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<br> <br> <br> <br> <br>
<P class="link"><A href="#" class="minlink" onclick="homeShow();">Home</A></P>
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<DIV id="abstract">
<h2> Feder Research Group in Evolutionary Dynamics </h2>
<hr>
Our goal is to understand the dynamics of rapidly-evolving
populations, especially viruses and bacteria evolving within their hosts and
solid tumors progressing to malignancy. In particular, we are characterizing how spatial organization shapes these evolutionary outcomes, and developing approaches to leverage spatial data to better understand evolutionary histories.
<br><br>
The lab is based in the <a
href="https://www.gs.washington.edu/" class = "minlink">Department
of Genome Sciences</a> at the University of Washington. To learn
more about the goals of the lab, please check out the <a href="#" class="minlink" onclick="researchShow();">research</a> and <a href="#" class="minlink" onclick="publicationsShow();">publication</a> pages.<br> <br>
The lab accepts graduate students through the <a href =
"https://www.gs.washington.edu/academics/gradprogram/index.htm"
class = "minlink">Genome
Sciences</a> and <a href =
"https://mcb-seattle.edu/"
class = "minlink">Molecular and Cellular Biology</a> graduate
programs. Prospective graduate students, rotation students and
postdoctoral fellows are encouraged to <a href="#" class="minlink" onclick="contactShow();">get
in touch</a> with Alison.
<br><br><a href
= "https://www.gs.washington.edu/"> <img src = "https://www.gs.washington.edu/images/newlogo2.png" width = "50%" height = "50%"
style="display:block; margin-left: auto; margin-right: auto;" ></a>
</DIV>
<DIV id="research">
<h2> Research </h2>
<hr>
Evolutionary processes operating inside our bodies are responsible for
a range of adverse disease outcomes, including drug
resistance, immune escape, invasion of new tissue or cell
types, and cancer initiation and progression. A greater
understanding of the forces driving this evolution can inform
therapeutic interventions, and diagnostic and preventative
measures. <br> <br>
While the study of these populations is important for reasons related to human health, these populations also represent important systems for the study of evolution more broadly. Large population sizes, high mutation rates and strong selective pressures mean that these populations have the capacity to evolve rapidly. Because these populations can often also be sampled longitudinally, this gives us a rare opportunity to watch evolution in real time. Furthermore, because we can observe this evolution unfolding in parallel in multiple independent hosts, we have power to understand the generalizability of these processes. Despite the importance of rapid evolutionary processes, population genetics largely historically considered adaptation as a rare event, so quantitative understanding of these data can provide the substrate for new advances in evolutionary theory. <br> <br>
<img src = "img/research/schematic.png" width = "96%" height = "95%">
<br>
A key focus of the lab is in understanding the ways that the <em>intra-host environment</em> shapes evolutionary outcomes of these populations. Humans are not Eppendorf tubes - we’re heterogeneous and spatially structured across multiple levels of biological organization. These environments mediate biotic interactions within and between intra-host populations, shape population demography, and impose heterogeneous challenges for growth. With new opportunities to make spatially-explicit population measurements, we are now poised to develop new insights into how intra-host spatial structure drives disease outcomes. <br> <br>
Some of the interests of the lab include: <br>
<ul>
<li> <b>How do distinct intra-host environments impact the way that populations evolve?</b>
For example, heterogeneous drug concentrations can aid HIV in evolving resistance to antiretrovirals, and evolutionary responses in different spatial anatomical locations can be distinct. Different microenvironmental conditions can permit certain spatial regions of a tumor to evolve faster than others. Differences in lung conditions may drive bacterial resilience in the presence of CF treatments. Understanding how and when these environments contribute is crucial for reconstructing, predicting and steering evolution. <br><br>
<li> <b>How does spatial localization within cells and tissues drive viral evolution and disease progression?</b>
Because viruses need to enter cells in order to replicate, who those viruses enter the cell with can have a major impact on the way that they evolve. For example, this mediates viral opportunities for gene exchange, an important driver of evolutionary diversification. Intriguingly, interactions between co-infecting viruses can sometimes result in the masking of certain phenotypes, which is a property that we might like to exploit to slow drug resistance evolution. Other times, interactions between intracellular viruses can result in new phenotypes entirely, including the ability to spread in novel environments. We are interested in understanding the diverse ways that intracellular viral interaction drives pathogenesis. <br><br>
<li> <b>How important is parallelism in intra-host evolutionary responses?</b>
A longstanding interest of the lab is that in very large populations, populations can have multiple adaptive responses that occur and spread simultaneously (via mutation or plasticity). Parallel adaptation and soft sweeps are a pattern that we see repeatedly across diverse intra-host systems. We are interested in how to detect adaptation in this regime, and understanding the impact that this has on the tempo and mode of evolution.
