isostere_transformations_new.json

[
   {
      "name":"CA_to_CAI1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nn[nH]n1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1NC(=O)NC(=O)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI3-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1ncon1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI3-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1oncn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI4",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1[nH]c(=S)on1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI5-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1ncsn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI5-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1sncn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI6-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)onc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI6-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)on1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI7",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)c(=O)[nH]c(=O)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI10",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(S)[nH]nn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI11",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(F)n[nH]n1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI12",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1](=O)[NH][OH]",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI13",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(=O)NC(=O)C1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI14",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(=O)ccc(=O)c(O)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI15",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(=O)OCOC(O)=1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI16",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][S:1](=O)(=O)[NH]C",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI17",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1](=O)[NH]C#N",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI18-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)noc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI18-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)no1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI19-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)nsc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI19-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)ns1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI20-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)n[nH]c1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI20-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)n[nH]1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI21",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(=O)NC(=O)C=1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI22",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(=O)[NH]C(=O)O1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI23",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(=O)[NH]C(=O)S1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI24-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)cccc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI24-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)ccc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI24-3",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1ccc(O)cc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI25-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)c(Cl)ccc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI25-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)c(Cl)cc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI25-3",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1ccc(O)c(Cl)c1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI25-4",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cccc(O)c(Cl)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI26",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nnc[nH]1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI27",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1[nH]c(=O)on1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI28",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1[nH]s(=O)on1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI29",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1=C(O)C(=O)C(=O)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI30-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c(O)nn(C)c1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI30-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1cc(O)nn(C)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI31",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1[nH]s(=O)(=O)on1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI32",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1n[nH]s(=O)(=O)o1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI33",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nc(O)no1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI34",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nc(O)ns1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI35",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1oc(O)nn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI36",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1oc(S)nn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI37",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1sc(O)nn1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI38-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nc(O)n[nH]1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI38-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][n:1]1nc(O)nc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI39-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1oc(O)nc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI39-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nc(O)oc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI40-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1sc(O)nc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI40-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1nc(O)sc1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI41-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1[NH]C(=O)[NH]C=1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI41-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][N:1]1C(=O)[NH]C=C1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI42-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1[nH]c(=O)[nH]c(=O)c1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI42-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][c:1]1c[nH]c(=O)[nH]c(=O)1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI43",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][S:1](=O)(=O)N",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CA44-1",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1=CC(=O)O[NH]1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CA44-2",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(=O)O[NH]C=1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI45",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1](F)(F)C(=O)[NH][OH]",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI46",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][S:1](=O)(=O)NCCF",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI47",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][S:1](=O)(=O)NCC(F)F",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI48",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][S:1](=O)(=O)NCC(F)(F)F",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI49",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1(O)COC1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI50",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1](O)C(F)(F)F",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI51",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1](O)(C(F)(F)F)C(F)(F)F",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"CA_to_CAI52",
