Selection On PRotein ANnotated regiOns
This can be accessed via the webserver: soprano-app
The SOPRANO method was developed to quantify selection in specific regions of the genome. It calculates ON- and OFF-target dN/dS using a set of annotated somatic point mutations and a transcript coordinates file.
This repository is a Python reimplementation of the original method with two main offerings:
- An application interface to easily pre-process the relevant input files.
- A scalable command line utility to run the SOPRANO pipeline for dN/dS, serving local and high-performance computing environments, distributed over MPI.
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Documentation is available on this site.
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Issues should be raised here.
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Reference the SOPRANO method with Zapata et al.
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View the original repository here.