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AE017046.embl
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AE017046.embl
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ID AE017046; SV 1; circular; genomic DNA; STD; PRO; 9609 BP.
XX
AC AE017046;
XX
DT 12-MAR-2004 (Rel. 79, Created)
DT 14-NOV-2006 (Rel. 89, Last updated, Version 5)
XX
DE Yersinia pestis biovar Microtus str. 91001 plasmid pPCP1, complete
DE sequence.
XX
KW .
XX
OS Yersinia pestis biovar Microtus str. 91001
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC Enterobacteriaceae; Yersinia.
OG Plasmid pPCP1
XX
RN [1]
RP 1-9609
RX DOI; 10.1093/dnares/11.3.179.
RX PUBMED; 15368893.
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans";
RL DNA Res. 11(3):179-197(2004).
XX
RN [2]
RP 1-9609
RX DOI; 10.1128/JB.186.15.5147-5152.2004.
RX PUBMED; 15262951.
RA Zhou D., Tong Z., Song Y., Han Y., Pei D., Pang X., Zhai J., Li M., Cui B.,
RA Qi Z., Jin L., Dai R., Du Z., Wang J., Guo Z., Wang J., Huang P., Yang R.;
RT "Genetics of metabolic variations between Yersinia pestis biovars and the
RT proposal of a new biovar, microtus";
RL J. Bacteriol. 186(15):5147-5152(2004).
XX
RN [3]
RP 1-9609
RA Song Y., Tong Z., Wang L., Han Y., Zhang J., Pei D., Wang J., Zhou D.,
RA Han Y., Pang X., Zhai J., Chen F., Qin H., Wang J., Li S., Guo Z., Ye C.,
RA Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.;
RT ;
RL Submitted (24-APR-2003) to the EMBL/GenBank/DDBJ databases.
RL The Institute of Microbiology and Epidemiology, Academy of Military Medical
RL Sciences, No. 20, Dongdajie Street, Fengtai District, Beijing 100071,
RL People's Republic of China
XX
DR GR; AE017046_GR.
DR RFAM; RF00106; RNAI.
XX
FH Key Location/Qualifiers
FH
FT source 1..9609
FT /organism="Yersinia pestis biovar Microtus str. 91001"
FT /plasmid="pPCP1"
FT /strain="91001"
FT /mol_type="genomic DNA"
FT /note="biovar: Microtus"
FT /db_xref="taxon:229193"
FT repeat_region 1..1954
FT /mobile_element="insertion sequence:IS100"
FT gene 87..1109
FT /locus_tag="YP_pPCP01"
FT /old_locus_tag="pPCP01"
FT CDS 87..1109
FT /codon_start=1
FT /transl_table=11
FT /locus_tag="YP_pPCP01"
FT /old_locus_tag="pPCP01"
FT /product="putative transposase"
FT /note="similar to corresponding CDS from previously
FT sequenced pPCP plasmid of Yersinia pestis KIM (AF053945)
FT and CO92 (AL109969), also many transposase entries for
FT insertion sequence IS100 of Yersinia pestis. Contains
FT IS21-like element transposase, HTH domain
FT (Interpro|IPR007101)"
FT /db_xref="GOA:Q7ARN5"
FT /db_xref="InterPro:IPR017894"
FT /db_xref="UniProtKB/TrEMBL:Q7ARN5"
FT /protein_id="AAS58758.1"
FT /translation="MVTFETVMEIKILHKQGMSSRAIARELGISRNTVKRYLQAKSEPP
FT KYTPRPAVASLLDEYRDYIRQRIADAHPYKIPATVIAREIRDQGYRGGMTILRAFIRSL
FT SVPQEQEPAVRFETEPGRQMQVDWGTMRNGRSPLHVFVAVLGYSRMLYIEFTDNMRYDT
FT LETCHRNAFRFFGGVPREVLYDNMKTVVLQRDAYQTGQHRFHPSLWQFGKEMGFSPRLC