</ul>
To address these questions, we use a combination of genomic analysis from clinically and experimentally-derived sources, evolutionary and population genetic modeling, and phylogenetics.
<br><br><hr>
Here's a 15 minute video about some of the lab's interests that was
up to date in January 2023: <br><br>
<iframe width="560" height="315" src="https://www.youtube.com/embed/gxSlW2fPtX4" title="Feder lab 15 minute research overview" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe>
<br>
</DIV>
<DIV id="news">
<h2> News </h2>
<hr>
<ul>
<li> <b>Janaury 2024: </b> Elena's paper on HIV recombination is published in <a href =
"https://doi.org/10.1093/molbev/msad260"
class = "minlink">MBE</a>! OUP wrote a nice press release about the
paper that can be found <a href = "https://www.eurekalert.org/news-releases/1030221" class = "minlink">
here</a>. Awesome job, Elena!
<li> <b>December 2023: </b> Will Hannon's genomic analysis of spatial
measles dynamics in the brain (in collaboration with
Iris Yousaf and the Cattaneo lab at Mayo Clinic) is published in <a href =
"https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011817"
class = "minlink">PLOS Pathogens</a> - see some of the nice press coverage <a
href = "https://www.miragenews.com/scientists-uncover-path-of-measles-virus-in-1148868/" class = "minlink"> here</a>.
<li> <b>November 2023: </b> Dylan Clark wins the Katharina Casey Leadership
Award from UW biology - congratulations, Dylan!
<li> <b>September 2023: </b> Dr. Sam Hart jointly joins the Feder and
Harris labs as a postdoctoral scholar. Welcome, Sam! Alex and
Elena are both selected as platform presenters based on the
strength of their posters at
the departmental retreat - awesome job!
<li> <b>August 2023: </b> Alex Robertson wins a spot on the CMB training
grant! Congratulations, Alex! Alison joins the <a href =
"https://www.fredhutch.org/en/research/divisions/public-health-sciences-division/research/computational-biology.html"
class = "minlink">Herbold
Computational Biology Program</a> at the Fred Hutch as an affiliate
investigator. We are looking forward to new opportunities for
interaction within the program.
<li> <b>May 2023: </b> Elena Romero's paper, <a href =
"https://www.biorxiv.org/content/10.1101/2023.05.05.539643v1"
class= "minlink">Elevated HIV viral load is associated with
higher recombination rate <em>in vivo</em></a>, is now available on
BioRxiv.
<li> <b>March 2023: </b> Maya Lewinsohn's paper <a href =
"https://www.nature.com/articles/s41559-023-02000-4"
class= "minlink">State-dependent evolutionary models reveal
modes of solid tumour growth</a> is out in Nature Ecology &
Evolution! See also the accompanying <a href =
"https://www.nature.com/articles/s41559-023-01996-z"
class= "minlink">News & Views article</a>. Congratulations to
Maya and the whole team! Iris Jia joins the lab for a rotation, and
Alex Robertson jointly joins the Feder and Kerr labs! Welcome,
Iris, and welcome back, Alex!
<li> <b>February 2023: </b> Elena Romero is awarded a Young
Investigator Award to attend CROI where she presents her new
findings on HIV recombination. Collaborator Maya Lewinsohn from the Bedford
lab successfully defends her dissertation. Well done, Elena and Maya!
<li> <b>January 2023: </b> Nashwa Ahmed joins the lab for a
rotation. Welcome, Nashwa!
<li> <b>November 2022: </b> A <a
href="https://www.cff.org/researchers/pilot-and-feasibility-awards"
class = "minlink">Pilot and Feasibility Award</a>
from the Cystic Fibrosis Foundation will support our work on
spatial Pseudomonas aeruginosa evolution in CF lungs.
