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</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s156" id="s38" name="TRE-rtTR_UAS-GV16 (effector)" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>TRE-rtTR_UAS-GV16 (effector)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s159" id="s16" name="lost" compartment="default" initialAmount="0" hasOnlySubstanceUnits="true" boundaryCondition="true" charge="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>DEGRADED</celldesigner:class>
<celldesigner:name>lost</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="CDMT00196" id="s31" name="UAS-Gal4 (amplifier)" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>UAS-Gal4 (amplifier)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re18"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s33" id="s33" name="UAS-GV16 (amplifier)" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>UAS-GV16 (amplifier)</celldesigner:name>
</celldesigner:speciesIdentity>
<celldesigner:listOfCatalyzedReactions>
<celldesigner:catalyzed reaction="re14"/>
</celldesigner:listOfCatalyzedReactions>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s35" id="s35" name="TRE-rtTR_UAS-Gal4 (amplifier)" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
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<celldesigner:name>TRE-rtTR_UAS-Gal4 (amplifier)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s41" id="s41" name="TRE-rtTR (amplifier)" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>TRE-rtTR (amplifier)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
<species metaid="s37" id="s37" name="TRE-rtTR_UAS-GV16 (amplifier)" compartment="default" initialAmount="0">
<annotation>
<celldesigner:extension>
<celldesigner:positionToCompartment>inside</celldesigner:positionToCompartment>
<celldesigner:speciesIdentity>
<celldesigner:class>COMPLEX</celldesigner:class>
<celldesigner:name>TRE-rtTR_UAS-GV16 (amplifier)</celldesigner:name>
</celldesigner:speciesIdentity>
</celldesigner:extension>
</annotation>
</species>
</listOfSpecies>
<listOfParameters>
<parameter metaid="kGV16" id="ka_GV16" name="ka_GV16" value="1.66e-006" units="per_num_per_sec">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>M^-1 min^-1
 (1 10E6 M^-1 s^-1)
http://www.pnas.org/content/106/46/19328.long
</body>
</html>
</notes>
</parameter>
<parameter metaid="k_GV16" id="kd_GV16" name="kd_GV16" value="0.01" units="per_sec">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>s^-1
http://www.pnas.org/content/106/46/19328.long
</body>
</html>
</notes>
</parameter>
<parameter metaid="kl" id="k_l" name="k_l" value="0.00125" units="per_sec">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>Estimated 4000*0,025
http://www.nature.com/nature/journal/v457/n7227/extref/nature07616-s1.pdf
http://2012.igem.org/Team:Slovenia/ModelingPositiveFeedbackLoopSwitch
http://kirschner.med.harvard.edu/files/bionumbers/Comparison%20of%20Pol%20II%20elongation%20rate%20estimates%20derived%20from%20different%20studies2.pdf
</body>
</html>
</notes>
</parameter>
<parameter metaid="kd_p" id="k_deg" name="k_deg" value="2.79045e-005" units="per_sec">
<notes>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<title/>
</head>
<body>min^-1
estimated: t1/2=28h
http://www.ncbi.nlm.nih.gov/pubmed/15456905?dopt=Abstract
</body>
</html>
</notes>
</parameter>
<parameter metaid="ka_NFkB" id="ka_NFkB" name="ka_NFkB" value="1.66e-006" units="per_num_per_sec"/>
<parameter metaid="kd_NFkB" id="kd_NFkB" name="kd_NFkB" value="0.01" units="per_sec"/>
<parameter metaid="k_s_p" id="k_s" name="k_s" value="0.25" units="per_sec"/>
<parameter metaid="k_dil" id="k_dil" name="k_dil" value="8.02254e-006" units="per_sec"/>
<parameter metaid="k_dox" id="k_dox" name="k_dox" value="1.66e-006" units="per_num_per_sec"/>
<parameter metaid="ka_rtTR" id="ka_rtTR" name="ka_rtTR" value="1.66e-006" units="per_num_per_sec"/>
<parameter metaid="kd_rtTR" id="kd_rtTR" name="kd_rtTR" value="0.01" units="per_sec"/>
<parameter metaid="k_deg_luc" id="k_deg_luc" name="k_deg_luc" value="9.62704e-005" units="per_sec"/>
<parameter metaid="k_deg_gal4" id="k_deg_gal4" name="k_deg_gal4" value="0.000115525" units="per_sec"/>
<parameter metaid="k_deg_gv16" id="k_deg_gv16" name="k_deg_gv16" value="0.000154033" units="per_sec"/>
</listOfParameters>
<listOfReactions>
<reaction metaid="re19" id="re1" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
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</celldesigner:baseReactant>
<celldesigner:baseReactant species="s1" alias="sa6">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s43" alias="csa5">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square">
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</annotation>
<listOfReactants>
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<annotation>
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<annotation>
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<kineticLaw metaid="CDMT00020">
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<minus/>
<apply>
<times/>
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<ci> ka_NFkB </ci>
</apply>
<apply>
<times/>
<ci> s43 </ci>
<ci> kd_NFkB </ci>
</apply>
</apply>
</math>
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<annotation>
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<annotation>
<celldesigner:extension>
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<celldesigner:alias>sa2</celldesigner:alias>
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<kineticLaw metaid="CDMT00018">
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<times/>
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<ci> k_s </ci>
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<reaction metaid="re29" id="re3" reversible="false" fast="false">
<annotation>
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</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00103" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa38</celldesigner:alias>
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</annotation>
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<listOfProducts>
<speciesReference metaid="CDMT00104" species="s8">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa15</celldesigner:alias>
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</annotation>
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<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00105" species="s15">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa13</celldesigner:alias>
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<kineticLaw metaid="CDMT00023">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s15 </ci>
<ci> k_s </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re30" id="re4" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
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</celldesigner:baseProduct>
</celldesigner:baseProducts>
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<kineticLaw metaid="CDMT00009">
