README.md

Using modified mendel to calculate penetrance

Program

1. The original version of the program was available at 30d8332

2. We made a single change so that it allows our input data.

3. We compile the code with

gfortran -O3 mendela.f single.f -o single

Data

1. The test data is availabe in data directory.

2. We analyze the data using command

../mendel/single

and choose NO, 21, and no

The output is in single_out.dat.

References

• AJHG 2003, Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations
• Br J Cancer, 2008, The BOADICEA model of genetic susceptibility to breast and ovarian cancers
• NEJM, 2014, Breast-cancer risk in families with mutations in PALB2
• J Clin Onco, 2020, Cancer Risks Associated With Germline PALB2 Pathogenic Variants