<li> <b>October 2022: </b> An <a
href="https://commonfund.nih.gov/newinnovator/AwardRecipients"
class = "minlink">NIH Director's New Innovator Award</a>
will support our work on cancer evolution. Hunter Colegrove
presents his epithelial modeling work at AISES 2022 and wins
the second place grad oral presentation! Awesome job, Hunter!
<li> <b>September 2022: </b> Dr. Yingnan Gao joins the lab as a
postdoctoral scholar, and Alex Robertson joins for a
rotation. Welcome, Yingnan and Alex!
<li> <b>August 2022: </b> Maya Lewinsohn's paper, <a href =
"https://www.biorxiv.org/content/10.1101/2022.08.05.502978v1"
class= "minlink">State-dependent evolutionary models reveal modes of solid tumor growth</a>, is now available on BioRxiv.
<li> <b>July 2022: </b> Funding from the <a href =
"https://www.washington.edu/research/research-centers/cystic-fibrosis-research-development-program/"
class = "minlink">Cystic Fibrosis Research Development
Program</a> will support our ongoing work on Pseudomonas
aeruginosa evolution.
<li> <b>June 2022: </b> Elena Romero wins the <a href =
"https://twitter.com/GeneticsGSA/status/1535384373758791680"
class= "minlink">best graduate student
poster award</a> at PEQG 2022 for her work on HIV
recombination! Well done, Elena! Hunter
Colegrove joins the lab as a graduate student, and Dylan Clark
joins the lab as an undergraduate
researchers. Welcome, Dylan,
and welcome back, Hunter!
<li> <b>January 2022: </b> Laura Baquero Galvis joins the lab for a rotation. Welcome, Laura!
<li> <b>December 2021: </b> Funding from the <a href =
"https://researchscholars.gilead.com/en/hiv_portal/award-recipients"
class = "minlink">Gilead
Research Scholars Program in HIV</a> will support our ongoing
work on HIV drug resistance evolution.
<li> <b>October 2021: </b> Hunter Colegrove joins the lab for a
rotation. Welcome, Hunter!
<li> <b>September 2021: </b> Our paper on multi-drug resistance
evolution in HIV is <a href =
"https://elifesciences.org/articles/69032" class =
"minlink">out in eLife</a> (see also the nice <a href =
"https://www.nature.com/articles/s41559-021-01566-1" class = "minlink">highlight</a> in Nature
Eco Evo). Lane Warmbrod from the Institute for
Public Health Genetics joins the lab for a
rotation. Welcome, Lane!
<li> <b>July 2021: </b> Maya Lewinsohn presents her research on
phylodynamic applications in cancer at SMBE 2021. Nice work, Maya!
<li> <b>June 2021: </b> The lab opens in the Genome Sciences
Department at the University of Washington.
Elena Romero joins as the lab's first
graduate student. Welcome, Elena!
</ul>
</DIV>
<DIV id="lab">
<h2> Joining the lab </h2>
<hr>
<h3> Postdoctoral fellows </h3>
The Feder Lab at the University of Washington is hiring postdoctoral fellows. <br><br>
Broadly, the goals of the lab are to understand how spatial structure shapes rapid evolutionary processes, and develop approaches to leverage spatial information to better understand when and how populations will evolve. Within that, we are focusing on two specific research directions:
<ol>
<li>Leveraging phylogenetics to understand tumor evolution and progression through time and space.
<li>Pairing models of viral dynamics and clinical sequencing data to understand the evolution of viral multi-drug resistance evolution in spatially and temporally-heterogeneous environments.
</ol>
As a postdoctoral fellow, you will have the opportunity to
<ol>
<li> Develop your own ideas aligned with the direction of the lab.
<li> Collaborate with other scientists from the lab, the Department of Genome Sciences, the Seattle scientific community and more broadly.
<li> Mentor students at the graduate, undergraduate and high school level
<li> Grow your own research program and plan for the next stages of your career.