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<minus/>
<apply>
<times/>
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<ci> s19 </ci>
<ci> ka_GV16 </ci>
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<apply>
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<ci> s33 </ci>
<ci> kd_GV16 </ci>
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</math>
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<times/>
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<kineticLaw metaid="CDMT00046">
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<apply>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s30" alias="sa50">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s57" alias="sa48">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s34" aliases="csa7" targetLineIndex="-1,3">
<celldesigner:connectScheme connectPolicy="direct">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s34" alias="csa7">
<celldesigner:linkAnchor position="ENE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00050" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa50</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00051" species="s57">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00028" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00057">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s34 </ci>
<ci> k_s </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re36" id="re8" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s54" alias="sa2">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s30" alias="sa51">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00053" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00054" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa51</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00055">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s54 </ci>
<ci> k_deg_gv16 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re42" id="re9" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s30" alias="sa62">
<celldesigner:linkAnchor position="SSE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s49" alias="sa63">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s29" aliases="sa59" targetLineIndex="-1,5" editPoints="0.04283583729886287,0.2024868596767912">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s29" alias="sa59">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00077" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa62</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00078" species="s49">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00035" species="s29">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa59</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00080">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s29 </ci>
<ci> k_s </ci>
<cn> 0.01 </cn>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re43" id="re10" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s49" alias="sa63">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s19" alias="sa39">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s31" alias="csa8">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="vertical"/>
<celldesigner:lineDirection arm="0" index="1" value="horizontal"/>
<celldesigner:lineDirection arm="1" index="0" value="horizontal"/>
<celldesigner:lineDirection arm="1" index="1" value="vertical"/>
<celldesigner:lineDirection arm="2" index="0" value="horizontal"/>
<celldesigner:lineDirection arm="2" index="1" value="vertical"/>
<celldesigner:lineDirection arm="2" index="2" value="horizontal"/>
<celldesigner:lineDirection arm="2" index="3" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="1" num1="1" num2="3" tShapeIndex="0">0.9612520971400276,0.19299353067895075 0.9479459475863612,-0.2221360574984549 4.099506044802689,-1.07652277518131 4.007102898889382,-1.428403166347747 0.8430874807979425,-0.5975385154909567 -0.3799249251984682,1.2128749185542087</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00081" species="s49">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00082" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00083" species="s31">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa8</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00084">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> s49 </ci>
<ci> s19 </ci>
<ci> ka_GV16 </ci>
</apply>
<apply>
<times/>
<ci> s31 </ci>
<ci> kd_GV16 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re44" id="re11" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s49" alias="sa63">
<celldesigner:linkAnchor position="ESE"/>
</celldesigner:baseReactant>
<celldesigner:baseReactant species="s28" alias="sa44">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s32" alias="csa9">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection arm="0" index="0" value="horizontal"/>
<celldesigner:lineDirection arm="0" index="1" value="vertical"/>
<celldesigner:lineDirection arm="0" index="2" value="horizontal"/>
<celldesigner:lineDirection arm="1" index="0" value="horizontal"/>
<celldesigner:lineDirection arm="1" index="1" value="vertical"/>
<celldesigner:lineDirection arm="2" index="0" value="vertical"/>
<celldesigner:lineDirection arm="2" index="1" value="horizontal"/>
<celldesigner:lineDirection arm="2" index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints num0="2" num1="1" num2="2" tShapeIndex="0">0.4298975509440526,-0.4213434670222069 0.9198496091460253,0.07855556164820648 0.1649484536082484,-0.3711340206185576 0.02246860773147663,-0.0011800880217069931 0.02521954139797189,0.05119706377617117 0.5080130654390236,-0.15451093135518945</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00085" species="s49">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
<speciesReference metaid="CDMT00086" species="s28">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa44</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00087" species="s32">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa9</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00088">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> s49 </ci>
<ci> s28 </ci>
<ci> ka_GV16 </ci>
</apply>
<apply>
<times/>
<ci> s32 </ci>
<ci> kd_GV16 </ci>
</apply>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re46" id="re12" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s49" alias="sa63">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s30" alias="sa69">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00092" species="s49">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa63</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00093" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa69</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00094">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s49 </ci>
<ci> k_deg_gal4 </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re50" id="re13" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s30" alias="sa87">
<celldesigner:linkAnchor position="E"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s54" alias="sa2">
