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{{/*
BOOSTER-WEB: Web interface to BOOSTER (https://github.com/evolbioinfo/booster)
Alternative method to compute bootstrap branch supports in large trees.
Copyright (C) 2017 BOOSTER-WEB dev team
This program is free software; you can redistribute it and/or
modify it under the terms of the GNU General Public License
as published by the Free Software Foundation; either version 2
of the License, or (at your option) any later version.
This program is distributed in the hope that it will be useful,
but WITHOUT ANY WARRANTY; without even the implied warranty of
MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the
GNU General Public License for more details.
You should have received a copy of the GNU General Public License
along with this program; if not, write to the Free Software
Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA.
*/}}
{{ define "title" }}
BOOSTER - BOOtstrap Support by TransfER
{{ end }}
{{ define "libs" }}
{{ end }}
{{ define "content" }}
<div>
<div style="float:right;">
<img src="/static/img/hiv.png" style="width:500px;"/>
</div>
<p>BOOSTER is an alternative method for calculating the branch supports of phylogenetic trees, using the bootstrap. With large trees and moderate phylogenetic signal, BOOSTER tends to be more informative than the standard Felsenstein bootstrap method.</p>
<p>BOOSTER's approach has a simple but sound statistical foundation. It replaces the branch presence proportion (i.e. the expectation of a {0,1} indicator function) of Felsenstein's bootstrap, by the expectation of a refined, gradual function in the [0,1] range, quantifying branch presence in the bootstrap trees.</p>
<p>BOOSTER is especially relevant with deep branches and large datasets, where branches known to be (nearly) correct are supported by the transfer bootstrap while they are not by Felsenstein's method. Though higher, BOOSTER supports are not impeded with falsely supported branches.</p>
<p>You need two files to run BOOSTER: one with the reference tree inferred using your preferred method; the second with the bootstrap trees inferred using the same method from the bootstrapped alignments. With multiple alignments of moderate size (< 3,000 taxa, < 10,000 sites), our webserver can also run PhyML and FastTree to infer the reference and bootstrap trees, and then run BOOSTER.</p>
<p>BOOSTER C code is open source and available on <a href="https://github.com/evolbioinfo/booster/">GitHub</a>.</p>
<p>The transfer bootstrap is available in several phylogenetic programs: PhyML, SeaView, RaXML-NG, and others.</p>
<p><u>Please send your comments and/or suggestions to</u>: frederic[dot]lemoine[at]pasteur[dot]fr and olivier[dot]gascuel[at]pasteur[dot]fr, Unité Bioinformatique Évolutive, C3BI USR 3756, Institut Pasteur and CNRS, Paris, France </p>
<h2>News</h2>
<ul>
<li>2018/10: <a href="https://github.com/amkozlov/raxml-ng/releases">RAxML-NG</a> (≤v0.7.0 BETA) implements Transfer Bootstrap (option --bs-metric tbe).</li>
<li>2018/09: <a href="https://github.com/Cibiv/IQ-TREE/releases">IQ-TREE</a> (≤ v1.7-beta) implements Transfer Bootstrap (option --tbe).</li>
<li>2017/11: PhyML and FastTree are integrated in Booster web service.
<li>2017/10: PhyML now implements Transfer Bootstrap (option --tbe, see <a href="https://github.com/stephaneguindon/phyml">GitHub repository</a>). </li>
</ul>
<h2>More information</h2>
<ul>
<li>To learn more about BOOSTER, please read our <a href="/help">help page</a>;</li>
<li>The preprint with all details and results is available on <a href="https://doi.org/10.1101/154542">bioRxiv</a>.</li>
</ul>
<h2>References</h2>
<ul>
<li>Renewing Felsenstein's Phylogenetic Bootstrap in the Era of Big Data, <a href="https://doi.org/10.1038/s41586-018-0043-0">Nature <span style="font-weight:bold;">556</span>, 452-456 (2018)</a>
<p>F. Lemoine, J.-B. Domelevo-Entfellner, E. Wilkinson, D. Correia, M. Davila Felipe, T. De Oliveira, O. Gascuel</p>
<a href="https://f1000.com/prime/733069056?bd=1" target="_blank"><img src="https://s3.amazonaws.com/cdn.f1000.com/images/badges/badgef1000.gif" alt="Access the recommendation on F1000Prime" id="bg" /></a>
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030568/" target="_blank"><img style="height:50px;" src="/static/img/pmc.png" alt="Available on Pubmed Central" id="bg" /></a>
</li>
</ul>
<h2>Data</h2>
<ul>
<li>The archive containing all data described in the paper can be downloaded from the <a href="https://github.com/evolbioinfo/booster-workflows/releases">github page</a></li>
</ul>
</div>
<div style="">
<h2>Run BOOSTER</h2>
<a class="btn btn-primary" href="/new" role="button">Run BOOSTER</a>
</div>
{{ end }}