controlled diabetes
-- One crucial characteristic of BFS is the absence of alcoholic intoxication, as the bladder lumen contains transitional epithelium with low ethanol permeability

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03241-7
https://pubmed.ncbi.nlm.nih.gov/38246992/

[lschriml]

added to DO. .