FT RPFRAQTKGKVERMVQYTRNSFYIPLMTRLRPMGITVDVETANRHGLRWLHDVANQRKH
FT ETIQARPCDRWLEEQQSMLALPPEKKEYDVHLDENLVNFDKHPLHHPLSIYDSFCRGVA
FT "
FT gene 1106..1888
FT /locus_tag="YP_pPCP02"
FT /old_locus_tag="pPCP02"
FT CDS 1106..1888
FT /codon_start=1
FT /transl_table=11
FT /locus_tag="YP_pPCP02"
FT /old_locus_tag="pPCP02"
FT /product="putative ATP-binding protein"
FT /note="similar to corresponding CDS form previously
FT sequenced pPCP plasmid of Yersinia pestis KIM (AF053945)
FT and CO92 (AL109969), also many ATP-binding protein entries
FT for insertion sequence IS100 of Yersinia pestis. Contains
FT Chaperonin clpA/B (Interpro|IPR001270). Contains
FT ATP/GTP-binding site motif A (P-loop) (Interpro|IPR001687,
FT Molecular Function: ATP binding (GO:0005524)). Contains
FT Bacterial chromosomal replication initiator protein, DnaA
FT (Interpro|IPR001957, Molecular Function: DNA binding
FT (GO:0003677), Molecular Function: DNA replication origin
FT binding (GO:0003688), Molecular Function: ATP binding
FT (GO:0005524), Biological Process: DNA replication
FT initiation (GO:0006270), Biological Process: regulation of
FT DNA replication (GO:0006275)). Contains AAA ATPase
FT (Interpro|IPR003593, Molecular Function: nucleotide binding
FT (GO:0000166))"
FT /db_xref="GOA:Q7ARK4"
FT /db_xref="InterPro:IPR003593"
FT /db_xref="UniProtKB/TrEMBL:Q7ARK4"
FT /protein_id="AAS58759.1"
FT /translation="MMMELQHQRLMALAGQLQLESLISAAPALSQQAVDQEWSYMDFLE
FT HLLHEEKLARHQRKQAMYTRMAAFPAVKTFEEYDFTFATGAPQKQLQSLRSLSFIERNE
FT NIVLLGPSGVGKTHLAIAMGYEAVRAGIKVRFTTAADLLLQLSTAQRQGRYKTTLQRGV
FT MAPRLLIIDEIGYLPFSQEEAKLFFQVIAKRYEKSAMILTSNLPFGQWDQTFAGDAALT
FT SAMLDRILHHSHVVQIKGESYRLRQKRKAGVIAEANPE"
FT gene 2925..3119
FT /gene="rop"
FT /locus_tag="YP_pPCP03"
FT /old_locus_tag="pPCP03"
FT /note="synonym: rom"
FT CDS 2925..3119
FT /codon_start=1
FT /transl_table=11
FT /gene="rop"
FT /locus_tag="YP_pPCP03"
FT /old_locus_tag="pPCP03"
FT /product="putative replication regulatory protein"
FT /note="Best Blastp hit =gi|16082682|ref|NP_395229.1|
FT (NC_003132) putative replication regulatory protein
FT [Yersinia pestis], gi|5763813|emb|CAB531 66.1| (AL109969)
FT putative replication regulatory protein [Yersinia pestis];
FT similar to gb|AAK91579.1| (AY048853), RNAI modulator
FT protein Rom [Salmonella choleraesuis], Contains Regulatory
FT protein Rop (Interpro|IPR000769)"
FT /db_xref="HSSP:1ROP"
FT /db_xref="InterPro:IPR000769"
FT /db_xref="UniProtKB/TrEMBL:Q9S1E1"
FT /protein_id="AAS58760.1"
FT /translation="MNKQQQTALNMARFIRSQSLILLEKLDALDADEQAAMCERLHELA
FT EELQNSIQARFEAESETGT"
FT gene 3486..3857
FT /locus_tag="YP_pPCP04"
FT /old_locus_tag="pPCP04"
FT CDS 3486..3857
FT /codon_start=1
FT /transl_table=11
FT /locus_tag="YP_pPCP04"
FT /old_locus_tag="pPCP04"
FT /product="conserved hypothetical protein"
FT /note="Best Blastp hit = gi|321919|pir||JQ1541 hypothetical
FT 16.9K protein - Salmonella typhi murium plasmid NTP16."