<celldesigner:linkAnchor position="NW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s1" aliases="sa6" targetLineIndex="-1,3" editPoints="0.03619778639445537,-0.1359361800435852 0.9699850055529393,0.11271749174661672">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
<celldesigner:lineDirection index="2" value="vertical"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s1" alias="sa6">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00010" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa87</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00011" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00012" species="s1">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00047">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s1 </ci>
<ci> k_l </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re51" id="re14" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s30" alias="sa88">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s54" alias="sa2">
<celldesigner:linkAnchor position="SE"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s33" aliases="csa6" targetLineIndex="-1,2" editPoints="0.12149968661689431,0.2239816592984898 0.8941443270109521,-0.19514230811973698">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="horizontal"/>
<celldesigner:lineDirection index="1" value="vertical"/>
<celldesigner:lineDirection index="2" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s33" alias="csa6">
<celldesigner:linkAnchor position="E"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00013" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa88</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00014" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00017" species="s33">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa6</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00048">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s33 </ci>
<ci> k_s </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re52" id="re15" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s30" alias="sa89">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s54" alias="sa2">
<celldesigner:linkAnchor position="SW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
<celldesigner:listOfModification>
<celldesigner:modification type="TRIGGER" modifiers="s19" aliases="sa39" targetLineIndex="-1,2" editPoints="0.26861272688133087,-0.44323800585995143">
<celldesigner:connectScheme connectPolicy="square">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:linkTarget species="s19" alias="sa39">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:linkTarget>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:modification>
</celldesigner:listOfModification>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00024" species="s30">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa89</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00025" species="s54">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa2</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<listOfModifiers>
<modifierSpeciesReference metaid="CDMT00026" species="s19">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa39</celldesigner:alias>
</celldesigner:extension>
</annotation>
</modifierSpeciesReference>
</listOfModifiers>
<kineticLaw metaid="CDMT00049">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s19 </ci>
<ci> k_l </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re53" id="re16" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s30" alias="sa90">
<celldesigner:linkAnchor position="N"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s57" alias="sa48">
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</annotation>
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<annotation>
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</annotation>
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<annotation>
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<kineticLaw metaid="CDMT00052">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
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</apply>
</math>
</kineticLaw>
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</annotation>
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<apply>
<times/>
<ci> s57 </ci>
<ci> k_deg_luc </ci>
</apply>
</math>
</kineticLaw>
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<annotation>
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<apply>
<times/>
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</apply>
</math>
</kineticLaw>
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<annotation>
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<kineticLaw metaid="CDMT00065">
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<apply>
<times/>
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<ci> k_l </ci>
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</math>
</kineticLaw>
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<times/>
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<ci> k_dil </ci>
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</math>
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<apply>
<times/>
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<ci> k_dil </ci>
</apply>
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<times/>
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</apply>
</math>
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<times/>
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<ci> k_dil </ci>
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</math>
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<times/>
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<ci> k_dil </ci>
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</math>
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<times/>
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</math>
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<apply>
<minus/>
<apply>
<times/>
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<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s38 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
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<annotation>
<celldesigner:extension>
<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<apply>
<minus/>
<apply>
<times/>
<ci> s11 </ci>
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<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s42 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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<kineticLaw metaid="CDMT00099">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> s11 </ci>
<ci> s32 </ci>
<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s36 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<celldesigner:reactionType>HETERODIMER_ASSOCIATION</celldesigner:reactionType>
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</celldesigner:baseReactants>
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<celldesigner:extension>