</ol>
Potential postdoctoral fellows are very much encouraged to <a
href="#" class="minlink" onclick="contactShow();">get in
touch</a>. Generally the most useful emails will touch on your
background and previous work, how our research interests may
intersect, your timeframe for seeking a position and will include
a copy of your CV. Informal inquiries very welcome. <br>
<hr>
<h3> PhD students </h3>
The lab accepts graduate students through the <a href =
"https://www.gs.washington.edu/academics/gradprogram/index.htm"
class = "minlink">Genome
Sciences</a> and <a href =
"https://mcb-seattle.edu/"
class = "minlink">Molecular and Cellular Biology</a> graduate programs. Prospective graduate students are
very welcome to <a
href="#" class="minlink" onclick="contactShow();">get in touch</a> with
questions about the lab, although this is not required to gain
admittance to the program. Applications are due Dec 1. <br><br>
Currently a grad student in GS or MCB interested in a rotation? Feel free to reach out to chat about project ideas! <br>
<br>
<hr>
<h3> Undergraduate students </h3>
Undergraduate students with an interest in computational biology,
mathematical modeling of biological systems, and/or evolutionary genomics are
encouraged to get in touch regarding potential
projects. Please send an email explaining why you're interested
in the lab's work along with a CV/resume touching on any relevant
experience or coursework (esp. programming) to affeder (at) uw.edu. <br><br>
</DIV>
<DIV id="contact">
<h2>Contact</h2>
<hr>
E-mail: affeder (at) uw.edu<br><br>
We're located in <a href =
"https://www.gs.washington.edu/news/building/index.htm" class =
"minlink">Foege
Hall</a> S103 in the <a href = "https://www.gs.washington.edu/" class =
"minlink">Department of Genome
Sciences</a>. <br><br>
<iframe
src="https://www.google.com/maps/embed?pb=!1m14!1m8!1m3!1d10750.625203500937!2d-122.31667726563721!3d47.65224543616563!3m2!1i1024!2i768!4f13.1!3m3!1m2!1s0x0%3A0x2b7f118ebfa49ee4!2sGenome%20Sciences!5e0!3m2!1sen!2sus!4v1602696642404!5m2!1sen!2sus"
width="400" height="300" frameborder="0" style="border:0;"
allowfullscreen="" aria-hidden="false" tabindex="0"></iframe>
</DIV>
<DIV id="publications">
<h2>Publications</h2>
<hr>
You can find a current and complete list of publications on <a href =
"https://scholar.google.com/citations?user=QZHV8SkAAAAJ&hl=en" class =
"minlink">Google scholar</a>.
<hr>
<img src = "img/papers/fig15.jpg" style="float:left;margin:0 15px 0 0;">
<em> Elevated HIV viral load is associated with higher recombination
rate in vivo (2024)
</em> <br>[<a href =
"https://doi.org/10.1093/molbev/msad260"
class = "minlink">paper in Molecular Biology & Evolution</a>,<br>
<a href =
"https://www.eurekalert.org/news-releases/1030221"
class = "minlink">OUP press release</a>]<br><br> Elena Romero, Alison Feder
<br><br>
<hr>
<img src = "img/papers/fig16.png" style="float:left;margin:0 15px 0 0;">
<em> Brain tropism acquisition: the spatial dynamics and evolution of a measles virus collective infectious unit that drove lethal subacute sclerosing panencephalitis (2023)
</em> [<a href =
"https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011817"
class = "minlink">paper in PLOS Pathogens</a>, Press: <a href =
"https://newsnetwork.mayoclinic.org/discussion/researchers-map-how-measles-virus-spreads-in-human-brain/"
class = "minlink">Mayo news</a>,
<a href =
"https://www.usnews.com/news/health-news/articles/2023-12-26/in-rare-cases-measles-mutates-in-brain-and-kills"
class = "minlink">US News & World Report</a>, <a href =
"https://www.genomeweb.com/sequencing/measles-virus-mutations-found-drive-rare-lethal-brain-infection"
class = "minlink">Genome Web</a>
]<br><br> Iris Yousaf*,
Will Hannon*, Ryan Donohue, Christian Pfaller, Kalpana