FT /db_xref="UniProtKB/TrEMBL:Q74YE8"
FT /protein_id="AAS58761.1"
FT /translation="MSKKRRPQKRPRRRRFFHRLRPPDEHHKNRRSSQRWRNPTGLKDT
FT RRFPPEAPSCALLFRPCRLPDTSPPFSLREAWRFLIAHAVGISVRCRSFAPSWAVCTNP
FT PFSPTTAPYPVTIVLSPTR"
FT misc_feature 3498..3626
FT /locus_tag="YP_pPCP04"
FT /old_locus_tag="pPCP04"
FT /note="ProfileScan match to entry PS50323 ARG_RICH, E-value
FT 8.981"
FT gene 4343..4780
FT /gene="pim"
FT /locus_tag="YP_pPCP05"
FT /old_locus_tag="pPCP05"
FT CDS 4343..4780
FT /codon_start=1
FT /transl_table=11
FT /gene="pim"
FT /locus_tag="YP_pPCP05"
FT /old_locus_tag="pPCP05"
FT /product="pesticin immunity protein"
FT /note="similar to many previously sequenced pesticin
FT immunity protein entries of Yersinia pestis plasmid pPCP,
FT e.g. gi| 16082683|,ref|NP_395230.1| (NC_003132) ,
FT gi|1200166|emb|CAA90861.1| (Z54145 ) , gi|1488655|
FT emb|CAA63439.1| (X92856) , gi|2996219|gb|AAC62543.1|
FT (AF053945) , and gi|5763814|emb|CAB531 67.1| (AL109969)"
FT /db_xref="UniProtKB/TrEMBL:Q74YE7"
FT /protein_id="AAS58762.1"
FT /translation="MGGGMISKLFCLALIFLSSSGLAEKNTYTAKDILQNLELNTFGNS
FT LSHGIYGKQTTFKQTEFTNIKSNTKKHIALINKDNSWMISLKILGIKRDEYTVCFEDFS
FT LIRPPTYVAIHPLLIKKVKSGNFIVVKEIKKSIPGCTVYYH"
FT gene complement(4815..5888)
FT /gene="pst"
FT /locus_tag="YP_pPCP06"
FT /old_locus_tag="pPCP06"
FT CDS complement(4815..5888)
FT /codon_start=1
FT /transl_table=11
FT /gene="pst"
FT /locus_tag="YP_pPCP06"
FT /old_locus_tag="pPCP06"
FT /product="pesticin"
FT /note="Best Blastp hit =|16082684|ref|NP_395231.1|
FT (NC_003132) pesticin [Yersinia pestis],
FT gi|984824|gb|AAA75369.1| (U31974) pesticin [Yersinia
FT pestis], gi|1488654|emb|CAA63438.1| (X92856) pesticin
FT [Yersinia pestis], gi|2996220|gb|AAC62544.1| (AF053945)
FT pesticin [Yersinia pestis], gi|5763815|emb|CAB53168.1|
FT (AL1099 69) pesticin [Yersinia pestis]"
FT /db_xref="UniProtKB/TrEMBL:Q57159"
FT /protein_id="AAS58763.1"
FT /translation="MSDTMVVNGSGGVPAFLFSGSTLSSYRPNFEANSITIALPHYVDL
FT PGRSNFKLMYIMGFPIDTEMEKDSEYSNKIRQESKISKTEGTVSYEQKITVETGQEKDG
FT VKVYRVMVLEGTIAESIEHLDKKENEDILNNNRNRIVLADNTVINFDNISQLKEFLRRS
FT VNIVDHDIFSSNGFEGFNPTSHFPSNPSSDYFNSTGVTFGSGVDLGQRSKQDLLNDGVP
FT QYIADRLDGYYMLRGKEAYDKVRTAPLTLSDNEAHLLSNIYIDKFSHKIEGLFNDANIG
FT LRFSDLPLRTRTALVSIGYQKGFKLSRTAPTVWNKVIAKDWNGLVNAFNNIVDGMSDRR
FT KREGALVQKDIDSGLLK"
FT variation 5910..5911
FT /replace=""
FT /note="compared to AF053945"
FT variation 5933^5934
FT /replace="a"
FT /note="compared to AL109969"
FT variation 5933^5934
FT /replace="aa"
FT /note="compared to AF053945"
FT variation 5948
FT /replace="c"
FT /note="compared to AL109969"
FT gene 6005..6421
FT /locus_tag="YP_pPCP07"
FT /old_locus_tag="pPCP07"
