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Project Marilyn Timeline

January 2014

  • Crowdfunding launch (January 7th)

February 2014

February 7th: crowdfunding ends, unless extended up to two weeks depending on stretch goal status

  • Negotiate space requirements.
  • 3rd week: indysci dot org Board Meeting (first board meeting after fundraising) Vote on making board meetings biannual moving forward, or dissolution of indysci if fundraising fails.

March 2014

  • Hires have moved to San Diego.
  • First meeting with outside advisor.
  • Begin paying hires.

July 2014

  • Complete modifications for Chemistry hood
  • Complete evaluation of species (M. smegmatis; S. avermitilis) for synthetic bio work
  • Complete evaluation of S. sibiricum for continued work

December 2014

  • Complete chemical evaluation for production of anthranilic acid analogs
  • Complete evaluation of strains (B. subtilis, S. cerevesiae) for bioassay work
  • Complete synthetic biology
  • Begin evolution on selected strains for yield improvement.

March 2015

  • Meeting with outside advisor. Go/no go; evaluation of likelihood of success in remaining timeframe.

July 2015

  • Negotiation with CROs for services
  • Begin scaleup of all compounds
  • Shipment of new compounds to NCI/60 cancer cell line panel

September 2015

  • Conclusion of Project Marilyn labwork. Shipment of compounds to CROs for evaluation.

(remainder of the time is general “flex-time” to account for experimental difficulties).

March 2016

  • Project Marilyn concluded.
  • Final meeting with outside adivsor. Evaluation of success condition or, go/no go to attempt to complete objectives with remaining funds.

Disbursal of remaining funds to selected 501(c)(3) hospital, and Project Marilyn stretch goals, if applicable.