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<kineticLaw metaid="CDMT00111">
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<apply>
<minus/>
<apply>
<times/>
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<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s37 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
</kineticLaw>
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</celldesigner:baseReactants>
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<celldesigner:extension>
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<kineticLaw metaid="CDMT00120">
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<apply>
<minus/>
<apply>
<times/>
<ci> s11 </ci>
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<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s41 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<celldesigner:extension>
<celldesigner:alias>sa117</celldesigner:alias>
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</annotation>
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<celldesigner:extension>
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</annotation>
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<kineticLaw metaid="CDMT00124">
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<apply>
<minus/>
<apply>
<times/>
<ci> s11 </ci>
<ci> s31 </ci>
<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s35 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<celldesigner:extension>
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<minus/>
<apply>
<times/>
<ci> s11 </ci>
<ci> s1 </ci>
<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s40 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
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<celldesigner:alias>sa117</celldesigner:alias>
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<celldesigner:alias>csa17</celldesigner:alias>
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</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00132">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> s11 </ci>
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<ci> ka_rtTR </ci>
</apply>
<apply>
<times/>
<ci> s39 </ci>
<ci> kd_rtTR </ci>
</apply>
</apply>
</math>
</kineticLaw>
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<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
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<celldesigner:alias>sa135</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00169">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s32 </ci>
<ci> k_dil </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re88" id="re48" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s34" alias="csa7">
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</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s16" alias="sa136">
<celldesigner:linkAnchor position="S"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00170" species="s34">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa7</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00171" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa136</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00172">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s34 </ci>
<ci> k_dil </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re89" id="re49" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s36" alias="csa14">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s16" alias="sa137">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
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</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00173" species="s36">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa14</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00174" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa137</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00175">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s36 </ci>
<ci> k_dil </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re90" id="re50" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s42" alias="csa12">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s16" alias="sa138">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00176" species="s42">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa12</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00177" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa138</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00178">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s42 </ci>
<ci> k_dil </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re91" id="re51" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s38" alias="csa13">
<celldesigner:linkAnchor position="SSW"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s16" alias="sa139">
<celldesigner:linkAnchor position="NNW"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="direct" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="unknown"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00179" species="s38">
<annotation>
<celldesigner:extension>
<celldesigner:alias>csa13</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00180" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa139</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00181">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s38 </ci>
<ci> k_dil </ci>
</apply>
</math>
</kineticLaw>
</reaction>
<reaction metaid="re92" id="re52" reversible="false" fast="false">
<annotation>
<celldesigner:extension>
<celldesigner:reactionType>STATE_TRANSITION</celldesigner:reactionType>
<celldesigner:baseReactants>
<celldesigner:baseReactant species="s57" alias="sa48">
<celldesigner:linkAnchor position="NNE"/>
</celldesigner:baseReactant>
</celldesigner:baseReactants>
<celldesigner:baseProducts>
<celldesigner:baseProduct species="s16" alias="sa140">
<celldesigner:linkAnchor position="W"/>
</celldesigner:baseProduct>
</celldesigner:baseProducts>
<celldesigner:connectScheme connectPolicy="square" rectangleIndex="0">
<celldesigner:listOfLineDirection>
<celldesigner:lineDirection index="0" value="vertical"/>
<celldesigner:lineDirection index="1" value="horizontal"/>
</celldesigner:listOfLineDirection>
</celldesigner:connectScheme>
<celldesigner:editPoints>0.6989761092150184,-0.45870307167235325</celldesigner:editPoints>
<celldesigner:line width="1.0" color="ff000000"/>
</celldesigner:extension>
</annotation>
<listOfReactants>
<speciesReference metaid="CDMT00182" species="s57">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa48</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfReactants>
<listOfProducts>
<speciesReference metaid="CDMT00183" species="s16">
<annotation>
<celldesigner:extension>
<celldesigner:alias>sa140</celldesigner:alias>
</celldesigner:extension>
</annotation>
</speciesReference>
</listOfProducts>
<kineticLaw metaid="CDMT00184">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> s57 </ci>
<ci> k_dil </ci>
<cn type="integer"> 0 </cn>
</apply>
</math>
</kineticLaw>
</reaction>
</listOfReactions>
</model>
</sbml>