FT CDS 6005..6421
FT /codon_start=1
FT /transl_table=11
FT /locus_tag="YP_pPCP07"
FT /old_locus_tag="pPCP07"
FT /product="conserved hypothetical proteins"
FT /note="Best Blastp hit = gi|16082685|ref|NP_395232.1|
FT (NC_003132) hypothetical protein [Yersinia pestis],
FT gi|5763816|emb|CAB53169.1| (AL109969) hypothetical protein
FT [Yersinia pestis]"
FT /db_xref="UniProtKB/TrEMBL:Q9S1E0"
FT /protein_id="AAS58764.1"
FT /translation="MKFHFCDLNHSYKNQEGKIRSRKTAPGNIRKKQKGDNVSKTKSGR
FT HRLSKTDKRLLAALVVAGYEERTARDLIQKHVYTLTQADLRHLVSEISNGVGQSQAYDA
FT IYQARRIRLARKYLSGKKPEGVEPREGQEREDLP"
FT variation 6525
FT /replace="c"
FT /note="compared to AF053945 and AL109969"
FT gene 6664..7602
FT /gene="pla"
FT /locus_tag="YP_pPCP08"
FT /old_locus_tag="pPCP08"
FT CDS 6664..7602
FT /codon_start=1
FT /transl_table=11
FT /gene="pla"
FT /locus_tag="YP_pPCP08"
FT /old_locus_tag="pPCP08"
FT /product="plasminogen activator"
FT /note="similar to many previosly sequenced
FT coagulase/fibrinolysin precursor (plasminogen activator )
FT of Yersinia pestis plasmid pPCP from difference strains,
FT e.g. gi|16082686|ref|NP_395233.1| , gi|116897|sp|P17811|,
FT gi|96995|pir||A30916 , gi|48630|emb|CAA33235.1| ( X15136),
FT gi|2996221|gb|AAC62545.1| (AF053945),and
FT gi|5763817|emb|CAB53170.1| (AL109969 ); The 279th aa is T
FT (Thr) in reference entries, and in this sequence it is
FT I(Ile). Contains Omptin serine protease
FT (Interpro|IPR000036, Biological Process: proteolysis and
FT peptidolysis (GO:0006508), Molecular Function: serine-type
FT peptidase (GO:0008236), Cellular Component: external outer
FT membrane (sensu Gram-negative Bacteria) (GO:0009279))"
FT /db_xref="GOA:P17811"
FT /db_xref="HSSP:1I78"
FT /db_xref="InterPro:IPR001702"
FT /db_xref="UniProtKB/Swiss-Prot:P17811"
FT /protein_id="AAS58765.1"
FT /translation="MKKSSIVATIITILSGSANAASSQLIPNISPDSFTVAASTGMLSG
FT KSHEMLYDAETGRKISQLDWKIKNVAILKGDISWDPYSFLTLNARGWTSLASGSGNMDD
FT YDWMNENQSEWTDHSSHPATNVNHANEYDLNVKGWLLQDENYKAGITAGYQETRFSWTA
FT TGGSYSYNNGAYTGNFPKGVRVIGYNQRFSMPYIGLAGQYRINDFELNALFKFSDWVRA
FT HDNDEHYMRDLTFREKTSGSRYYGTVINAGYYVTPNAKVFAEFTYSKYDEGKGGTQIID
FT KNSGDSVSIGGDAAGISNKNYTVTAGLQYRF"
FT gene complement(7789..8088)
FT /locus_tag="YP_pPCP09"
FT /old_locus_tag="pPCP09"
FT CDS complement(7789..8088)
FT /codon_start=1
FT /transl_table=11
FT /locus_tag="YP_pPCP09"
FT /old_locus_tag="pPCP09"
FT /product="putative transcriptional regulator"
FT /note="Best Blastp hit = gi|16082687|ref|NP_395234.1|
FT (NC_003132) putative transcriptional regulator [Yersinia
FT pestis], gi|5763818|emb|CAB53171.1| (AL109969) putative
FT transcriptional regulator [Yersinia pestis]."