Yadav, Ryan Didkan, Sanjay Tyagi, Declan Schroeder, Wun-Ju
Shieh, Paul Rota, Alison Feder, Roberto Cattaneo
<br>
<hr>
<img src = "img/papers/fig14.jpg" style="float:left;margin:0 15px 0 0;">
<em>State-dependent evolutionary models reveal modes of solid tumor
growth (2023)
</em> <br>[<a href =
"https://www.nature.com/articles/s41559-023-02000-4"
class = "minlink">paper in Nature Ecology & Evolution</a>,
<a href =
"https://www.nature.com/articles/s41559-023-01996-z"
class = "minlink">News & Views</a>, <a href =
"https://thisweekmathonco.substack.com/p/this-week-in-mathonco-224" class =
"minlink">This Week in Evolution (TWiEVO),
</a>
<a href =
"https://www.microbe.tv/twievo/twievo-89/" class =
"minlink">This Week in Mathematical Oncology</a>]<br> Maya Lewinsohn, Trevor
Bedford, Nicola Müller*, Alison Feder*
<br>
<hr>
<img src = "img/papers/fig13.jpg" style="float:left;margin:0 15px 0 0;">
<em>Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity
</em> (2021) <br>[<a href =
"https://elifesciences.org/articles/69032" class = "minlink">paper
in eLife</a>, <a href =
"https://www.nature.com/articles/s41559-021-01566-1" class =
"minlink">highlight in Nature
Ecol Evo</a>]<br><br> Alison Feder, Kristin Harper,
Chanson Brumme, Pleuni Pennings
<br><br>
<hr>
<img src = "img/papers/fig11.jpg" style="float:left;margin:0 15px 0 0;">
<br><em>The clarifying role of time series data in the population genetics of HIV </em> (2021) <br> [<a href =
"https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009050" class =
"minlink">paper in PLOS Genetics</a>] <br><br> Alison Feder, Pleuni Pennings, Dmitri Petrov
<br><br>
<hr>
<img src = "img/papers/fig10.jpg" style="float:left;margin:0 15px 0 0;">
<em> Evolutionary dynamics in structured populations under strong
population genetic forces </em> (2019) <br>[<a href =
"https://www.g3journal.org/content/9/10/3395" class = "minlink">paper in G3</a>]<br><br> Alison Feder, Pleuni Pennings, Joachim Hermisson*, Dmitri Petrov*
<br><br>
<hr>
<img src = "img/papers/fig12.jpg" style="float:left;margin:0 15px 0 0;">
<em> The relationship between haplotype-based FST and haplotype length </em> (2019) <br>[<a href = "https://www.genetics.org/content/213/1/281" class = "minlink">paper in Genetics</a>, <a href = "https://www.youtube.com/watch?v=rcPc4J9wh_g" class = "minlink">video abstract</a>]
<br><br> Rohan Mehta, Alison Feder, Simina Boca, Noah Rosenberg
<br><br>
<hr>
<img src = "img/papers/fig8.jpg" style="float:left;margin:0 15px 0 0;">
<em> Within-patient HIV mutation frequencies reveal fitness costs of CpG
dinucleotides, drastic amino acid changes and G->A mutations </em>
(2018) <br>
[<a href =
"http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007420" class = "minlink">paper in PLOS Genetics</a>]
<br><br>
Kristof Theys*, Alison Feder*, Maoz Gelbart*, Marion Hartl, Adi Stern, Pleuni Pennings
<br>
<hr>
<img src = "img/papers/fig9.jpg" style="float:left;margin:0 15px 0 0;">
<em>High resolution spatio-temporal assessment of SHIV evolution reveals a highly dynamic
process within the host </em> (2017) <br>
[<a href =
"http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006358"
class = "minlink">paper in PLOS Pathogens</a>, <a href
= "https://www.youtube.com/watch?v=HVBCLO_IptY" class = "minlink">video
abstract</a>]
<br><br>
Alison Feder, Christopher Kline, Patricia Polacino, Mackenzie
Cottrell, Angela Kashuba, Brandon Keele, Shiu-Lok Hu, Dmitri Petrov, Pleuni Pennings*, Zandrea Ambrose*
<br>
<hr>
<img src = "img/papers/fig6.jpg" style="float:left;margin:0 15px 0 0;">
<em>More effective drugs lead to harder selective sweeps in the evolution
of drug
resistance in
HIV-1</em> (2016)<br> [<a href =
"http://elifesciences.org/content/5/e10670"
class = "minlink">paper in eLife</a>,