      "smarts":"[#6:2][#6:1](=O)[O;-,H1]>>[*:2][C:1]1C(O)=CC(=O)C1",
      "tags":[
         "Acid Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI1",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C1(COC1)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI2",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C1(CC(F)(F)C1)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI3",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]S(=O)(=[N;H1])[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI4",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(F)(F)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI5",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(F)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI6",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(=C(F)F)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI7",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(=C(C#N)C#N)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI8",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(=C(C#N)C#N)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI9",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(=CC#N)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI10",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C(C(F)(F)F)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI11",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C1(CCC1)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI12",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C1(CC1)[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI13",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]C1OCC1[#6:2]",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI14",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]-C1OCC(-[#6:2])C1",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Ketone_to_KI15",
      "smarts":"[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):1][C;!R](=O)[$([#6]);!$([#6]=[C,O,N,S]);!$([#6]-[O,N,S]):2]>>[#6:1]-c1occ(-[#6:2])c1",
      "tags":[
         "Isostere",
         "Ketone Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI1-1",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C1CCC1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI1-14",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1]c(-[*;!#1:2])[c;H1][c;H1]1>>[*:1]C1CC([*:2])C1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI2-1",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C12C3C4C1C1C2C3C41",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI2-14",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1]c(-[*;!#1:2])[c;H1][c;H1]1>>[*:1]C12C3C4C1C1C2C3C([*:2])41",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI3-1",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C1CCCCC1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI3-14",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1]c(-[*;!#1:2])[c;H1][c;H1]1>>[*:1]C1CCC([*:2])CC1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI4-1",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C12CC(C2)C1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI4-14",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1]c(-[*;!#1:2])[c;H1][c;H1]1>>[*:1]C12CC([*:2])(C2)C1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI5-1",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C12CCC(CC2)CC1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI5-14",
      "smarts":"[*;!#1:1]c1[c;H1][c;H1]c([*;!#1:2])[c;H1][c;H1]1>>[*:1]C12CCC([*:2])(CC2)CC1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI6-1",
      "smarts":"[*;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C1CC2CC2C1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI6-14",
      "smarts":"[*;!#1:1]c1[c;H1][c;H1]c([*;!#1:2])[c;H1][c;H1]1>>[*:1]C1CC2C([*:2])C2C1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI7-1",
      "smarts":"[*;!#1:1]-[c:2]1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1][c:2]1ncccc1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI7-12",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c:4][c:5][c:6][c:7](-[*;!#1:2])1>>[*:1][c:3]1n[c:4][c:5][c:6][c:7]([*:2])1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI7-13",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c:4](-[*;!#1:2])[c:5][c:6][c:7]1>>[*:1][c:3]1n[c:4]([*:2])[c:5][c:6][c:7]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI7-14",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c:4][c:5](-[*;!#1:2])[c:6][c:7]1>>[*:1][c:3]1n[c:4][c:5]([*:2])[c:6][c:7]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_P8-1",
      "smarts":"[*;!#1:1]-[c:2]1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1][c:2]1ncccn1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_P8-13",
      "smarts":"[*;!#1:1][c:3]1[c;H1][c:4]([*;!#1:2])[c:5][c:6][c;H1]1>>[*:1][c:3]1n[c:4]([*:2])[c:5][c:6]n1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_P8-14",
      "smarts":"[*;!#1:1][c:3]1[c;H1][c:4][c:5]([*;!#1:2])[c:6][c;H1]1>>[*:1][c:3]1n[c:4][c:5]([*:2])[c:6]n1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI9-1",
      "smarts":"[*;!#1:1]-[c:2]1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]c1nnccc1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI9-12",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c;H1][c:4][c:5][c:6](-[*;!#1:2])1>>[*:1][c:3]1nn[c:4][c:5][c:6]([*:2])1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI9-13",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c;H1][c:4][c:5](-[*;!#1:2])[c:6]1>>[*:1][c:3]1nn[c:4][c:5]([*:2])[c:6]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI9-14",
      "smarts":"[*;!#1:1][c:3]1[c;H1][c;H1][c:4]([*;!#1:2])[c:5][c:6]1>>[*:1][c:3]1nn[c:4]([*:2])[c:5][c:6]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI10-1",
      "smarts":"[*;!#1:1]-[c:2]1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]-[c:2]1nccnc1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI10-12",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c:4][c:5][c;H1][c:6](-[*;!#1:2])1>>[*:1][c:3]1n[c:4][c:5]n[c:6]([*:2])1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI10-13",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c:4](-[*;!#1:2])[c:5][c;H1][c:6]1>>[*:1][c:3]1n[c:4]([*:2])[c:5]n[c:6]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI10-14",
      "smarts":"[*;!#1:1]-[c:3]1[c;H1][c:4][c:5](-[*;!#1:2])[c;H1][c:6]1>>[*:1][c:3]1n[c:4][c:5]([*:2])n[c:6]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI11-1",
      "smarts":"[*;!#1:1]-[c:2]1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1][c:2]1sccc1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI11-12",
      "smarts":"[*;!#1:1][c:3]1[c:4]([*;!#1:2])[c:5][c:6][c;H1][c;H1]1>>[*:1][c:3]1s[c:6][c:5][c:4]([*:2])1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI11-13",
      "smarts":"[*;!#1:1][c:3]1[c:4][c:5]([*;!#1:2])[c:6][c;H1][c;H1]1>>[*:1][c:3]1s[c:6][c:5]([*:2])[c:4]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI11-14",
      "smarts":"[*;!#1:1][c:3]1[c:4][c:5][c:6]([*;!#1:2])[c;H1][c;H1]1>>[*:1][c:3]1s[c:6]([*:2])[c:5][c:4]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI12-1",