FT /db_xref="GOA:Q9S1D9"
FT /db_xref="InterPro:IPR001387"
FT /db_xref="UniProtKB/TrEMBL:Q9S1D9"
FT /protein_id="AAS58766.1"
FT /translation="MRTLDEVIASRSPESQTRIKEMADEMILEVGLQMMREELQLSQKQ
FT VAEAMGISQPAVTKLEQRGNDLKLATLKRYVEAMGGKLSLDVELPTGRRVAFHV"
FT gene complement(8088..8360)
FT /locus_tag="YP_pPCP10"
FT /old_locus_tag="pPCP10"
FT CDS complement(8088..8360)
FT /codon_start=1
FT /transl_table=11
FT /locus_tag="YP_pPCP10"
FT /old_locus_tag="pPCP10"
FT /product="conserved hypothetical protein"
FT /note="Best Blastp hit = gi|16082688|ref|NP_395235.1|
FT (NC_003132) hypothetical protein [ Yersinia pestis],
FT gi|5763819|emb|CAB53172.1| (AL109969) hypothetical protein
FT [Yersinia pestis]"
FT /db_xref="UniProtKB/TrEMBL:Q74YE3"
FT /protein_id="AAS58767.1"
FT /translation="MADLKKLQVYGPELPRPYADTVKGSRYKNMKELRVQFSGRPIRAF
FT YAFDPIRRAIVLCAGDKSNDKRFYEKLVRIAEDEFTAHLNTLESK"
FT variation 8529^8530
FT /replace="tt"
FT /note="compared to AL109969"
XX
SQ Sequence 9609 BP; 2792 A; 2250 C; 2099 G; 2468 T; 0 other;
tgtaacgaac ggtgcaatag tgatccacac ccaacgcctg aaatcagatc cagggggtaa 60
tctgctctcc tgattcagga gagtttatgg tcacttttga gacagttatg gaaattaaaa 120
tcctgcacaa gcagggaatg agtagccggg cgattgccag agaactgggg atctcccgca 180
ataccgttaa acgttatttg caggcaaaat ctgagccgcc aaaatatacg ccgcgacctg 240
ctgttgcttc actcctggat gaataccggg attatattcg tcaacgcatc gccgatgctc 300
atccttacaa aatcccggca acggtaatcg ctcgcgagat cagagaccag ggatatcgtg 360
gcggaatgac cattctcagg gcattcattc gttctctctc ggttcctcag gagcaggagc 420
ctgccgttcg gttcgaaact gaacccggac gacagatgca ggttgactgg ggcactatgc 480
gtaatggtcg ctcaccgctt cacgtgttcg ttgctgttct cggatacagc cgaatgctgt 540
acatcgaatt cactgacaat atgcgttatg acacgctgga gacctgccat cgtaatgcgt 600
tccgcttctt tggtggtgtg ccgcgcgaag tgttgtatga caatatgaaa actgtggttc 660
tgcaacgtga cgcatatcag accggtcagc accggttcca tccttcgctg tggcagttcg 720
gcaaggagat gggcttctct ccccgactgt gtcgcccctt cagggcacag actaaaggta 780
aggtggaacg gatggtgcag tacacccgta acagttttta catcccacta atgactcgcc 840
tgcgcccgat ggggatcact gtcgatgttg aaacagccaa ccgccacggt ctgcgctggc 900
tgcacgatgt cgctaaccaa cgaaagcatg aaacaatcca ggcccgtccc tgcgatcgct 960
ggctcgaaga gcagcagtcc atgctggcac tgcctccgga gaaaaaagag tatgacgtgc 1020
atcttgatga aaatctggtg aacttcgaca aacaccccct gcatcatcca ctctccatct 1080
acgactcatt ctgcagagga gtggcgtgat gatggaactg caacatcaac gactgatggc 1140
gctcgccggg cagttgcaac tggaaagcct tataagcgca gcgcctgcgc tgtcacaaca 1200
ggcagtagac caggaatgga gttatatgga cttcctggag catctgcttc atgaagaaaa 1260
actggcacgt catcaacgta aacaggcgat gtatacccga atggcagcct tcccggcggt 1320
gaaaacgttc gaagagtatg acttcacatt cgccaccgga gcaccgcaga agcaactcca 1380
gtcgttacgc tcactcagct tcatagaacg taatgaaaat atcgtattac tggggccatc 1440
aggtgtgggg aaaacccatc tggcaatagc gatgggctat gaagcagtcc gtgcaggtat 1500
caaagttcgc ttcacaacag cagcagatct gttacttcag ttatctacgg cacaacgtca 1560
gggccgttat aaaacgacgc ttcagcgtgg agtaatggcc ccccgcctgc tcatcattga 1620
tgaaataggc tatctgccgt tcagtcagga agaagcaaag ctgttcttcc aggtcatcgc 1680
taaacgttac gaaaagagcg caatgatcct gacatccaat ctgccgttcg ggcagtggga 1740
tcaaacgttc gccggtgatg cagcactgac ctcagcgatg ctggaccgta tcttacacca 1800
