If I want to use sklearn, these posts might be useful so as to reproduce the TMVA stuff!
- https://betatim.github.io/posts/sklearn-for-TMVA-users/
- https://betatim.github.io/posts/advanced-sklearn-for-TMVA/
Running on Google Cloud Engine like a cluster.
- https://cloud.google.com/solutions/using-clusters-for-large-scale-technical-computing
- https://cloudplatform.googleblog.com/2018/03/easy-HPC-clusters-on-GCP-with-Slurm.html
It looks like Fermilab has done some of this already with HEPCloud
Try setting up Condor?