      "smarts":"[*;!#1:1]-[c:2]1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1][c:2]1scnc1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI12-12",
      "smarts":"[*;!#1:1]-[c:3]1[c:4](-[*;!#1:2])[c;H1][c:6][c;H1][c;H1]1>>[*:1][c:3]1s[c:6]n[c:4]([*:2])1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI12-14",
      "smarts":"[*;!#1:1]-[c:3]1[c:4][c;H1][c:6](-[*;!#1:2])[c;H1][c;H1]1>>[*:1][c:3]1s[c:6]([*:2])n[c:4]1",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI13-1",
      "smarts":"[c,C;!#1:1]-c1[c;H1][c;H1][c;H1][c;H1][c;H1]1>>[*:1]C#C",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"Phenyl_to_PI13-14",
      "smarts":"[c,C;!#1:1]-c1[c;H1][c;H1]c(-[c,C;!#1:2])[c;H1][c;H1]1>>[*:1]C#C[*:2]",
      "tags":[
         "Isostere",
         "Phenyl Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI1",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C(N)1COC1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI2",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]S(=O)(=O)N",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI3",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C(C(F)(F)F)N",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI4",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C1(CC1)N",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI5",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1nnco1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI6",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1[nH]nnc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI7",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1nnc[nH]1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI8",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1[nH]nnn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI9",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1ncno1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI10",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1cnco1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI11",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1cocn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI12",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C(C(F)F)N",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI13",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C(F)=C",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI14",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1nocn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI15",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1occn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI16",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C(=N)N",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI17",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]C(=NC)N",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI18",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1nnccc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI19",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1cnncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI20",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1nccnc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI21",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1ncccn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI22",
      "smarts":"[c,C:1][C;!R](=O)[N;H2]>>[*:1]c1cncnc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI23",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])oc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI24",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])[nH]c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI25",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])n(C)c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI26",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])n[nH]1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI27",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])nn(C)1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI28",
      "smarts":"[#6;H2,H3:1][#6;H2:2]C(=O)[N;H2]>>[c:1]1[n:2]c([N;H2])[nH]c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI29",
      "smarts":"[#6;H2,H3:1][#6;H2:2]C(=O)[N;H2]>>[c:1]1[n:2]c([N;H2])ncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI30",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])ncn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI31",
      "smarts":"[#6;H2,H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[c:1]1[c:2]c([N;H2])nnc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"nsAmide_to_nsAI32",
      "smarts":"[#6;H3:1][#6;H1,H2:2]C(=O)[N;H2]>>[n:1]1[c:2]c([N;H2])ncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Unsubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI1",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C(N[*:2])1COC1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI2",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]S(=O)(=O)N[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI3",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C(C(F)(F)F)N[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI4",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C1(CC1)N[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI5",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nnc([*:2])o1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI6",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nnn([*:2])c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI7",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nnc([*:2])[nH]1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI8",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nnn([*:2])n1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI9",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nc([*:2])no1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI10",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1cnc([*:2])o1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI11",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1coc([*:2])n1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI12",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C(C(F)F)N[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI13",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C(F)=C[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI14",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1noc([*:2])n1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI15",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1occ([*:2])n1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI16",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1ncc([*:2])o1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI17",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C(=N)N[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI18",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]C(=NC)N[*:2]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI19",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nnc([*:2])cc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI20",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1nncc([*:2])c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI21",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1ncc([*:2])nc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI22",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H1;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])][c,C:2]>>[*:1]c1c([*:2])nccn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI23",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[#6:3])oc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI24",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[*:3])[nH]c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI25",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[*:3])n(C)c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI26",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[*:3])n[nH]1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI27",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[*:3])nn(C)1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI28",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[n:2]c(N[*:3])nc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI29",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[n:2]c(N[*:3])ncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI30",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[*:3])ncn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI31",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[c:1]1[c:2]c(N[*:3])nnc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"msAmide_to_msAI32",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2]C(=O)[$(N);H1;!