ctcacatgtc gttcaaatca aaggagaaag ctatcgactc agacagaaac gaaaggccgg 1860
ggttatagca gaagctaatc ctgagtaaaa cggtggatca atattgggcc gttggtggag 1920
atataagtgg atcacttttc atccgtcgtt gacaccctga tgaattcacg tgttcacgcc 1980
tgaataacaa gaatgccgga gatacgcagt catatttttt acacaattct ctaatcccga 2040
caaggtcgta ggtcgttata ggaaaattct tagcaccatt ccggaacaat cagaacagca 2100
ggccatgaac gactgacaac attacgaata taaaaaacgc acccgggcca gacattcccc 2160
ctactgatta aaccagccgg acttgtccac ggaacggtct ttttaaaccg acacacagtc 2220
tgagtacaga tacatgtcac gatgatgcag gattagcgga agagtgtgag cacgtttccg 2280
ggaactgtgg tgaaccatag ctcaatattc gagtgagggc ataccggaaa cgcgctcaga 2340
ttcgttgtaa cgcgattttc cgtaccgggc aattttttca gttgtttttt cgtttcatgt 2400
cgtcagaaac gttctgagcg cgtttccggc atctgatgct acgcaaacca tccccatggt 2460
cagttgacag ccggaaacac gcgggtgtcg ttttagcgta tcgacgggac ggcgtcgaga 2520
agcacaaaaa acagatgttg tactcagtca gttgttttac agacagcact gcggcagatt 2580
gaaaaagtac cgtactttca ggaatgtcca gaaaccatgt gtcagacttc gttctccccc 2640
ttccgggtga atttttttgt catccgttca ggaatctctt tataacgatt actccatttc 2700
aggatttttt atgtggcgtt tactacaggc aggatattca aaggcaaaaa aatcccccgg 2760
aacaggcgga acccggacag ggggagaacg aatcgctaaa taattttcgt agttgtattt 2820
cccatcgttg ctactgcaac gggatgaatt tgccgcagtt tatcctgtaa aacaatcctg 2880
atttactcac actccacata tcactgacgg agcacaacgg aatagtgaac aaacaacaac 2940
aaactgcgct gaatatggcg cgatttatca gaagccagag cctgatactg cttgaaaaac 3000
tggatgctct ggatgccgac gagcaggcgg ccatgtgtga acgactgcac gaactcgcgg 3060
aagaactcca gaacagcatc caggctcgct ttgaagccga aagtgaaaca ggaacataac 3120
gaagctcccg gagacggtca cagcttgtct gtgaacggat gccgggagca gacaagcccg 3180
tcagggcgcg tcagcgggtt ttagcgggtg tcggggcgca gccatgaccc agtcacgtag 3240
cgatagcgga gtgtatactg gcttagtcat gcggcatcag tgcggattgt atgaaaagtg 3300
caccatgtac ggtgtgaaat gccgcacaga tgcgtaagga gaacatgcag atgccgatgc 3360
tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg gcgagcggtg 3420
tctgctcact caaaagcggt gatactgtta tccacacaat caggggataa cgccggaaag 3480
aacatgtgag caaaaaacga agaccccaga aaaggccgcg ccggaggcgc tttttccata 3540
ggctccgccc ccctgacgag catcacaaaa atcgacgctc aagtcagagg tggcgaaacc 3600
cgacaggact taaagatacc aggcgtttcc ccccggaagc tccctcgtgc gctctcctgt 3660
tccgaccctg ccgcttaccg gatacctctc cgcctttctc ccttcgggaa gcgtggcgct 3720
ttctcatagc tcacgctgtt ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg 3780
ctgtgtgcac gaaccccccg ttcagcccga ccactgcgcc ttatccggta actatcgtct 3840
tgagtccaac ccggtaagac acgactttac gccactggca gcagccattg gtaactgaaa 3900
agtggattta gatacgcaga actcttgaag ttgaagcctt atcgcggcta cactgaaagg 3960
acagcatttg gtatctgtgc tccacttaag ccagctacca caggttagaa agcctgagaa 4020
acttctaacc ttcgaaagaa cccacgcctg agaacgtggg ttttttcgtt tacaggcagc 4080
agattacgcg cagaaaaaaa ggatctcaag aagatccttt gatcttttct actgaattgc 4140
gctcccgatc agttcagcag aagattatga tggggttcta tgggtattgc tgcggtaaca 4200
cccatgttac ttgaggttgt atgtagtctg tgtagaatta tacacataag gcttaaactg 4260
ctcttttttt tcaatatgca attggaagtt cattgactac ataaatagat tattccaaat 4320
aatttattta tgtaagaaca ggatgggagg gggaatgatc tcaaagttat tttgcttggc 4380