<a href =
"https://www.youtube.com/watch?v=43M55F_g9zM&feature=youtu.be"
class = "minlink">video
abstract</a>] <br><br>
Alison Feder, Soo-Yon Rhee, Susan Holmes, Bob Shafer, Dmitri Petrov* and Pleuni Pennings*
<br><br>
<hr>
<img src = "img/papers/fig7.jpg" style="float:left;margin:0 15px 0 0;">
<em>The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens.</em> (2016)<br>
[<a
href = "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943078/" class = "minlink">paper in Molecular Ecology</a>]
<br><br>
Ben Wilson*, Nandita Garud*, Alison Feder*, Zoe Assaf*, and Pleuni Pennings
<br>
<hr>
<img src = "img/papers/fig2.jpg" style="float:left;margin:0 15px 0
0;"><br> <em>Identifying Signatures of Selection in Genetic Time
Series </em> (2014) <br> [<a href = "http://www.ncbi.nlm.nih.gov/pubmed/24318534" class="minlink">paper in Genetics</a>] </li><br><br>
Alison Feder*, Sergey Kryazhimskiy*, Joshua Plotkin<br><br>
<hr>
<img src = "img/papers/fig3.jpg" style="float:left;margin:0 15px 0 0;">
<em>LDx: estimation of linkage disequilibrium from high-throughput pooled resequencing data.</em> <br>
[<a href =
"http://www.ncbi.nlm.nih.gov/pubmed/23152785" class = "minlink">paper in PLOS One</a>, <a href =
"https://sourceforge.net/p/ldx/wiki/Home/" class="minlink">download LDx</a>]</li><br><br>
Alison Feder, Dmitri Petrov, Alan Bergland <br> <br><br>
<hr>
<img src = "img/papers/fig4.jpg" style="float:left;margin:0 15px 0 0;">
<em>Natural selection affects multiple aspects of genetic variation at putatively neutral sites across the human genome. </em> [<a href =
"http://www.ncbi.nlm.nih.gov/pubmed/22022285" class =
"minlink">paper in PLOS Genetics</a>]
</li><br>
<br> Kirk Lohmueller, Anders Albrechtsen, Yingrui Li, Su Yeon Kim,
Thorfinn Korneliussen, Nicolas Vinckenbosch,
Geng Tian, Emilia Huerta-Sanchez, Alison Feder,
Niels Grarup, Torben Jorgensen, Tao Jiang,
Daniel R. Witte, ... , Rasmus Nielsen
<br>
</DIV>
<DIV id="media">
<h2> Media </h2>
<hr>
<ul>
<li>Here's a 15 minute video about some of the lab's interests (Jan 2023):
</ul>
<iframe width="560" height="315" src="https://www.youtube.com/embed/gxSlW2fPtX4" title="Feder lab 15 minute research overview" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe>
<br>
<ul>
<li>Video abstract for 'The Relationship Between Haplotype-Based FST and Haplotype Length':
</ul>
<iframe width="560" height="315" src="https://www.youtube.com/embed/rcPc4J9wh_g" frameborder="0" allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe>
<br>
<ul>
<li>Video abstract for 'A spatio-temporal assessment of simian/human
immunodeficiency virus (SHIV) evolution reveals a highly dynamic process
within the host':
</ul>
<iframe width="560" height="315"
src="https://www.youtube.com/embed/HVBCLO_IptY" frameborder="0"
allowfullscreen></iframe>
<br><br>
<li>Video abstract for 'More efficient drugs lead to harder sweeps in the evolution of drug
resistance in HIV-1':
</ul>
<iframe width="560" height="315"
src="https://www.youtube.com/embed/43M55F_g9zM" frameborder="0"
allowfullscreen></iframe>
</DIV>
<DIV id="people">
<h2>Team</h2>
<hr>
<img src = "img/people/feder.jpg" width = "30%" height = "30%" style="float:left;margin:5px 15px 5px 5px;">
<h3>Alison Feder (she/her)</h3>
Principal investigator
[<a href="afeder_cv.pdf" class="minlink" onClick="ga('send', 'pageview', 'cv.pdf');">CV</a>]<br>
affeder (at) uw.edu<br><br><br><br><br><br>
<hr>
<img src = "img/people/romero.jpg" width = "30%" height = "30%" style="float:left;margin:5px 15px 5px 5px;">
<h3>Elena Romero</h3>
Genome Sciences PhD student<br>
<br>
Elena received her BS in Mathematical and Computational Biology
at Harvey Mudd College. Her work focuses on how HIV's intra-host
demography impacts evolutionary forces like recombination and selection.
