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Golgi_Na.channel.nml
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Golgi_Na.channel.nml
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<?xml version="1.0" encoding="ISO-8859-1"?>
<neuroml xmlns="http://www.neuroml.org/schema/neuroml2"
xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.github.com/NeuroML/NeuroML2/development/Schemas/NeuroML2/NeuroML_v2beta4.xsd"
id="GolgiNaT">
<notes>Channel file containing a single Channel description</notes>
<ionChannel id="GolgiNa" conductance="10pS" type="ionChannelHH" species="na">
<notes>Golgi transient Na Channel, based on mod file from E.DAngelo, T.Nieus, A. Fontana. </notes>
<annotation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="GolgiNa">
<bqmodel:isDescribedBy xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
<rdf:Bag>
<rdf:li>S. M. Solinas, L. Forti, E. Cesana, J. Mapelli, E. De Schutter and E. D`Angelo, Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar golgi cells, Frontiers in Cellular Neuroscience 2:2, 2007 </rdf:li>
<rdf:li rdf:resource="https://www.frontiersin.org/articles/10.3389/neuro.03.002.2007/full"/>
</rdf:Bag>
</bqmodel:isDescribedBy>
<bqbiol:isVersionOf xmlns:bqbiol="http://biomodels.net/biology-qualifiers/">
<rdf:Bag>
<rdf:li>Na channels</rdf:li>
<rdf:li rdf:resource="http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table2"/>
</rdf:Bag>
</bqbiol:isVersionOf>
</rdf:Description>
</rdf:RDF>
</annotation>
<gate id="m" type="gateHHratesTau" instances="3">
<q10Settings type="q10ExpTemp" q10Factor="3" experimentalTemp="20 degC"/>
<forwardRate type="HHExpLinearRate" rate="3per_ms" scale="10mV" midpoint="-25mV"/>
<reverseRate type="HHExpRate" rate="12per_ms" scale="-18.182mV" midpoint="-50mV"/>
<timeCourse type="Golgi_NaT_m_tau"/>
<!--q10Settings type="q10ExpTemp" experimentalTemp="20 degC" q10Factor="3"/-->
</gate>
<gate id="h" type="gateHHrates" instances="1">
<q10Settings type="q10ExpTemp" q10Factor="3" experimentalTemp="20 degC"/>
<forwardRate type="HHExpRate" rate="0.21per_ms" scale="-3.333mV" midpoint="-50mV"/>
<reverseRate type="HHSigmoidRate" rate="3per_ms" scale="5mV" midpoint="-17mV"/>
<!--q10Settings type="q10ExpTemp" experimentalTemp="20 degC" q10Factor="3"/-->
</gate>
</ionChannel>
<!--Still doesn't work with channelanalysis -> probably some simulation settings are not ideal for NaT. HG-->
<ComponentType name="Golgi_NaT_m_tau" extends="baseVoltageDepTime">
<Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
<Requirement name="alpha" dimension="per_time"/>
<Requirement name="beta" dimension="per_time"/>
<Dynamics>
<ConditionalDerivedVariable name="t" exposure="t" dimension="time">
<Case condition="(alpha + beta) .lt. ( 0.001 )" value="1000 * TIME_SCALE"/>
<Case condition="1/(alpha + beta) .lt. ( 0.1 )" value="0.1 * TIME_SCALE"/>
<Case value="1/(alpha + beta)"/>
</ConditionalDerivedVariable>
</Dynamics>
</ComponentType>
</neuroml>