tctcatattt ttatcatcaa gtggccttgc agaaaaaaac acatatacag caaaagacat 4440
cttgcaaaac ctagaattaa atacctttgg caattcattg tctcatggca tctatgggaa 4500
acagacaacc ttcaagcaaa ccgagtttac aaatattaaa agcaacacca aaaaacacat 4560
tgcacttatc aataaagaca actcatggat gatatcatta aaaatactag gaattaagag 4620
agatgagtat actgtctgtt ttgaagattt ctctctaata agaccgccaa catatgtagc 4680
catacatcct ctacttataa aaaaagtaaa atctggaaac tttatagtag tgaaagaaat 4740
aaagaaatct atccctggtt gcactgtata ttatcattaa tagcaagccc ctcattatta 4800
tgaggggctc atggttattt taacaatcca ctatcgatat ctttttgcac cagagcgccc 4860
tctcgtttac gtctgtcaga cattccatca acaatattat taaaagcatt tacaaggcca 4920
ttccagtctt ttgcgataac tttattccat actgtgggag cagttctgga taacttaaac 4980
cctttttgat atccaataga caccagtgct gtacgggttc tcaacggtaa atcgctgaac 5040
cgaagaccga tattagcgtc attgaaaaga ccttcaatct tatgtgagaa tttatcaata 5100
taaatattag ataagagatg agcttcatta tcagaaagcg tcagaggtgc tgttctcact 5160
ttatcataag cctccttccc tcgaagcata taatacccat caagtctatc tgcaatatac 5220
tgagggacac cgtcattcaa taaatcctgt ttgcttcgct gaccaaggtc aaccccggaa 5280
ccgaatgtaa caccggtact gttaaaataa tcgctactag gattagacgg aaaatgactt 5340
gtcggattaa acccttcaaa accattactg gagaaaatat cgtggtcaac aatatttacc 5400
gaacgacgta aaaattcctt cagttgacta atattgtcaa agttaatgac agtgttgtcc 5460
gctaggacga tgcgatttcg gttattattc agaatgtctt cgttctcttt cttatcgaga 5520
tgttcaatag attcggcaat cgttccctca agaaccatga cacggtagac tttcacaccg 5580
tctttttcct gacctgtttc aacagttatt ttctgttcgt aagacacggt cccttcagtt 5640
tttgaaattt tactttcctg gcggatctta tttgaatatt cactgtcttt ctccatctcc 5700
gtatcaatcg gaaaccccat aatgtacatc agtttaaaat tactccggcc aggcagatcc 5760
acataatgtg gtaatgcaat tgtaatcgaa ttagcttcaa aatttggtct gtaactgctt 5820
aatgtacttc cggaaaagag aaaagccgga acaccacctg aaccattcac taccattgta 5880
tctgacataa aaattcctct ttaacacata aaaaaaacaa taagttaaaa aaatactgta 5940
cataaaagca ctgtttttat gtacagtaat aaaattacgc cgctttattt tctctgtcaa 6000
taatatgaaa tttcattttt gtgatctgaa tcactcttat aaaaatcagg aagggaagat 6060
tcgcagcaga aaaacagcac cgggtaacat cagaaaaaaa cagaaaggag ataacgtgag 6120
caaaacaaaa tctggtcgcc accgactgag caaaacagac aaacgcctgc tggctgcact 6180
tgtcgttgcc ggatacgaag aacggacagc ccgtgacctc atccagaaac acgtttacac 6240
actgacacag gccgacctgc gccatctggt cagtgaaatc agtaacggtg tgggacagtc 6300
acaggcctac gatgcgattt accaggcgag acgcattcgt ctcgcccgta aatacctgag 6360
cggaaaaaaa ccggaagggg tggaaccccg ggaagggcag gaacgggaag atttaccata 6420
actcccgtta tcagtaccat cggctcaacg ctcgttgtcg gatctgaaaa attcgctcaa 6480
aagatcatat ttccctggat attttccacc gtttcttatg tgagaaaagt cacataattc 6540
tgtcagacga cgagaaaacg gatatcgatt attgtttaat atttttacat tattaaaaat 6600
gaaattagat aatcagatac aaataatatg ttttcgttca tgcagagaga ttaagggtgt 6660
ctaatgaaga aaagttctat tgtggcaacc attataacta ttctgtccgg gagtgctaat 6720
gcagcatcat ctcagttaat accaaatata tcccctgaca gctttacagt tgcagcctcc 6780
accgggatgc tgagtggaaa gtctcatgaa atgctttatg acgcagaaac aggaagaaag 6840
atcagccagt tagactggaa gatcaaaaat gtcgctatcc tgaaaggtga tatatcctgg 6900
gatccatact catttctgac cctgaatgcc agggggtgga cgtctctggc ttccgggtca 6960
ggtaatatgg atgactacga ctggatgaat gaaaatcaat ctgagtggac agatcactca 7020
