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DESCRIPTION
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DESCRIPTION
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Package: grantham
Type: Package
Title: Calculate the 'Grantham' Distance
Version: 0.1.1
Authors@R: c(
person(given = "Ramiro", family = "Magno",
email = "ramiro.magno@gmail.com",
role = c("aut", "cre"),
comment = c(ORCID = "0000-0001-5226-3441")),
person(given = "Isabel", family = "Duarte",
email = "iduarte.scientist@gmail.com",
role = "aut",
comment = c(ORCID = "0000-0003-0060-2936")),
person(given = "Ana-Teresa", family = "Maia",
email = "maia.anateresa@gmail.com", role = "aut",
comment = c(ORCID = "0000-0002-0454-9207")),
person("CINTESIS",
role = c("cph", "fnd"))
)
Description: A minimal set of routines to calculate the 'Grantham' distance
<doi:10.1126/science.185.4154.862>. The 'Grantham' distance attempts to
provide a proxy for the evolutionary distance between two amino acids
based on three key chemical properties: composition, polarity and
molecular volume. In turn, evolutionary distance is used as a proxy for
the impact of missense mutations. The higher the distance, the more
deleterious the substitution is expected to be.
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
RoxygenNote: 7.1.2
Depends:
R (>= 2.10)
Imports:
tibble,
magrittr,
vctrs,
dplyr,
tidyr,
rlang,
stringr
URL: https://maialab.org/grantham/, https://github.com/maialab/grantham
BugReports: https://github.com/maialab/grantham/issues
Suggests:
spelling
Language: en-US