$(N([C,S]=[O,S])[C,S]=[O,S])][#6:3]>>[n:1]1[c:2]c(N[*:3])ncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Monosubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI1",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C(N([*:2])[*:3])1COC1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI2",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]S(=O)(=O)N([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI3",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C(C(F)(F)F)N([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI4",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C1(CC1)N([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI5",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C(C(F)F)N([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI6",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C(F)=C([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI7",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C(=N)N([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI8",
      "smarts":"[c,C:1][C;!R](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S])]([c,C:2])[c,C:3]>>[*:1]C(=NC)N([*:2])[*:3]",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI9",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])oc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI10",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])[nH]c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI11",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])n(C)c1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI12",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])n[nH]1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI13",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])nn(C)1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI14",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[n:2][c:3]([N:4]([*:5])[*:6])nc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI15",
      "smarts":"[#6;H2,H3:1][#6;H2:2][#6:3](=O)[$(N);H0;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[n:2][c:3]([N:4]([*:5])[*:6])ncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI16",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])ncn1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI17",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R:4]([c,C:5])[c,C:6]>>[c:1]1[c:2][c:3]([N:4]([*:5])[*:6])nnc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"dsAmide_to_dsAI18",
      "smarts":"[#6;H2,H3:1][#6;H1,H2;!$([#6]~[#7,#8,#16]):2][#6;!R:3](=O)[$(N);H0;!R;!$(N([C,S]=[O,S])[C,S]=[O,S]):4]([c,C:5])[c,C:6]>>[n:1]1[c:2][c:3]([N:4]([*:5])[*:6])ncc1",
      "tags":[
         "Amide Isostere",
         "Isostere",
         "Disubstituted Amide Isostere"
      ]
   },
   {
      "name":"Ester_to_EI1",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][C:3]1(COC1)O[*:4]",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ester_to_EI2",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][c:3]1c(O[*:4])noc1",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ester_to_EI3",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][c:3]1c(O[*:4])onc1",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ester_to_EI4",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][c:3]1c(O[*:4])nco1",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ester_to_EI5",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][c:3]1c(O[*:4])ocn1",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ester_to_EI6",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][C:3](C#N)=NO[*:4]",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Ester_to_EI7",
      "smarts":"[*:1][c,C:2][C:3](=O)[O;!H1,!-][c,C:4]>>[*:1][*:2][C:3](C(F)(F)F)O[*:4]",
      "tags":[
         "Ester Isostere",
         "Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI1",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1COC1",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI2",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1(COC1)F",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI3",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1(COC1)C",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI4",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1(COC1)C(F)(F)F",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI5",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1CC1",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI6",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1(CC1)F",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI7",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1(CC1)C",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI8",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]C1(CC1)C(F)(F)F",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI9",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1][#14](C)(C)C",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Tbutyl_to_TBI10",
      "smarts":"[c,C:1]C([C;H3])([C;H3])[C;H3]>>[*:1]S(F)(F)(F)(F)F",
      "tags":[
         "Isostere",
         "T-butyl Isostere"
      ]
   },
   {
      "name":"Drop_CH2",
      "smarts":"[*:1][CH2][*:2]>>[*:1][*:2]",
      "tags":[
         "Drop C"
      ]
   },
   {
      "name":"Drop_CH2CH2",
      "smarts":"[*:1][CH2][CH2][*:2]>>[*:1][*:2]",
      "tags":[
         "Drop C"
      ]
   },
   {
      "name":"Drop_CH2CH2CH2",
      "smarts":"[*:1][CH2][CH2][CH2][*:2]>>[*:1][*:2]",
      "tags":[
         "Drop C"
      ]
   },
   {
      "name":"Drop_CH3",
      "smarts":"[*:1][CH3]>>[*:1]",
      "tags":[
         "Drop C"
      ]
   },
   {
      "name":"Drop_CH2CH3",
      "smarts":"[*:1][CH2][CH3]>>[*:1]",
      "tags":[
         "Drop C"
      ]
   },
   {
      "name":"Drop_CH2CH2CH3",
      "smarts":"[*:1][CH2][CH2][CH3]>>[*:1]",
      "tags":[
         "Drop C"
      ]
   },
   {
      "name":"Add_CH2",
      "smarts":"[*:1]-[*:2]>>[*:1]C[*:2]",
      "tags":[
         "Add C"
      ]
   },
   {
      "name":"Add_CH2CH2",
      "smarts":"[*:1]-[*:2]>>[*:1]CC[*:2]",
      "tags":[
         "Add C"
      ]
   },
   {
      "name":"Add_CH2CH2CH2",
      "smarts":"[*:1]-[*:2]>>[*:1]CCC[*:2]",
      "tags":[
         "Add C"
      ]
   },
   {
      "name":"Add_CH3",
      "smarts":"[*h:1]>>[*:1]C",
      "tags":[
         "Add C"
      ]
   },
   {
      "name":"Add_CH2CH3",
      "smarts":"[*h:1]>>[*:1]CC",
      "tags":[
         "Add C"
      ]
   },
   {
      "name":"Add_CH2CH2CH3",
      "smarts":"[*h:1]>>[*:1]CCC",
      "tags":[
         "Add C"
      ]
   }
]