tctcatcctg ctacaaatgt taatcatgcc aatgaatatg acctcaatgt gaaaggctgg 7080
ttactccagg atgagaatta taaagcaggt ataacagcag gatatcagga aacacgtttc 7140
agttggacag ctacaggtgg ttcatatagt tataataatg gagcttatac cggaaacttc 7200
ccgaaaggag tgcgggtaat aggttataac cagcgctttt ctatgccata tattggactt 7260
gcaggccagt atcgcattaa tgattttgag ttaaatgcat tatttaaatt cagcgactgg 7320
gttcgggcac atgataatga tgagcactat atgagagatc ttactttccg tgagaagaca 7380
tccggctcac gttattatgg taccgtaatt aacgctggat attatgtcac acctaatgcc 7440
aaagtctttg cggaatttac atacagtaaa tatgatgagg gcaaaggagg tactcagatc 7500
attgataaga atagtggaga ttctgtctct attggcggag atgctgccgg tatttccaat 7560
aaaaattata ctgtgacggc gggtctgcaa tatcgcttct gaaaaataca gatcatatct 7620
ctcttttcat cctcccctag cggggaggat gtctgtggaa aggaggttgg tgtttgacca 7680
accttcagat gtgtgaaaaa tcaccttttt caccataatg acggggcgct cattctgttg 7740
ttttgccttg acattctcca cgtctttcag ggcatggaga aggtcaaatt agacatggaa 7800
cgctactctc cttcctgtag gaagctcaac atccaagctt aatttgcctc ccattgcttc 7860
aacgtaacgc tttaacgtcg ccagctttaa atcatttccg cgctgctcca gctttgttac 7920
tgctggctgg cttataccca tcgcctcagc aacttgtttt tgtgataact ggagttcttc 7980
acgcatcatc tgcaagccga cctcaagaat catctcatct gccatttctt taattcgtgt 8040
ctggctttca ggtgaacgac tggcaatcac ctcatctaat gttctcatta cttgctctcc 8100
agtgtgttca gatgtgctgt aaattcatcc tcagctatac gcaccagttt ttcataaaac 8160
cgcttatcat tacttttatc tcctgcacaa agaacgatag cccgacgaat cggatcgaac 8220
gcataaaagg ctcttatcgg acggccagaa aactgaacgc gaagctcttt catatttttg 8280
taccgagaac ctttcacggt atcggcatat ggcctgggta actcaggtcc gtaaacctgt 8340
agctttttca aatcagccaa aaccttttcc tgaagagcgt cttcttgctc atttagccag 8400
tcgtcaaatc gctggctaaa aagtaccatc cacatgctca accctataac ctgtagctta 8460
ccccactaac aatataacct acgagttata ttttcaagaa aagctggcta tttaacataa 8520
cggcaatttg tacgcaccac tgaaatgcgt tcagcgcgat cacggcaaca gacaggcaaa 8580
aatagcaaca aacctcccga aaaaccgccg cgatcgcgcc tgataaattt taaccttatg 8640
catatctatg cagccaggcg aatcacgaac gaattgcctg cctgatgtaa ctgaaacggg 8700
tgttttttcc tgatttggtg ggcgtggaag acggaacatg aacgggaaaa cagaattcat 8760
gccagatgag cgcgatctgg caattaaggc aaaacacagc aacaaagaca cgccagaatc 8820
gcgcccggat atgttttaac gcgattttca gactcagaca aattcagcag aatgctactc 8880
cattcaccgg gctgatggtg aatacatgcg tatccaggat gagtacattt ctggctctgc 8940
cacagctctg tctgttggca gctttcgcct gtccggaaac ctgcttaaaa cgctcccgaa 9000
aggcctctga accagaaagc aacaaaacac aggccattaa gtaaatcgcg ttaaaacacg 9060
tctgatggat tgctgcaaaa aaaagtccct aatggagcag ggactgttaa acccagtgaa 9120
tagcgtctaa attaaagtaa gaatacgacc aggtactctt cagaaaagag attaatccac 9180
cgcacagaat aatcaacagt aaaaacaaac aaccctgatt ttttattttt ctttttttcg 9240
ataaaaacaa aattaaagaa ataattaatc agaacattcc ttaacttcag ggcattgcct 9300
gtgttccatt ttgtgattag tctgaaactt ccgaaggtgg ataacacccg gtattttttt 9360
gctcacataa agcccctcct tcaggcagag gggctttttc tttgccacca cataaaaaag 9420
gccctcacag gaggtgttct gtgagggcgt atgataagga ctgaatcgat ggttaatatg 9480
tctagtcctg acttttgcat ctccgaatat aaaaccctgt ttaacggcat gcaaaaccaa 9540
aaaataaaaa tgtgacatcg caatgccaga taatattgac gcatgaggga atgcgtaccc 9600
cgacccctg 9609
//