This repository contains code used to fit history adjusted marginal structural Cox models with a time-to-event outcome. We use this model to estimate the risks to cardiovascular and thromboembolic events (CTE) caused by exposure to fine particulate matter (PM2.5) and either corticosteroids (Steroids
) or Anticoagulants (Anticoagulants
) among high-risk older adults enrolled in Medicare.
Detailed descriptions of the various scripts are available within their respective folders. The R files in the root directory contain the necessary functions for constructing the inverse probability weights and for evaluating additive interactions with either a Cox proportional hazards model or an Aalen additive hazards model.
interaction.R
Functions for evaluating additive and multiplicative interactions.
ipw_fun.R
Functions for generating inverse probability weights (with Random Forest, XGBoost, or GEE).