Somatic and germline variants

[j0ntt]

Hi,

Does DeepVariant attempt to distinguish germline and somatic variants?

If the VAF of a variant is low, will that mutation be then filtered out or does the tool report only variants of which VAF is close to 0.5 (heterozygous) or 1 (homozygous)?

[danielecook]

@j0ntt you should have a look at google/deepsomatic.

• DeepVariant is a germline caller.
• DeepSomatic is a somatic caller.

DeepSomatic will distinguish between germline and somatic variants.

[j0ntt]

Hi @danielecook

Does this method have a tumor-only mode?

[danielecook]

Currently - no. But we may release a tumor only mode in the future.