<br> <br>
<hr>
<img src = "img/people/colegrove.jpg" width = "30%" height = "30%" style="float:left;margin:5px 15px 5px 5px;">
<h3>Hunter Colegrove</h3>
Genome Sciences PhD student <br> <br>
Hunter received his BA in Biochemistry from the University of
Washington. During his rotation, Hunter developed a pipeline to
call SNVs from spatial transcriptomic data. Now, he is developing
models of cellular competition among epithelial cells. <br>
<hr>
<img src = "img/people/gao.png" width = "30%" height = "30%" style="float:left;margin:5px 15px 5px 5px;">
<h3>Yingnan Gao</h3>
Postdoctoral Fellow <br> <br>
Yingnan received his Ph.D. in Ecology and Evolutionary Biology at University of Virginia. He is currently working on identifying spatial and phylogenetic patterns in tumor through single-cell sequencing data.
<br>
<hr>
<img src = "img/people/robertson.jpg" width = "30%" height = "30%" style="float:left;margin:5px 15px 5px 5px;">
<h3>Alex Robertson</h3>
MCB PhD Student (joint with <a href = "http://kerrlab.org/" class = "minlink">Ben Kerr</a>) <br> <br>
Alex received his BS in Global Disease Biology from UC Davis and his
MPH in Epidemiology of Microbial Diseases from the Yale School of
Public Health. Alex is interested in how intra-cellular interactions
(i.e., among viruses, plasmids) affect evolutionary change at the
population level, particularly with respect to drug resistance.
<br>
<hr>
<img src = "img/people/jia.jpeg" width = "30%" height = "30%" style="float:left;margin:5px 15px 5px 5px;">
<h3>Tongqiu (Iris) Jia</h3>
Genome Sciences Rotation Student <br> <br>
Iris received her BS in Bioinformatics at UC San Diego and MPH in Epidemiology at University of Washington. She is current investigating the dynamics and selection of intra-host Pseudomonas populations.
<br>
<hr>
You? Learn more about <a
href="#" class="minlink" onclick="joinShow();">joining the lab</a>. <br><br>
<h2>Collaborators</h2>
<hr>
<h3>Sam Durfey </h3>
Microbiology PhD Student (Singh lab, UW)<br><br>
Sam is using phylogeography to reconstruct the evolutionary histories of
Pseudomonas aerigunosa lung infections.
<br>
<br>
<h2>Alumni</h2>
<hr>
<!-- = "30%" style="float:left;margin:5px 15px 5px 5px;"> -->
<h3>Nashwa Ahmed</h3>
MCB PhD Rotation Student <br>
<h3>Maya Lewinsohn</h3>
Collaborator/Lab friend <br>
<h3>Dylan Clark</h3>
Undergraduate researcher (Summer 2022 - Fall 2022) <br>
<h3>Laura Baquero Galvis</h3>
MCB PhD rotation student (Winter 2022) <br>
<h3>Lane Warmbrod</h3>
Public Health Genetics PhD rotation student (Fall 2021)<br>
<br>
</DIV>
<DIV id="jc">
<h2> Journal Clubs </h2>
<hr>
We organize two journal clubs focused on the evolution and genomics of cancer and HIV.
<br>
<ul>
<li>Our externally-facing cancer evolution journal club is currently
on hiatus, but our reading list can be found <a
href="https://docs.google.com/spreadsheets/d/1Q4IfEMsGAboWRUwE9lbcHbY5M7mJDcHBPpddfIIsU7A/edit?usp=sharing"
class = "minlink">here</a>.
<li>Our HIV evolution and genomics journal club is organized jointly
with <a href="https://www.fredhutch.org/en/faculty-lab-directory/cohn-lillian.html/" class
= "minlink">Lillie Cohn</a> (Fred Hutch) and <a href="https://dbrvs.org/" class
= "minlink">Dan Reeves</a> (Fred Hutch), and more details can be
found <a
href="https://docs.google.com/spreadsheets/d/1XhdVslzCrcvIa_nD-1_1XsZN7yAHAKchPtsoDYYqoUI/edit?usp=sharing"
class = "minlink">here</a>.
</ul>