These methods have been upgraded into OPNested ComBat (as well as OPNested + GMM and OPNested - GMM ComBat)! You can find the upgraded methods at the OPNested ComBat Github repository! For better performance, check out the new methods and the corresponding publication!
This is the repository for Nested and GMM ComBat from the manuscript entitled "Generalized ComBat Harmonization Methods for Radiomic Features with Multi-modal Distributions and Multiple Batch Effects" by Horng et al., published at Nature Scientific Reports (https://www.nature.com/articles/s41598-022-08412-9).
This file can be imported to use the Nested ComBat function to harmonize by multiple imaging parameters. See file comments for more details.
This file can be imported to use the GMM ComBat function to harmonize by an unknown parameter inferred from the feature distribution to better handle bimodal distributions. See file comments for more details.